Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin

Authors: Sakata, Juri, Tatsumi, Toshifumi, Sugiyama, Akira, Shimizu, Akihiro, Inagaki, Yuya, Katoh, Hiroto, Yamashita, Takefumi, Takahashi, Kazuki, Aki, Sho, Kaneko, Yudai, Kawamura, Takeshi, Miura, Mai, Ishii, Masazumi, Osawa, Tsuyoshi, Tanaka, Toshiya, Ishikawa, Shumpei, Tsukagoshi, Masanobu, Chansler, Michael, Kodama, Tatsuhiko, Kanai, Motomu, Tokuyama, Hidetoshi, Yamatsugu, Kenzo

Source: In Protein Expression and Purification February 2024 214

Cancer metabolism within tumor microenvironments

Authors: Aki, Sho, Nakahara, Ryuichi, Maeda, Keisuke, Osawa, Tsuyoshi

Source: In BBA - General Subjects May 2023 1867(5)

Antibody mimetic drug conjugate manufactured by high-yield Escherichia coli expression and non-covalent binding system

Authors: Yamatsugu, Kenzo, Katoh, Hiroto, Yamashita, Takefumi, Takahashi, Kazuki, Aki, Sho, Tatsumi, Toshifumi, Kaneko, Yudai, Kawamura, Takeshi, Miura, Mai, Ishii, Masazumi, Ohkubo, Kei, Osawa, Tsuyoshi, Kodama, Tatsuhiko, Ishikawa, Shumpei, Kanai, Motomu, Sugiyama, Akira

Source: In Protein Expression and Purification April 2022 192

Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice

Authors: Islam, Shahidul ¹, Yoshioka, Kazuaki ¹, Aki, Sho ¹, Ishimaru, Kazuhiro ¹, Yamada, Hiroki ¹, Takuwa, Noriko ^{1, 2}, Takuwa, Yoh ¹

Source: In The Journal of Physiological Sciences 2020 70(1)

The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells

Authors: Aung, Khin Thuzar ¹, Yoshioka, Kazuaki ¹, Aki, Sho ¹, Ishimaru, Kazuhiro ¹, Takuwa, Noriko ^{1, 2}, Takuwa, Yoh ^{1, f}

Source: In The Journal of Physiological Sciences March 2019 69(2):263-280

Phosphatidylinositol 3-Kinase Class II α-Isoform PI3K-C2α Is Required for Transforming Growth Factor β-induced Smad Signaling in Endothelial Cells

Authors: Aki, Sho, Yoshioka, Kazuaki, Okamoto, Yasuo, Takuwa, Noriko, Takuwa, Yoh

Source: In Journal of Biological Chemistry 6 March 2015 290(10):6086-6105

Hypoxia activates SREBP2 through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth.

Authors: Nakahara, Ryuichi^1,2 (AUTHOR), Aki, Sho^1,2 (AUTHOR), Sugaya, Maki¹ (AUTHOR), Hirose, Haruka³ (AUTHOR), Kato, Miki¹ (AUTHOR), Maeda, Keisuke¹ (AUTHOR), Sakamoto, Daichi M² (AUTHOR), Kojima, Yasuhiro³ (AUTHOR), Nishida, Miyuki¹ (AUTHOR), Ando, Ritsuko¹ (AUTHOR), Muramatsu, Masashi⁴ (AUTHOR), Pan, Melvin¹ (AUTHOR), Tsuchida, Rika¹ (AUTHOR), Matsumura, Yoshihiro⁵ (AUTHOR), Yanai, Hideyuki⁶ (AUTHOR), Takano, Hiroshi⁷ (AUTHOR), Yao, Ryoji⁷ (AUTHOR), Sando, Shinsuke^2,8 (AUTHOR), Shibuya, Masabumi⁹ (AUTHOR), Sakai, Juro^5,10 (AUTHOR)

Source: EMBO Journal. Nov2023, Vol. 42 Issue 22, p1-22. 22p.

Subject Terms: *TUMOR growth, *MONOCYTES, *MYELOID cells, *HYPOXEMIA, *BONE marrow, *NEOVASCULARIZATION, *CANCER cells

Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma.

Authors: Kitagawa, Akihiro, Osawa, Tsuyoshi, Noda, Miwa, Kobayashi, Yuta, Aki, Sho, Nakano, Yusuke, Saito, Tomoko, Shimizu, Dai, Komatsu, Hisateru, Sugaya, Maki, Takahashi, Junichi, Kosai, Keisuke, Takao, Seiichiro, Motomura, Yushi, Sato, Kuniaki, Hu, Qingjiang, Fujii, Atsushi, Wakiyama, Hiroaki, Tobo, Taro, Uchida, Hiroki

Source: British Journal of Cancer; Jun2023, Vol. 128 Issue 12, p2206-2217, 12p

Metabolic adaptations of cancer in extreme tumor microenvironments.

