User-friendly bioorthogonal reactions click to explore glycan functions in complex biological systems

Authors: Xi Chen, Ajit Varki

Source: The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/29073e7f922b4aa89938aa15ba62b7aa

Display of the human mucinome with defined O-glycans by gene engineered cells

Authors: Rebecca Nason, Christian Büll, Andriana Konstantinidi, Lingbo Sun, Zilu Ye, Adnan Halim, Wenjuan Du, Daniel M. Sørensen, Fabien Durbesson, Sanae Furukawa, Ulla Mandel, Hiren J. Joshi, Leo Alexander Dworkin, Lars Hansen, Leonor David, Tina M. Iverson, Barbara A. Bensing, Paul M. Sullam, Ajit Varki, Erik de Vries, Cornelis A. M. de Haan, Renaud Vincentelli, Bernard Henrissat, Sergey Y. Vakhrushev, Henrik Clausen, Yoshiki Narimatsu

Source: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/052ba3410c8a4710a0be9d4b267f2de3

Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression

Authors: Shoib S Siddiqui, Michael Vaill, Raymond Do, Naazneen Khan, Andrea L Verhagen, Wu Zhang, Heinz‐Josef Lenz, Teresa L Johnson‐Pais, Robin J Leach, Gary Fraser, Charles Wang, Gen‐Sheng Feng, Nissi Varki, Ajit Varki

Source: FASEB BioAdvances, Vol 3, Iss 2, Pp 69-82 (2021)

Subject Terms: advanced carcinoma, dot blot, immunohistochemistry, pseudogenization, SIGLEC12, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2573-9832

Access URL: https://doaj.org/article/ad2c6af5813f4af8ac528b23cfb4091c

N-glycolyl chondroitin synthesis using metabolically engineered E. coli

Authors: Adeola E. Awofiranye, Sultan N. Baytas, Ke Xia, Abinaya Badri, Wenqin He, Ajit Varki, Mattheos Koffas, Robert J. Linhardt

Source: AMB Express, Vol 10, Iss 1, Pp 1-9 (2020)

Subject Terms: Sialic acid, Biotransformation, N-glycolyl chondroitin, Metabolite, N-glycolyl glucosamine, Biotechnology, TP248.13-248.65, Microbiology, QR1-502

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13568-020-01084-6; https://doaj.org/toc/2191-0855

Access URL: https://doaj.org/article/e35747b0d7fc458284e207ed8b6585b4

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

Authors: Chih-Ming Tsai, Angelica M. Riestra, Syed Raza Ali, Jerry J. Fong, Janet Z. Liu, Gillian Hughes, Ajit Varki, Victor Nizet

Source: Journal of Innate Immunity, Pp 1-11 (2019)

Subject Terms: siglec, interleukin-1β, caspase-1, inflammasome, macrophages, innate immunity, vimentin, Medicine, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/504323; https://doaj.org/toc/1662-811X; https://doaj.org/toc/1662-8128

Access URL: https://doaj.org/article/63dfda95c85a47bda26bb2cfcbd82675

SARS-CoV-2 and MERS-CoV Spike Protein Binding Studies Support Stable Mimic of Bound 9-O-Acetylated Sialic Acids

Authors: Lisa Oh, Ajit Varki, Xi Chen, Lee-Ping Wang

Source: Molecules, Vol 27, Iss 16, p 5322 (2022)

Subject Terms: SARS-CoV-2, MERS-CoV, CoV S protein, sialic acid, MM-PBSA, SOMD, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/16/5322; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/ccb492c4ddd74a498cc816a7e59b856e

Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae

Authors: Sudeshna Saha, Alison Coady, Aniruddha Sasmal, Kunio Kawanishi, Biswa Choudhury, Hai Yu, Ricardo U. Sorensen, Jaime Inostroza, Ian C. Schoenhofen, Xi Chen, Anja Münster-Kühnel, Chihiro Sato, Ken Kitajima, Sanjay Ram, Victor Nizet, Ajit Varki

Source: mBio, Vol 12, Iss 1 (2021)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2161-2129; https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/55c19541bb674c079290b532f74dd4fb

Evolution of the exclusively human pathogen Neisseria gonorrhoeae: Human‐specific engagement of immunoregulatory Siglecs

Authors: Corinna S. Landig, Ashley Hazel, Benjamin P. Kellman, Jerry J. Fong, Flavio Schwarz, Sarika Agarwal, Nissi Varki, Paola Massari, Nathan E. Lewis, Sanjay Ram, Ajit Varki

Source: Evolutionary Applications, Vol 12, Iss 2, Pp 337-349 (2019)

Subject Terms: disease biology, evolutionary medicine, gonorrhea, microbial biology, polymorphism, population genetics, Evolution, QH359-425

File Description: electronic resource

Relation: https://doaj.org/toc/1752-4571

Access URL: https://doaj.org/article/c8cc1fd7cba147ddab7dba648b0c6a2d

Ongoing selection for a uniquely human null allele of SIGLEC12 in world‐wide populations may protect against the risk of advanced carcinomas

