Ghrelin increases cis-platinum resistance and promotes aggressiveness of osteosarcoma by activating AKT and Wnt/β-catenin pathways

Authors: Menglin Cong, Shufeng Li, Yu Fu, Ting Wang, Huizhen Wei, Xiaojie Ma, Fangming Liu, XieHuang Sheng, Kehan Long, Haocheng Hou, Xuecheng Sun, Weiwei Li, Lei Zhang

Source: Journal of Orthopaedic Surgery and Research, Vol 20, Iss 1, Pp 1-12 (2025)

Subject Terms: Ghrelin, Osteosarcoma, Drug-resistence, Wnt/β-catenin pathway, AKT pathway, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1749-799X

Access URL: https://doaj.org/article/006857b0403247f390bdb50a5bfdf2be

MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway

Authors: Yuanyuan Guo, Kai Shen, Zhijie Li, Changchun Niu, Yang Luo

Source: Journal of Orthopaedic Surgery and Research, Vol 20, Iss 1, Pp 1-16 (2025)

Subject Terms: MiR-147b-3p, Type I coenzyme dehydrogenase 1α subcomplex 4 (NDUFA4), Phosphatidylinositol 3-kinase (PI3K)/AKT pathway, Osteogenesis vertebral compression fractures (OVCF), Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1749-799X

Access URL: https://doaj.org/article/be2b5e17d07e4fc5847f667da6869e90

3-bromo-4-(2-hydroxyethyl)-7-methoxy-2H-chromen-2-one inhibits allergic reactions in IgE-mediated RBL-2H3 cells and a passive cutaneous anaphylaxis mouse model

Authors: Moonsu Kim, Huiji Kim, Sun Young Moon, Seong-Ah Shin, Minji Kim, Seyeon Choi, Sugeun Gwon, Jun Hyuck Lee, Hyun Ho Park, Chang Sup Lee

Source: Applied Biological Chemistry, Vol 68, Iss 1, Pp 1-11 (2025)

Subject Terms: Allergy, Mast cells, 3-Bromo-4-(2-Hydroxyethyl)-7-Methoxy-2H-Chromen-2-One, Anti-Allergic therapeutics, AKT pathway, MAPK pathway, Agriculture (General), S1-972, Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2468-0842

Access URL: https://doaj.org/article/6e20f790b0234c2a9164ea227485fce2

The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway

Authors: Jinliang Huan, Xiaojun Liu, Na Wang, Yuxin Mu, Ling Li, Yiqun Du

Source: Biology Direct, Vol 19, Iss 1, Pp 1-15 (2024)

Subject Terms: RRP9, Breast cancer, JUN, AKT pathway, Poor prognosis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6150

Access URL: https://doaj.org/article/e0ed03d92dbd4269ace5ee94e4f7fd71

microRNA-875-5p-conjugated gold nanoparticles suppress breast cancer progression through the MTDH/PTEN/AKT signaling pathway

Authors: Bin Xiong, Junfeng Zhang, Yanmei Si, Jia Fu

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: MiR-875-5p, Gold nanoparticles, MTDH, PTEN/Akt pathway, Breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/9114c1ae2f40491fbdaebf4d1349527f

Endothelial progenitor cell-derived conditioned medium mitigates chronic cerebral ischemic injury through macrophage migration inhibitory factor-activated AKT pathway

Authors: Ya-Wen Cheng, Ling-Yu Yang, Yi-Tzu Chen, Sheng-Che Chou, Kuo-Wei Chen, Yi-Hsing Chen, Chuan-Rou Deng, I-Chin Chen, Wan-Ju Chou, Chen-Chih Chang, Yong-Ren Chen, Hsiao-Lin Hwa, Kuo-Chuan Wang, Meng-Fai Kuo

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Endothelial progenitor cell-derived conditioned medium, Cerebral ischemia, Macrophage migration inhibitory factor, AKT pathway, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/a481a46ec77f4d2280fb782aee0a8fe9

Targeting m7G-enriched circKDM1A prevents colorectal cancer progression

Authors: Zhenqiang Sun, Yanxin Xu, Chaohua Si, Xiaoke Wu, Yaxin Guo, Chen Chen, Chengzeng Wang

Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)

Subject Terms: M7G modification, circRNA, AKT pathway, Colorectal cancer (CRC), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/63421d25c240434598ccac31d9695305

MIR-4421 AS A POSSIBLE MODULATOR OF MAPK/AKT PATHWAY THROUGH ERP29 IN PHARYNGEAL CANCER

Authors: Juliana Carron, Carmen Silvia Passos Lima, Gustavo Jacob Lourenço

Source: Hematology, Transfusion and Cell Therapy, Vol 47, Iss , Pp 103804- (2025)

Subject Terms: ERP29, MAPK/Akt pathway, miR-4421, Pharyngeal cancer, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2531137925000720; https://doaj.org/toc/2531-1379

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Astragaloside IV promotes neuronal axon regeneration by inhibiting the PTEN/AKT pathway

Authors: Lin, Luning ^a, Zhao, Chenyang ^b, Lv, Huijuan ^c, Zhu, Liangrong ^d, Wang, Wangen ^a, Zheng, Xintian ^{a, ⁎, 1}

Source: In Brain Research 1 March 2025 1850

Anticancer and therapeutic efficacy of XPO1 inhibition in pancreatic ductal adenocarcinoma through DNA damage and modulation of miR-193b/KRAS/LAMC2/ERK/AKT signaling cascade

Authors: Kirtonia, Anuradha ^{a, 1, 2}, Pandya, Gouri ^{a, 1, 2}, Singh, Aishwarya ^{a, 1, 2}, Kumari, Rachana ^a, Singh, Bhavana ^a, Kapoor, Sonia ^{a, ⁎}, Khattar, Ekta ^b, Pandey, Amit Kumar ^{c, ⁎⁎}, Garg, Manoj ^{a, ⁎}