Authors: Nakahara, Ryuichi, Maeda, Keisuke, Aki, Sho, Osawa, Tsuyoshi

Source: Cancer Science; Apr2023, Vol. 114 Issue 4, p1200-1207, 8p

Pathological complete remission of relapsed tumor by photo‐activating antibody–mimetic drug conjugate treatment.

Authors: Kaneko, Yudai, Yamatsugu, Kenzo, Yamashita, Takefumi, Takahashi, Kazuki, Tanaka, Toshiya, Aki, Sho, Tatsumi, Toshifumi, Kawamura, Takeshi, Miura, Mai, Ishii, Masazumi, Ohkubo, Kei, Osawa, Tsuyoshi, Kodama, Tatsuhiko, Ishikawa, Shumpei, Tsukagoshi, Masanobu, Chansler, Michael, Sugiyama, Akira, Kanai, Motomu, Katoh, Hiroto

Source: Cancer Science; Dec2022, Vol. 113 Issue 12, p4350-4362, 13p

Publisher Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment

Authors: Ikeda, Hideki, Kawase, Katsushige, Nishi, Tatsuya, Watanabe, Tomofumi, Takenaga, Keizo, Inozume, Takashi, Ishino, Takamasa, Aki, Sho, Lin, Jason, Kawashima, Shusuke, Nagasaki, Joji, Ueda, Youki, Suzuki, Shinichiro, Makinoshima, Hideki, Itami, Makiko, Nakamura, Yuki, Tatsumi, Yasutoshi, Suenaga, Yusuke, Morinaga, Takao, Honobe-Tabuchi, Akiko, Ohnuma, Takehiro, Kawamura, Tatsuyoshi, Umeda, Yoshiyasu, Nakamura, Yasuhiro, Kiniwa, Yukiko, Ichihara, Eiki, Hayashi, Hidetoshi, Ikeda, Jun-ichiro, Hanazawa, Toyoyuki, Toyooka, Shinichi, Mano, Hiroyuki, Suzuki, Takuji, Osawa, Tsuyoshi, Kawazu, Masahito, Togashi, Yosuke

Source: Nature; March 2025, Vol. 639 Issue: 8053 pE5-E5, 1p

Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells.

Authors: Shimizu, Shota, Yoshioka, Kazuaki, Aki, Sho, Takuwa, Yoh

Source: Scientific Reports; 3/4/2021, Vol. 11 Issue 1, p1-17, 17p

Subject Terms: PHOSPHATIDYLINOSITOL 3-kinases, NEOVASCULARIZATION, NOTCH signaling pathway, ENDOTHELIAL cells, ENDOCYTOSIS, SECRETASES

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TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K–C2α-, and INPP4B-mediated phosphoinositide conversions

Authors: Aki, Sho, Yoshioka, Kazuaki, Takuwa, Noriko, Takuwa, Yoh

Source: Molecular Biology of the Cell; March 2020, Vol. 31 Issue: 5 p360-372, 13p

Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice.

Authors: Sarker, Md Azadul Kabir, Aki, Sho, Yoshioka, Kazuaki, Kuno, Kouji, Okamoto, Yasuo, Ishimaru, Kazuhiro, Takuwa, Noriko, Takuwa, Yoh

Source: Endocrinology; January 2019, Vol. 160 Issue: 1 p235-248, 14p

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Endothelial PI3K-C2?, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.

Authors: Yoshioka, Kazuaki¹, Yoshida, Kotaro², Cui, Hong³, Wakayama, Tomohiko⁴, Takuwa, Noriko⁵, Okamoto, Yasuo³, Du, Wa³, Qi, Xun³, Asanuma, Ken⁶, Sugihara, Kazushi⁷, Aki, Sho³, Miyazawa, Hidekazu³, Biswas, Kuntal³, Nagakura, Chisa³, Ueno, Masaya⁸, Iseki, Shoichi⁴, Schwartz, Robert J⁹, Okamoto, Hiroshi¹⁰, Sasaki, Takehiko¹¹, Matsui, Osamu¹²

Source: Nature Medicine; Oct2012, Vol. 18 Issue 10, p1560-1569, 10p, 6 Graphs

Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model.

Authors: Okumura, Kenichiro, Yoshida, Kotaro, Yoshioka, Kazuaki, Aki, Sho, Yoneda, Norihide, Inoue, Dai, Kitao, Azusa, Ogi, Takahiro, Kozaka, Kazuto, Minami, Tetsuya, Koda, Wataru, Kobayashi, Satoshi, Takuwa, Yoh, Gabata, Toshifumi

Source: European Radiology Experimental; 12/1/2018, Vol. 2 Issue 1, pN.PAG-N.PAG, 1p

Subject Terms: ACOUSTIC imaging, INDOCYANINE green, HOMOGRAFTS, IMMUNOSTAINING, SALIVARY glands, INTRAVENOUS injections

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