Efficacy, pharmacokinetics, and safety of subcutaneous C1-esterase inhibitor as prophylaxis in Japanese patients with hereditary angioedema: Results of a Phase 3 study

Authors: Fukuda, Tomoo, Yamagami, Keiko, Kawahata, Kimito, Suzuki, Yuzo, Sasaki, Yoshihiro, Miyagi, Takashi, Jacobs, Iris, Lawo, John-Philip, Glassman, Fiona, Akama, Hideto, Hide, Michihiro, Ohsawa, Isao

Source: In Allergology International July 2023 72(3):451-457

Phase 1 Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Garadacimab (CSL312) in Healthy Japanese and Caucasian Adults

Authors: Glassman, Fiona, Goodson, Summer, Bica, Alex, Roberts, Anthony, Akama, Hideto, Asami, Yumiko, Jain, Meena, Acharya, Milin

Source: Journal of allergy and clinical immunology. 151(2):AB144-AB144

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180526826.0x000001&indx=1&recIds=ETOCvdc_100180526826.0x000001

Efficacy of a novel phosphodiesterase inhibitor, E6005, in patients with atopic dermatitis: An investigator-blinded, vehicle-controlled study

Authors: Ohba, Fuminori, Matsuki, Shunji, Imayama, Shuhei, Matsuguma, Kyoko, Hojo, Seiichiro, Nomoto, Maiko, Akama, Hideto

Source: Journal of dermatological treatment. 27(5):467-472

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105242628.0x000001&indx=1&recIds=ETOCvdc_100105242628.0x000001

Safety, tolerability and pharmacokinetics of a novel phosphodiesterase inhibitor, E6005 ointment, in healthy volunteers and in patients with atopic dermatitis

Authors: Ohba, Fuminori, Nomoto, Maiko, Hojo, Seiichiro, Akama, Hideto

Source: Journal of dermatological treatment. 27(3):241-246

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105242234.0x000001&indx=1&recIds=ETOCvdc_100105242234.0x000001

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Mo1890 Safety, Tolerability and Efficacy of E6011, Anti-Human Fractalkine Monoclonal Antibody, in the First-in-Patient Study for Crohn's Disease

Authors: Matsuoka, Katsuyoshi, Naganuma, Makoto, Matsui, Toshiyuki, Arai, Makoto, Tanida, Satoshi, Kitamura, Kazuya, Horiki, Noriyuki, Fujiya, Mikihiro, Iimuro, Masaki, Mitsuyama, Keiichi, Saruta, Masayuki, Matsumoto, Takayuki, Nebiki, Hiroko, Esaki, Motohiro, Kinjo, Fukunori, Oketani, Kiyoshi, Hojo, Seiichiro, Akama, Hideto, Imai, Toshio, Tsubouchi, Hirohito, Hibi, Toshifumi, Kanai, Takanori

Source: In Gastroenterology April 2016 150(4) Supplement 1:S808-S808

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One third of Japanese patients with rheumatoid arthritis use complementary and alternative medicine.

Authors: Kajiyama, Hiroshi¹ hkajicongr@verizon.net, Akama, Hideto¹, Yamanaka, Hisashi¹, Shoji, Akira², Matsuda, Yuko¹, Tanaka, Eiichi¹, Nakajima, Ayako¹, Terai, Chihiro¹, Hara, Masako¹, Tomatsu, Taisuke¹, Saitoh, Terunobu¹, Kamatani, Naoyuki¹

Source: Modern Rheumatology. Dec2006, Vol. 16 Issue 6, p355-359. 5p. 3 Diagrams, 3 Charts.

Subject Terms: *RHEUMATOID arthritis, *ALTERNATIVE medicine, *PATIENT satisfaction, *COHORT analysis, *REGRESSION analysis, *PATIENTS

Geographic Terms: JAPAN

Suppression of Adjuvant-Induced Arthritic Bone Destruction by Cyclooxygenase-2 Selective Agents With and Without Inhibitory Potency Against Carbonic Anhydrase II.

