A Network-Based Framework to Discover Treatment-Response–Predicting Biomarkers for Complex Diseases

Authors: Shanthamallu, Uday S., Kilpatrick, Casey, Jones, Alex, Rubin, Jonathan, Saleh, Alif, Barabási, Albert-László, Akmaev, Viatcheslav R., Ghiassian, Susan D.

Source: In The Journal of Molecular Diagnostics October 2024 26(10):917-930

Network-based response module comprised of gene expression biomarkers predicts response to infliximab at treatment initiation in ulcerative colitis

Authors: Ghiassian, SUSAN D, VOITALOV, IVAN, WITHERS, JOHANNA B, SANTOLINI, MARC, SALEH, ALIF, AKMAEV, VIATCHESLAV R

Source: In Translational Research August 2022 246:78-86

Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis

Authors: Curtis, Jeffrey R., Strand, Vibeke, Golombek, Steven, Zhang, Lixia, Wong, Angus, Zielinski, Mark C., Akmaev, Viatcheslav R., Saleh, Alif, Asgarian, Sam, Withers, Johanna B.

Source: Expert review of molecular diagnostics. 22(10):973-982

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165442519.0x000001&indx=1&recIds=ETOCvdc_100165442519.0x000001

RETRACTED: Network-based response module comprised of gene expression biomarkers predicts response to infliximab at treatment initiation in ulcerative colitis

Authors: Ghiassian, Susan D., Withers, Johanna B., Santolini, Marc, Saleh, Alif, Akmaev, Viatcheslav R.

Source: Translational research. 239:35-43

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158389117.0x000001&indx=1&recIds=ETOCvdc_100158389117.0x000001

Analytical and clinical validation of an RNA sequencing-based assay for quantitative, accurate evaluation of a molecular signature response classifier in rheumatoid arthritis

Authors: Jones, Alex, Rapisardo, Sarah, Zhang, Lixia, Mellors, Theodore, Withers, Johanna B., Gatalica, Zoran, Akmaev, Viatcheslav R.

Source: Expert review of molecular diagnostics. 21(11):1235-1243

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134791775.0x000001&indx=1&recIds=ETOCvdc_100134791775.0x000001

BAIcis: A Novel Bayesian Network Structural Learning Algorithm and Its Comprehensive Performance Evaluation Against Open-Source Software

Authors: Zhang, Lixia, Rodrigues, Leonardo O., Narain, Niven R., Akmaev, Viatcheslav R.

Source: Journal of computational biology. 27(5):698-708

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153561034.0x000001&indx=1&recIds=ETOCvdc_100153561034.0x000001

Human CCDC47 sandwich immunoassay development with electrochemiluminescence technology

Authors: Wu, Wenfang S., Zhu, Liang, Patil, Saurabh, Gokul, Karthiga, Reilly, Sean, Chan, Joyce, Tekumalla, Poornima, Vishnudas, Vivek, Kiebish, Michael A., Sarangarajan, Rangaprasad, Akmaev, Viatcheslav R., Kellogg, Mark D., Narain, Niven R.

Source: In Journal of Immunological Methods January 2018 452:12-19

Non-obvious correlations to disease management unraveled by Bayesian artificial intelligence analyses of CMS data

Authors: Vemulapalli, Vijetha, Qu, Jiaqi, Garren, Jeonifer M., Rodrigues, Leonardo O., Kiebish, Michael A., Sarangarajan, Rangaprasad, Narain, Niven R., Akmaev, Viatcheslav R.

Source: In Artificial Intelligence In Medicine November 2016 74:1-8

Decision Impact Analysis to Measure the Influence of Molecular Signature Response Classifier Testing on Treatment Selection in Rheumatoid Arthritis.

Authors: Curtis, Jeffrey R., Strand, Vibeke, Golombek, Steven J., Karpouzas, George A., Zhang, Lixia, Wong, Angus, Patel, Krishna, Dines, Jennifer, Akmaev, Viatcheslav R.

