Integrative analysis of miRNAs and proteins in plasma extracellular vesicles of patients with familial hypercholesterolemia

Authors: Freitas, Renata Caroline Costa de ^{a, b}, Bortolin, Raul Hernandes ^{a, c}, Kuraoka, Shiori ^d, Rogers, Maximillian A. ^d, Blaser, Mark C. ^d, Chelvanambi, Sarvesh ^d, Borges, Jessica Bassani ^e, Oliveira, Victor Fernandes de ^a, Dagli-Hernandez, Carolina ^a, Bastos, Gisele Medeiros ^e, Marçal, Elisangela da Silva Rodrigues ^{a, f}, Malaquias, Vanessa Barbosa ^a, Gonçalves, Rodrigo Marques ^g, Faludi, Andre Arpad ^g, Silbiger, Vivian Nogueira ^{h, i}, Luchessi, André Ducati ^{h, i}, Aikawa, Masanori ^d, Hirata, Rosario Dominguez Crespo ^a, Singh, Sasha A. ^{d, 1}, Aikawa, Elena ^{d, j, 1}, Hirata, Mario Hiroyuki ^{a, 1, ⁎}

Source: In Clinica Chimica Acta 15 February 2025 568

Nutrient supplementation mitigates retinal dysfunction in Acox1 knockout mice with impaired peroxisomal fatty acid oxidation

Authors: Boeck, Myriam ^{a, b}, Yagi, Hitomi ^{a, c}, Chen, Chuck T. ^d, Zeng, Yan ^a, Lee, Deokho ^a, Nian, Shen ^{a, e}, Kasai, Taku ^f, Lee, Jeff ^a, Hirst, Victoria ^a, Wang, Chaomei ^a, Neilsen, Katherine ^a, Rodrick, Tori C. ^g, McCutcheon, Andrew ^d, Yu, Mathew ^d, Lodhi, Irfan J. ^h, Singh, Sasha A. ^f, Aikawa, Masanori ^{f, i, j}, Bazinet, Richard P. ^d, Fu, Zhongjie ^{a, ⁎}

Source: In Journal of Advanced Research March 2025

Elevated lipoprotein(a) as a predictor for coronary events in older men

Authors: Bartoli-Leonard, Francesca, Turner, Mandy E., Zimmer, Jonas, Chapurlat, Roland, Pham, Tan, Aikawa, Masanori, Pradhan, Aruna D., Szulc, Pawel, Aikawa, Elena

Source: In Journal of Lipid Research August 2022 63(8)

Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression.

Authors: Boucher, Dominique M., Robichaud, Sabrina, Lorant, Victoria, Leon, Jonathan S., Suliman, Issraa, Rasheed, Adil, Susser, Leah I., Emerton, Christina, Geoffrion, Michele, De Jong, Erica, Bowdish, Dawn M.E., Aikawa, Masanori, Aikawa, Elena, Singh, Sasha A., Rayner, Katey J., Ouimet, Mireille

Source: Arteriosclerosis, Thrombosis & Vascular Biology; Apr2025, Vol. 45 Issue 4, p481-495, 15p

In‐Source Collision‐Induced Dissociation (CID) Improves Higher‐Energy Collisional Dissociation (HCD)‐Dependent Fragmentation of ADP‐Ribosyl Peptides.

Authors: Kasai, Taku, Nakamura, Yuto, Aikawa, Masanori, Singh, Sasha A.

Source: Rapid Communications in Mass Spectrometry: RCM; 2/28/2025, Vol. 39 Issue 4, p1-10, 10p

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling

Authors: Decano, Julius L., Iwamoto, Yukio, Goto, Shinji, Lee, Janey Y., Matamalas, Joan T., Halu, Arda, Blaser, Mark, Lee, Lang Ho, Pieper, Brett, Chelvanambi, Sarvesh, Silva-Nicolau, Jessica, Bartoli-Leonard, Francesca, Higashi, Hideyuki, Shibata, Haruki, Vyas, Payal, Wang, Jianguo, Gostjeva, Elena, Body, Simon C., Singh, Sasha A., Aikawa, Masanori, Aikawa, Elena

Source: In Cell Reports 12 April 2022 39(2)

A Novel Spectral Annotation Strategy Streamlines Reporting of Mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ

Authors: Kuraoka, Shiori, Higashi, Hideyuki, Yanagihara, Yoshihiro, Sonawane, Abhijeet R., Mukai, Shin, Mlynarchik, Andrew K., Whelan, Mary C., Hottiger, Michael O., Nasir, Waqas, Delanghe, Bernard, Aikawa, Masanori, Singh, Sasha A.