Authors: Shoib S. Siddiqui, Michael Vaill, Ajit Varki

Source: FASEB BioAdvances, Vol 3, Iss 4, Pp 278-279 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2573-9832

Access URL: https://doaj.org/article/3f2940619ace4fb287c775b657006960

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus

Authors: C. David Owen, Louise E. Tailford, Serena Monaco, Tanja Šuligoj, Laura Vaux, Romane Lallement, Zahra Khedri, Hai Yu, Karine Lecointe, John Walshaw, Sandra Tribolo, Marc Horrex, Andrew Bell, Xi Chen, Gary L. Taylor, Ajit Varki, Jesus Angulo, Nathalie Juge

Source: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a9e2f73219e849be977339d14d916fea

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates

Authors: Toshiyuki Hayakawa, Zahra Khedri, Flavio Schwarz, Corinna Landig, Suh-Yuen Liang, Hai Yu, Xi Chen, Naoko T. Fujito, Yoko Satta, Ajit Varki, Takashi Angata

Source: BMC Evolutionary Biology, Vol 17, Iss 1, Pp 1-11 (2017)

Subject Terms: Coevolution, Sialic acid, Paired receptors, Gene conversion, Primates, Evolution, QH359-425

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12862-017-1075-z; https://doaj.org/toc/1471-2148

Access URL: https://doaj.org/article/6d3bfaa1ab564971b6dafea15b540306

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation

Authors: Preston S. K. Ng, Christopher J. Day, John M. Atack, Lauren E. Hartley-Tassell, Linda E. Winter, Tal Marshanski, Vered Padler-Karavani, Ajit Varki, Stephen J. Barenkamp, Michael A. Apicella, Michael P. Jennings

Source: mBio, Vol 10, Iss 3 (2019)

Subject Terms: Haemophilus influenzae, bacterial metabolism, glycobiology, microbial pathogenesis, sialic acid, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/9df602e01e3944e69c87d40bbd3d2636

Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain

Authors: Vinay S. Mahajan, Ezana Demissie, Hamid Mattoo, Vinay Viswanadham, Ajit Varki, Robert Morris, Shiv Pillai

Source: Cell Reports, Vol 15, Iss 9, Pp 1901-1909 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716305253; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/f5eb8278bfdb484d8ca9eccbdaeb63bf

From 'Serum Sickness' to 'Xenosialitis': Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc

Authors: Chirag Dhar, Aniruddha Sasmal, Ajit Varki

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: Neu5Gc, anti-Neu5Gc, serum sickness, xenosialitis, red meat, sialic acid, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.00807/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/61053f02c6214321ac95fea4b93959be

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera.

Authors: Frederico Alisson-Silva, Janet Z Liu, Sandra L Diaz, Lingquan Deng, Mélanie G Gareau, Ronald Marchelletta, Xi Chen, Victor Nizet, Nissi Varki, Kim E Barrett, Ajit Varki

Source: PLoS Pathogens, Vol 14, Iss 6, p e1007133 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6023241?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/d8eece3bd5ab40258f018d5c5185de58

Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins

Authors: Martijn A. Langereis, Mark J.G. Bakkers, Lingquan Deng, Vered Padler-Karavani, Stephin J. Vervoort, Ruben J.G. Hulswit, Arno L.W. van Vliet, Gerrit J. Gerwig, Stefanie A.H. de Poot, Willemijn Boot, Anne Marie van Ederen, Balthasar A. Heesters, Chris M. van der Loos, Frank J.M. van Kuppeveld, Hai Yu, Eric G. Huizinga, Xi Chen, Ajit Varki, Johannis P. Kamerling, Raoul J. de Groot

Source: Cell Reports, Vol 11, Iss 12, Pp 1966-1978 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221112471500580X; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/c810e7e811be4ad3b07b1a33d7f7d1fb

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.

Authors: Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki

Source: PLoS ONE, Vol 13, Iss 6, p e0197464 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/424df0382778463286c9255771ab2f43

Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus

Authors: Brian R. Wasik, Karen N. Barnard, Robert J. Ossiboff, Zahra Khedri, Kurtis H. Feng, Hai Yu, Xi Chen, Daniel R. Perez, Ajit Varki, Colin R. Parrish

Source: mSphere, Vol 2, Iss 5 (2017)

Subject Terms: host range, influenza, receptor-ligand interaction, respiratory viruses, sialic acid, virus-host interactions, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5042

Access URL: https://doaj.org/article/fc6ce7f68e4b4ef8a04c462e9d7f2cac

Correction: An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.

Authors: Hao Song, Jianxun Qi, Zahra Khedri, Sandra Diaz, Hai Yu, Xi Chen, Ajit Varki, Yi Shi, George F Gao

Source: PLoS Pathogens, Vol 12, Iss 3, p e1005505 (2016)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4782993?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/63e2fb849bca49eb95ed78c8ab653247

An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.

Authors: Hao Song, Jianxun Qi, Zahra Khedri, Sandra Diaz, Hai Yu, Xi Chen, Ajit Varki, Yi Shi, George F Gao

Source: PLoS Pathogens, Vol 12, Iss 1, p e1005411 (2016)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4729479?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/cb9b7b9c8938494cb05775cd4e44d294