Source: Rheumatology & Therapy; Feb2024, Vol. 11 Issue 1, p61-77, 17p

Subject Terms: DECISION making, ANTIRHEUMATIC agents, HEALTH insurance, TUMOR necrosis factors, INDIVIDUALIZED medicine, RHEUMATOID arthritis

The human sex ratio from conception to birth

Authors: Orzack, Steven Hecht, Stubblefield, J. William, Akmaev, Viatcheslav R., Colls, Pere, Munné, Santiago, Scholl, Thomas, Steinsaltz, David, Zuckerman, James E.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Apr . 112(16), E2102-E2111.

Access URL: https://www.jstor.org/stable/26462361

S794 Pathway Enrichment Analysis Reveals Ulcerative Colitis Patients With Non-Response to TNFi Therapy May Have More Biological Dysregulation

Authors: Voitalov, Ivan, Ghanjanasak, Tanyatorn, Le-Short, Christina, Withers, Johanna B., Akmaev, Viatcheslav R., Ghiassian, Susan D.

Source: American journal of gastroenterology. 117(10):e565-e566

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194763224.0x000001&indx=1&recIds=ETOCvdc_100194763224.0x000001

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Copy number analysis of genetic locus

Clinical metabolomics: a pivotal tool for companion diagnostic development and precision medicine

Authors: Tolstikov, Vladimir, Akmaev, Viatcheslav R., Sarangarajan, Rangaprasad, Narain, Niven R., Kiebish, Michael A.

Source: Expert review of molecular diagnostics. 17(5):411-413

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106478795.0x000001&indx=1&recIds=ETOCvdc_100106478795.0x000001

Genetic heterozygosity and pseudodeficiency in the Pompe disease newborn screening pilot program

Authors: Labrousse, Paul, Chien, Yin-Hsiu, Pomponio, Robert J., Keutzer, Joan, Lee, Ni-Chung, Akmaev, Viatcheslav R., Scholl, Thomas, Hwu, Wuh-Liang

Source: In Molecular Genetics and Metabolism 2010 99(4):379-383

Retraction notice to 'Network-based response module comprised of gene expression biomarkers predicts response to infliximab at treatment initiation in ulcerative colitis' Translational Research 239C (2021) 35–43

Authors: Akmaev, Viatcheslav R., Ghiassian, Susan D., Withers, Johanna B., Santolini, Marc, Saleh, Alif

Source: Translational research. 244:137-137

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165430815.0x000001&indx=1&recIds=ETOCvdc_100165430815.0x000001

Commentary on Cohen et al.: Role of Clinical Factors in Precision Medicine Test to Predict Nonresponse to TNFi Therapies in Rheumatoid Arthritis.

Authors: Cohen, Stanley, Curtis, Jeffrey R., Mellors, Theodore, Zhang, Lixia, Withers, Johanna B., Jones, Alex, Ghiassian, Susan D., Akmaev, Viatcheslav R.

Source: Rheumatology & Therapy; Feb2023, Vol. 10 Issue 1, p1-6, 6p

Subject Terms: INDIVIDUALIZED medicine, BODY mass index, GENE expression

The module triad: a novel network biology approach to utilize patients' multi-omics data for target discovery in ulcerative colitis.

Authors: Voitalov, Ivan, Zhang, Lixia, Kilpatrick, Casey, Withers, Johanna B., Saleh, Alif, Akmaev, Viatcheslav R., Ghiassian, Susan Dina

Source: Scientific Reports; 12/15/2022, Vol. 12 Issue 1, p1-16, 16p

Subject Terms: ULCERATIVE colitis, SYSTEMS biology, BIOLOGY, GENE regulatory networks, DRUG development, PROTEIN-protein interactions, SOCIAL interaction

GC Wave Correction for Array-Based Comparative Genomic Hybridization

Identification of Differentially Represented Fetal or Maternal Genomic Regions and Uses Thereof