Source: In Molecular & Cellular Proteomics April 2022 21(4)

Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms

Authors: Katsuki, Shunsuke, K. Jha, Prabhash, Lupieri, Adrien, Nakano, Toshiaki, Passos, Livia S.A., Rogers, Maximillian A., Becker-Greene, Dakota, Le, Thanh-Dat, Decano, Julius L., Ho Lee, Lang, Guimaraes, Gabriel C., Abdelhamid, Ilyes, Halu, Arda, Muscoloni, Alessandro, V. Cannistraci, Carlo, Higashi, Hideyuki, Zhang, Hengmin, Vromman, Amélie, Libby, Peter, Keith Ozaki, C., Sharma, Amitabh, Singh, Sasha A., Aikawa, Elena, Aikawa, Masanori

Source: Circulation research. 131(11):873-889

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185465558.0x000001&indx=1&recIds=ETOCvdc_100185465558.0x000001

Second Heart Field–Derived Cells Contribute to Angiotensin II–Mediated Ascending Aortopathies

Authors: Sawada, Hisashi, Katsumata, Yuriko, Higashi, Hideyuki, Zhang, Chen, Li, Yanming, Morgan, Stephanie, Lee, Lang H., Singh, Sasha A., Chen, Jeff Z., Franklin, Michael K., Moorleghen, Jessica J., Howatt, Deborah A., Rateri, Debra L., Shen, Ying H., LeMaire, Scott A., Aikawa, Masanori, Majesky, Mark W., Lu, Hong S., Daugherty, Alan

Source: Circulation. 145(13):987-1001

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155508703.0x000001&indx=1&recIds=ETOCvdc_100155508703.0x000001

Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model

Authors: Ruiz, Jessica L., Hutcheson, Joshua D., Cardoso, Luis, Nik, Amirala Bakhshian, de Abreu, Alexandra Condado, Pham, Tan, Buffolo, Fabrizio, Busatto, Sara, Federicih, Stefania, Ridolfi, Andrea, Aikawa, Masanori, Bertazzo, Sergio, Bergese, Paolo, Weinbaum, Sheldon, Aikawa, Elena

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Apr 01. 118(14), 1-10.

Access URL: https://www.jstor.org/stable/27039700

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Authors: Brandão, Simone Cristina Soares ^*, Ramos, Júlia de Oliveira Xavier, Dompieri, Luca Terracini, Godoi, Emmanuelle Tenório Albuquerque Madruga, Figueiredo, José Luiz, Sarinho, Emanuel Sávio Cavalcanti, Chelvanambi, Sarvesh, Aikawa, Masanori

Source: In Cytokine and Growth Factor Reviews April 2021 58:102-110

ApoC-III is a novel inducer of calcification in human aortic valves

Authors: Schlotter, Florian, de Freitas, Renata C.C., Rogers, Maximillian A., Blaser, Mark C., Wu, Pin-Jou, Higashi, Hideyuki, Halu, Arda, Iqbal, Farwah, Andraski, Allison B., Rodia, Cayla N., Kuraoka, Shiori, Wen, Jennifer R., Creager, Michael, Pham, Tan, Hutcheson, Joshua D., Body, Simon C., Kohan, Alison B., Sacks, Frank M., Aikawa, Masanori, Singh, Sasha A., Aikawa, Elena

Source: In Journal of Biological Chemistry January-June 2021 296

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions.

Authors: Sun, Jun¹ (AUTHOR) lmiele@lsuhsc.edu, Aikawa, Masanori² (AUTHOR), Ashktorab, Hassan³ (AUTHOR), Beckmann, Noam D.^4,5 (AUTHOR), Enger, Michael L.⁶ (AUTHOR), Espinosa, Joaquin M.⁷ (AUTHOR), Gai, Xiaowu^8,9 (AUTHOR), Horne, Benjamin D.^10,11 (AUTHOR), Keim, Paul^12,13,14 (AUTHOR), Lasky-Su, Jessica¹⁵ (AUTHOR), Letts, Rebecca¹⁶ (AUTHOR), Maier, Cheryl L.¹⁷ (AUTHOR), Mandal, Meisha⁶ (AUTHOR), Nichols, Lauren¹⁶ (AUTHOR), Roan, Nadia R.^18,19 (AUTHOR), Russell, Mark W.²⁰ (AUTHOR), Rutter, Jacqueline¹⁶ (AUTHOR), Saade, George R.^21,22 (AUTHOR), Sharma, Kumar^23,24 (AUTHOR), Shiau, Stephanie²⁵ (AUTHOR)

Source: Frontiers in Systems Biology. 2025, p1-13. 13p.