Source: In Life Sciences 1 February 2025 362

Role of HDAC3 in the epithelial-mesenchymal transition of retinal pigment epithelium cells: Implications for proliferative vitreoretinopathy

Authors: Weikang Zou, Chunling Huang, Yuting Chen, Jing Tang, Qiqi Li, Qi Fang, Yulin Ma, Wei Wu, Songfu Feng

Source: Heliyon, Vol 10, Iss 21, Pp e39333- (2024)

Subject Terms: Proliferative vitreoretinopathy, Epithelial-mesenchymal transiton, Retinal pigment epithelium, Histone deacetylase 3, MAZ, AKT pathway, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024153649; https://doaj.org/toc/2405-8440

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Automatically Navigating Protein Interaction Networks with a Software Product Line Approach

Authors: Munoz, Daniel-Jesus, Medina-Vera, Dina

Source: 2020 International Conference on Decision Aid Sciences and Application (DASA) Decision Aid Sciences and Application (DASA), 2020 International Conference on. :1155-1159 Nov, 2020

Relation: 2020 International Conference on Decision Aid Sciences and Application (DASA)

CELF2 inhibits bladder cancer progression by decreasing the stability of CXCL5

Authors: Dong, Shiqiang ^{a, b, 1}, Wang, Lili ^{b, c, 1}, Liu, Xinyu ^{a, 1}, Hou, Dingkun ^b, Liu, Qing ^b, Zheng, Ji ^{a, ⁎}, Wang, Haitao ^{b, ⁎}

Source: In Life Sciences 1 June 2025 370

MSTN gene knockout suppresses the activation of lung fibroblasts through the inhibition of the Smad/AKT signaling pathway, thereby ameliorating pulmonary fibrosis

Authors: Quan, Biao-Hu ^{a, b, 1}, Liu, Xin-Yue ^{a, 1}, Li, Zhou-Yan ^{a, 1}, Han, Sheng-Zhong ^a, Cui, Qi-Chao ^a, Chang, Shuang-Yan ^a, Lv, Si-Tong ^a, Yin, Xi-Jun ^{a, ⁎}, Liang, Shuang ^{b, ⁎}

Source: In Cellular Signalling May 2025 129

Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson’s Disease

Authors: Cai B, Wang Q, Zhong L, Liu F, Wang X, Chen T

Source: Drug Design, Development and Therapy, Vol Volume 18, Pp 2869-2881 (2024)

Subject Terms: parkinson’s disease, curcumin, network pharmacology, transcriptomics, pi3k / akt pathway, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/integrating-network-pharmacology-transcriptomics-to-reveal-neuroprotec-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881

Access URL: https://doaj.org/article/2d7295b9c550448b8103541eb9f1fb42

FLNA overexpression promotes papillary thyroid cancer aggression via the FAK/AKT signaling pathway

Authors: Weiwei Liang, Yilin Zhang, Yan Guo, Pengyuan Zhang, Jiewen Jin, Hongyu Guan, Yanbing Li

Source: Endocrine Connections, Vol 13, Iss 6, Pp 1-11 (2024)

Subject Terms: flna, invasion, migration, papillary thyroid cancer, fak/akt pathway, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://ec.bioscientifica.com/view/journals/ec/13/6/EC-24-0034.xml; https://doaj.org/toc/2049-3614

Access URL: https://doaj.org/article/2117a0632a8b4d0094b14eaaf04aea31

Exploring recent advances in signaling pathways and hallmarks of uveal melanoma: a comprehensive review

Authors: Majid Banimohammad, Parsa Khalafi, Danial Gholamin, Zahra Bangaleh, Nahid Akhtar, Abhishikt David Solomon, Pranav Kumar Prabhakar, Samira Sanami, Ajit Prakash, Hamidreza Pazoki-Toroudi

Source: Exploration of Targeted Anti-tumor Therapy, Vol 6, p 1002306 (2025)

Subject Terms: uveal melanoma, rat sarcoma virus (ras) pathway, akt pathway, hippo pathway, retinoblastoma (rb) pathway, p53 pathway, hallmarks of cancer, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://www.explorationpub.com/uploads/Article/A1002306/1002306.pdf; https://doaj.org/toc/2692-3114

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The Tumor-Suppressive Role of miR-204-5p Through Targeting Ezrin in Breast Cancer: Experimental Evidence From Cell Lines and Clinical Samples

Authors: Dong, Tianfu ^{1, 2}, Zhou, Honglei ², Tang, Jinhai ^{2, ⁎}

Source: In Clinical Breast Cancer February 2025

Early-life bisphenol A exposure causes detrimental age-related changes in anxiety, depression, learning, and memory in juvenile and adult male rats: Involvement of NMDAR/PSD-95–PTEN/AKT signaling pathway

Authors: Al-Shami, Ahmed S. ^a, Haroun, Medhat ^a, Essawy, Amina E. ^b, Moussa, Nermine ^a, Abd Elkader, Heba-Tallah Abd Elrahim ^{c, ⁎, 1}

Source: In Neurotoxicology January 2025 106:17-36

The role of ESM1 in the lipids metabolic reprogramming and angiogenesis of lung adenocarcinoma cells

Authors: Wenchang Feng, Yi Ting, Xing Tang, Dan Liu, Wen-chao Zhou, Yukun Li, Zhenyu Shen

Source: Heliyon, Vol 10, Iss 17, Pp e36897- (2024)

Subject Terms: Lung adenocarcinoma, ESM1, AKT pathway, Tumor metabolic reprogramming, Angiogenesis, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024129283; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/c92eb747d724442d8e4193831ec361fa