Authors: Katagiri, Mika, Ogasawara, Toru, Hoshi, Kazuto, Chikazu, Daichi, Kimoto, Aishi, Noguchi, Masahiro, Sasamata, Masao, Harada, Shun-ichi, Akama, Hideto, Tazaki, Hatsue, Chung, Ung-il, Takato, Tsuyoshi, Nakamura, Kozo, Kawaguchi, Hiroshi

Source: Journal of Bone & Mineral Research; Feb2006, Vol. 21 Issue 2, p219-227, 9p

Multiple distal interphalangeal joint dislocation.

Alternate Title: clinical picture

Authors: Nanke, Yuki, Kotake, Shigeru, Akama, Hideto

Source: Lancet; November 4 2000, Vol. 356 Issue 9241, p1550-1550, 1p

A new syndrome: multiple dislocations of distal interphalangeal joints associated with interstitial pneumonia, Sjögren's syndrome, and positive autoantibodies.

Authors: Nanke, Yuki, Kotake, Shigeru, Akama, Hideto, Kamatani, Naoyuki

Source: Modern Rheumatology; Jun2003, Vol. 13 Issue 2, p103-106, 4p, 9 Black and White Photographs

Subject Terms: PULMONARY fibrosis, SJOGREN'S syndrome, AUTOANTIBODIES, JOINT dislocations, HUMAN abnormalities

Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses.

Authors: Urano, Wako, Taniguchi, Atsuo, Yamanaka, Hisashi, Tanaka, Eiichi, Nakajima, Hiroshi, Matsuda, Yuko, Akama, Hideto, Kitamura, Yutaka, Kamatani, Naoyuki

Source: Pharmacogenetics; Apr2002, Vol. 12 Issue 3, p183-190, 8p

Letters to the editor.

Authors: Schwartzman, Michael J., Mitsumoto, Hiroshi, Shields, Robert W., Estes, Melinda L., Meisler, David M., Kosmorsky, Gregory S., Akama, Hideto, Bromberg, Mark B., Katrirji, M. Bashar, Newsom-Davis, John, Oh, Shin J.

Source: Muscle & Nerve; 1990, Vol. 13 Issue 12, p1183-1186, 4p

Glucocorticoid receptor and inhibition of 3-O-methyl-D-glucose uptake by glucocorticoids in peripheral blood leukocytes from normal humans: correlation between receptor level and hormone effect in vitro

Authors: Tanaka, Hirotoshi, Akama, Hideto, Ichikawa, Yoichi, Homma, Mitsuo, Makino, Isao

Source: European Journal of Endocrinology; January 1992, Vol. 126 Issue: 1 p29-36, 8p

In vivo responsiveness to glucocorticoid correlated with glucocorticoid receptor content in peripheral blood leukocytes in normal humans

Authors: Tanaka, Hirotoshi, Ichikawa, Yoichi, Akama, Hideto, Homma, Mitsuo

Source: European Journal of Endocrinology; October 1989, Vol. 121 Issue: 4 p470-476, 7p

Human Complement Protein C2

Authors: Akama, Hideto, Johnson, Charles A.C., Colten, Harvey R.

Source: Journal of Biological Chemistry; February 1995, Vol. 270 Issue: 6 p2674-2678, 5p

Type II Human Complement C2 Deficiency

Authors: Wetsel, Rick A., Kulics, Judit, Lokki, Marja-Liisa, Kiepiela, Photini, Akama, Hideto, Johnson, Charles A.C., Densen, Peter, Colten, Harvey R.

Source: Journal of Biological Chemistry; March 1996, Vol. 271 Issue: 10 p5824-5831, 8p

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous and Intravenous Garadacimab Following Single‐Dose Administration in Healthy Japanese and White Adults.

Authors: Glassman, Fiona¹ (AUTHOR) Fiona.Glassman@cslbehring.com, Lawo, John‐Philip² (AUTHOR), Bica, Mihai Alexandru² (AUTHOR), Roberts, Anthony³ (AUTHOR), Pawaskar, Dipti⁴ (AUTHOR), Akama, Hideto⁵ (AUTHOR), Jain, Meena⁶ (AUTHOR), Goodson, Summer⁷ (AUTHOR)

Source: Journal of Clinical Pharmacology. Nov2024, p1. 12p. 4 Illustrations.

Subject Terms: *KALLIKREIN, *PHARMACODYNAMICS, *PHARMACOKINETICS, *ANGIONEUROTIC edema, *MONOCLONAL antibodies