Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10

Authors: Lee, WonJae ¹, Ko, Song Yi ¹, Akasaka, Hironari ¹, Weigert, Melanie ², Lengyel, Ernst ², Naora, Honami ^{1, 3, ∗}

Source: In Cancer Cell 13 January 2025 43(1):69-85

Revisiting the Use of Normal Saline for Peritoneal Washing in Ovarian Cancer.

Authors: Akasaka, Hironari¹ (AUTHOR), Naora, Honami¹ (AUTHOR) hnaora@mdanderson.org

Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 22, p16449. 13p.

Subject Terms: *OMENTUM, *OVARIAN cancer, *PERITONEUM, *ONCOLOGIC surgery, *ASCITIC fluids, *METASTASIS

Engineering 'Enzymelink' for screening lead compounds to inhibit mPGES-1 while maintaining prostacyclin synthase activity

Authors: Ruan, Diana T, Tang, Nanhong, Akasaka, Hironari, Lu, Renzhong, Ruan, Ke-He

Source: Future medicinal chemistry. 13(13):1091-1103

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187428703.0x000001&indx=1&recIds=ETOCvdc_100187428703.0x000001

Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer

Authors: Song, Xianzhou, Akasaka, Hironari, Wang, Hua, Abbasgholizadeh, Reza, Shin, Ji-Hyun, Zang, Fenglin, Chen, Jiayi, Logsdon, Craig D., Maitra, Anirban, Bean, Andrew J. ^**, Wang, Huamin

Source: In Journal of Biological Chemistry 21 February 2020 295(8):2348-2358

The Protective Effects of Up-Regulating Prostacyclin Biosynthesis on Neuron Survival in Hippocampus

Authors: Ling, Qing-Lan, Akasaka, Hironari, Chen, Chang, Haile, Colin N, Winoske, Kevin, Ruan, Ke-He

Source: Journal of neuroimmune pharmacology. 15(2):292-308

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171768830.0x000001&indx=1&recIds=ETOCvdc_100171768830.0x000001

Expression and Clinical Significance of Protein Kinase RNA–Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2α in Pancreatic Ductal Adenocarcinoma

Authors: Wang, Eric M., Akasaka, Hironari, Zhao, Jun, Varadhachary, Gauri R., Lee, Jeffrey E., Maitra, Anirban, Fleming, Jason B., Hung, Mien-Chie, Wang, Huamin, Katz, Matthew H. G.

Source: Pancreas. 48(3):323-328

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100078038014.0x000001&indx=1&recIds=ETOCvdc_100078038014.0x000001

The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2- and retaining PGE1-mediated signaling in live cells

Authors: Akasaka, Hironari, Thaliachery, Natasha, Zheng, Xianghai, Blumenthal, Marissa, Nikhar, Sameer, Murdoch, Emma E., Ling, Qinglan, Ruan, Ke-He

Source: In Archives of Biochemistry and Biophysics 15 February 2017 616:20-29

Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage

Authors: Ling, Qing-Lan, Mohite, Anita, Murdoch, Emma, Akasaka, Hironari, Li, Qun-Ying, So, Shui-Ping, Ruan, Ke-He

Source: Scientific reports. 8(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111635280.0x000001&indx=1&recIds=ETOCvdc_100111635280.0x000001

Identification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1

Authors: Akasaka, Hironari, Ruan, Ke-He

Source: In Archives of Biochemistry and Biophysics 1 August 2016 603:29-37

Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior

Authors: Vollert, Craig, Ohia, Odochi, Akasaka, Hironari, Berridge, Casey, Ruan, Ke-He, Eriksen, Jason L.

Source: In Behavioural Brain Research 1 January 2014 258:138-144

How can we target oxidative stress in the treatment of neurodegenerative diseases?

Authors: Akasaka, Hironari, Ruan, Ke-He

Source: Future medicinal chemistry. 8(8):835-839

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115568842.0x000001&indx=1&recIds=ETOCvdc_100115568842.0x000001

Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2

Authors: Akasaka, Hironari, So, Shui-Ping, Ruan, Ke-He

Source: Biochemistry. 54(23):3707-3715

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN601596694&indx=1&recIds=ETOCRN601596694

IDENTIFICATION OF THE TWO-PHASE MECHANISM OF ENDOGENOUS OMEGA-6 FATTY ACID, ARACHIDONIC ACID, REGULATING VASCULAR INFLAMMATION BY TARGETING CYCLOOXYGENASE-2 AND MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1

Authors: Akasaka, Hironari, Ruan, Ke-He

Source: Journal of the American College of Cardiology. 67(16):2318-2318

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100056247721.0x000001&indx=1&recIds=ETOCvdc_100056247721.0x000001

A TRANSGENIC MOUSE MODEL EXPRESSING A NOVEL SINGLE-CHAIN ENZYME COMPLEX OF CYCLOOXYGENASE AND PROSTACYCLIN SYNTHASE EXHIBITS ROBUST RESISTANCE TO HEART DISEASE AND VASCULAR ASSAULT

Authors: Murdoch, Emma, Akasaka, Hironari, Ruan, Ke-He

Source: Journal of the American College of Cardiology. 67(16):2288-2288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100056247640.0x000001&indx=1&recIds=ETOCvdc_100056247640.0x000001

Fascicularones H–K, Four New Sesquiterpenoids from the Cultured Mycelia of the Fungus Hypholoma fasciculare

Authors: Akasaka, Hironari, Shiono, Yoshihito

Source: Helvetica Chimica Acta; November 2005, Vol. 88 Issue: 11 p2944-2950, 7p

Fascicularones H-K, Four New Sesquiterpenoids from the Cultured Mycelia of the Fungus Hypholoma fasciculare.

Authors: Akasaka, Hironari, Shiono, Yoshihito, Murayama, Tetsuya, Ikeda, Michimasa

Source: ChemInform; Apr2006, Vol. 37 Issue 15, pno-no, 1p

Three Sesquiterpenoids, Fascicularones E, F, and G Produced by the Fungus Hypholoma fasciculare.

Authors: Shiono, Yoshihito, Akasaka, Hironari, Hiramatsu, Fuminori, Sato, Kozue, Murayama, Tetsuya, Ikeda, Michimasa

Source: ChemInform; Jan2006, Vol. 37 Issue 1, pno-no, 1p