Subject Terms: *POST-acute COVID-19 syndrome, *SYSTEMS biology, *SOCIAL determinants of health, *TASK forces, *CHILD patients, *BIOMARKERS

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery.

Authors: Halu, Arda, Chelvanambi, Sarvesh, Decano, Julius L., Matamalas, Joan T., Whelan, Mary, Asano, Takaharu, Kalicharran, Namitra, Singh, Sasha A., Loscalzo, Joseph, Aikawa, Masanori

Source: Genome Medicine; 1/20/2025, Vol. 17 Issue 1, p1-24, 24p

Subject Terms: DRUG discovery, CHEMICAL libraries, RECEIVER operating characteristic curves, LIFE sciences, GENE expression profiling, PHARMACOGENOMICS

Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion

Authors: Rogers, Maximillian A, Hutcheson, Joshua D, Okui, Takehito, Goettsch, Claudia, Singh, Sasha A, Halu, Arda, Schlotter, Florian, Higashi, Hideyuki, Wang, Lixiang, Whelan, Mary C, Mlynarchik, Andrew K, Daugherty, Alan, Nomura, Masatoshi, Aikawa, Masanori, Aikawa, Elena

Source: Cardiovascular research. 117(11):2340-2353

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100142818110.0x000001&indx=1&recIds=ETOCvdc_100142818110.0x000001

Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease

Authors: Decano, Julius L., Singh, Sasha A., Gasparotto Bueno, Cauê, Ho Lee, Lang, Halu, Arda, Chelvanambi, Sarvesh, Matamalas, Joan T., Zhang, Hengmin, Mlynarchik, Andrew K., Qiao, Jiao, Sharma, Amitabh, Mukai, Shin, Wang, Jianguo, Anderson, Daniel G., Ozaki, C. Keith, Libby, Peter, Aikawa, Elena, Aikawa, Masanori

Source: Circulation. 143(25):2454-2470

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189171893.0x000001&indx=1&recIds=ETOCvdc_100189171893.0x000001

CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction

Authors: Okui, Takehito, Iwashita, Masaya, Rogers, Maximillian A., Halu, Arda, Atkins, Samantha K., Kuraoka, Shiori, Abdelhamid, Ilyes, Higashi, Hideyuki, Ramsaroop, Ashisha, Aikawa, Masanori, Singh, Sasha A., Aikawa, Elena

Source: Arteriosclerosis, thrombosis, and vascular biology. 41(2):755-768

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180891132.0x000001&indx=1&recIds=ETOCvdc_100180891132.0x000001

Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease

Authors: Iqbal, Farwah, Lupieri, Adrien, Aikawa, Masanori, Aikawa, Elena

Source: Arteriosclerosis, thrombosis, and vascular biology. 41(2):585-600

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100180891029.0x000001&indx=1&recIds=ETOCvdc_100180891029.0x000001

Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice.

Authors: Kip, Peter, Sluiter, Thijs J., MacArthur, Michael R., Tao, Ming, Kruit, Nicky, Mitchell, Sarah J., Jung, Jonathan, Kooijman, Sander, Gorham, Josh, Seidman, Jonathan G., Quax, Paul H. A., Decano, Julius L., Aikawa, Masanori, Ozaki, C. Keith, Mitchell, James R., de Vries, Margreet R.

Source: Nature Communications; 11/7/2024, Vol. 15 Issue 1, p1-19, 19p

Subject Terms: VASCULAR remodeling, BROWN adipose tissue, THORACIC aorta, TRANSPLANTATION of organs, tissues, etc., VEIN surgery

Gene expression profiles of precursor cells identify compounds that reduce NRP1 surface expression in macrophages: Implication for drug repositioning for COVID-19.

Authors: Iwata, Akira, Chelvanambi, Sarvesh, Asano, Takaharu, Whelan, Mary, Nakamura, Yuto, Aikawa, Elena, Sasaki, Yusuke, Aikawa, Masanori

Source: Frontiers in Cardiovascular Medicine; 2024, p1-12, 12p