The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials

Authors: Jonathan I. Silverberg, David Rosmarin, Raj Chovatiya, Thomas Bieber, Stephen Schleicher, Lisa Beck, Melinda Gooderham, Sohail Chaudhry, Christie Fanton, Danni Yu, Joshua Levy, Yi Liu, Takahiro Miyazaki, Mary Tagliaferri, Carsten Schmitz, Ajay Nirula, Brian Kotzin, Jonathan Zalevsky

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/9bc93354dab940bc992d2c583c1fb98c

Efficacy and Safety of Low-Dose, Rapidly Infused Bamlanivimab and Etesevimab: Phase 3 BLAZE-1 Trial for Mild-to-Moderate COVID-19

Authors: Dipak R. Patel, Lisa Macpherson, Martin Bohm, Himanshu Upadhyaya, Carmen Deveau, Ajay Nirula, Paul Klekotka, Mark Williams, Matthew M. Hufford

Source: Infectious Diseases and Therapy, Vol 13, Iss 10, Pp 2123-2134 (2024)

Subject Terms: Bamlanivimab, BLAZE-1, Clinical trial, COVID-19, Etesevimab, Treatment, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8229; https://doaj.org/toc/2193-6382

Access URL: https://doaj.org/article/cf567da4bb5443c981f49175bf36b985

Systematic literature review on early clinical evidence for immune-resolution therapies and potential benefits to patients and healthcare providers

Authors: Paul Klekotka, Louis Lavoie, Beth Mitchell, Ike Iheanacho, Russel Burge, Andrea Cohee, Joanne Puckett, Ajay Nirula

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: asthma, atopic dermatitis, immune resolution, rheumatoid arthritis, SLE - systemic lupus erythematosus, ulcerative colitis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1425478/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4365c4d5d25c46fdb6aac5bf7520a9c3

Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19

Authors: Kara W. Chew, Carlee Moser, Eric S. Daar, David A. Wohl, Jonathan Z. Li, Robert W. Coombs, Justin Ritz, Mark Giganti, Arzhang Cyrus Javan, Yijia Li, Manish C. Choudhary, Rinki Deo, Carlos Malvestutto, Paul Klekotka, Karen Price, Ajay Nirula, William Fischer, Veenu Bala, Ruy M. Ribeiro, Alan S. Perelson, Courtney V. Fletcher, Joseph J. Eron, Judith S. Currier, ACTIV-2/A5401 Study Team, Michael D. Hughes, Davey M. Smith

Source: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0b6a4f1c3538405a88228d712db0338b

Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients

Authors: Justin Stebbing, Venkatesh Krishnan, Stephanie de Bono, Silvia Ottaviani, Giacomo Casalini, Peter J Richardson, Vanessa Monteil, Volker M Lauschke, Ali Mirazimi, Sonia Youhanna, Yee‐Joo Tan, Fausto Baldanti, Antonella Sarasini, Jorge A Ross Terres, Brian J Nickoloff, Richard E Higgs, Guilherme Rocha, Nicole L Byers, Douglas E Schlichting, Ajay Nirula, Anabela Cardoso, Mario Corbellino, the Sacco Baricitinib Study Group

Source: EMBO Molecular Medicine, Vol 12, Iss 8, Pp 1-15 (2020)

Subject Terms: anti‐cytokine, anti‐viral, baricitinib, case series, COVID‐19, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/1380cc483c5c41d9b6607430fabfaf22

COVID-19 symptom relationship to antibody response and ACE2 neutralization in recovered health systems employees before and after mRNA BNT162b2 COVID-19 vaccine

Authors: Gregory Huhn, Josh Poorbaugh, Lin Zhang, Stephanie Beasley, Ajay Nirula, Jennifer Brothers, Sharon Welbel, James Wilson, Sheena Gillani, Kathleen M. Weber, Ralph Morack, Kody Keckler, Robert J. Benschop

Source: PLoS ONE, Vol 17, Iss 9 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462709/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a5cae4cf70494a3f8c5b1cc1795dd4a5

Publisher Correction: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19

Authors: Kara W. Chew, Carlee Moser, Eric S. Daar, David A. Wohl, Jonathan Z. Li, Robert W. Coombs, Justin Ritz, Mark Giganti, Arzhang Cyrus Javan, Yijia Li, Manish C. Choudhary, Rinki Deo, Carlos Malvestutto, Paul Klekotka, Karen Price, Ajay Nirula, William Fischer, Veenu Bala, Ruy M. Ribeiro, Alan S. Perelson, Courtney V. Fletcher, Joseph J. Eron, Judith S. Currier, ACTIV-2/A5401 Study Team, Michael D. Hughes, Davey M. Smith

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/855e78e2e14745259e95ef61051904bc

Endogenous Antibody Responses to SARS-CoV-2 in Patients With Mild or Moderate COVID-19 Who Received Bamlanivimab Alone or Bamlanivimab and Etesevimab Together

Authors: Lin Zhang, Josh Poorbaugh, Michael Dougan, Peter Chen, Robert L. Gottlieb, Gregory Huhn, Stephanie Beasley, Montanea Daniels, Thi Ngoc Vy Trinh, Melissa Crisp, Joshua Joaquin Freitas, Peter Vaillancourt, Dipak R. Patel, Ajay Nirula, Nicole L. Kallewaard, Richard E. Higgs, Robert J. Benschop

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: serology, antibodies, immune response, COVID-19, bamlanivimab, etesevimab, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.790469/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/2989bd8ebc794edc93eb3dcb73825ce6

Lymphotoxin-LIGHT pathway regulates the interferon signature in rheumatoid arthritis.

Authors: Jadwiga Bienkowska, Norm Allaire, Alice Thai, Jaya Goyal, Tatiana Plavina, Ajay Nirula, Megan Weaver, Charlotte Newman, Michelle Petri, Evan Beckman, Jeffrey L Browning

Source: PLoS ONE, Vol 9, Iss 11, p e112545 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4236099?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5aee8698067a47a9b3e3c6ff98a387d3

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