The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon

Authors: Shen, Chen, Nayak, Anmada, Neitzel, Leif R., Yang, Fan, Li, Bin, Williams, Charles H., Hong, Charles C., Ahmed, Yashi, Lee, Ethan, Robbins, David J.

Source: In Journal of Biological Chemistry August 2022 298(8)

Wnt signalosomes: What we know that we do not know.

Authors: Hartmann, Heather, Siddiqui, Ghalia Saad, Bryant, Jamal, Robbins, David J., Weiss, Vivian L., Ahmed, Yashi, Lee, Ethan

Source: BioEssays; Feb2025, Vol. 47 Issue 2, p1-11, 11p

Subject Terms: WNT signal transduction, CATENINS, NEOPLASTIC cell transformation, GENETIC transcription regulation, CELLULAR signal transduction, DOWNREGULATION, UBIQUITINATION, TERTIARY structure

Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A

Authors: Shen, Chen ^{1, 8}, Lu, Wenhui ^{1, 8}, Merugu, Siva B. ^{1, 8}, Bharti, Aradhana ¹, Afify, Said M. ¹, Schnitkey, Lauren ², Wynn, Daniel T. ¹, Yang, Fan ¹, Rohwetter, Thomas M. ¹, Nayak, Anmada ¹, Bunnag, Nawat ³, Cywiak, Carolina ², Tang, Hsin-Yao ⁴, Harris, Brent T. ¹, Albanese, Christopher ^{1, 5}, Ihemelandu, Chukwuemeka ⁶, Cobb, Melanie H. ⁷, Kettenbach, Arminja ³, Lee, Ethan ², Ahmed, Yashi ³, Robbins, David J. ^{1, 9, ∗}

Source: In Cell Reports 25 February 2025 44(2)

Developmental regulation of Wnt signaling by Nagk and the UDP-GlcNAc salvage pathway

Authors: Neitzel, Leif R., Spencer, Zachary T., Nayak, Anmada, Cselenyi, Christopher S., Benchabane, Hassina, Youngblood, CheyAnne Q., Zouaoui, Alya, Ng, Victoria, Stephens, Leah, Hann, Trevor, Patton, James G., Robbins, David, Ahmed, Yashi, Lee, Ethan

Source: In Mechanisms of Development April 2019 156:20-31

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway

Authors: Saito-Diaz, Kenyi, Benchabane, Hassina, Tiwari, Ajit, Tian, Ai, Li, Bin, Thompson, Joshua J., Hyde, Annastasia S., Sawyer, Leah M., Jodoin, Jeanne N., Santos, Eduardo, Lee, Laura A., Coffey, Robert J., Beauchamp, R. Daniel, Williams, Christopher S., Kenworthy, Anne K., Robbins, David J., Ahmed, Yashi, Lee, Ethan

Source: In Developmental Cell 12 March 2018 44(5):566-581

Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway.

Authors: Ando, Tomoaki, Takazawa, Ikuo, Spencer, Zachary T., Ito, Ryoji, Tomimori, Yoshiaki, Mikulski, Zbigniew, Matsumoto, Kenji, Ishitani, Tohru, Denson, Lee A., Kawakami, Yu, Kawakami, Yuko, Kitaura, Jiro, Ahmed, Yashi, Kawakami, Toshiaki

Source: Cells (2073-4409); Jun2024, Vol. 13 Issue 11, p986, 26p

Subject Terms: CROHN'S disease, ENTERITIS, INFLAMMATORY bowel diseases, CATENINS, CELLULAR signal transduction, INTESTINAL mucosa, PHOSPHOLIPASES

The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.

Authors: Spencer, Zachary T., Ng, Victoria H., Benchabane, Hassina, Siddiqui, Ghalia Saad, Duwadi, Deepesh, Maines, Ben, Bryant, Jamal M., Schwarzkopf, Anna, Yuan, Kai, Kassel, Sara N., Mishra, Anant, Pimentel, Ashley, Lebensohn, Andres M., Rohatgi, Rajat, Gerber, Scott A., Robbins, David J., Lee, Ethan, Ahmed, Yashi

Source: Nature Communications; 10/5/2023, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: DEUBIQUITINATING enzymes, WNT signal transduction, GENETIC regulation, CATENINS, ANIMAL development, UBIQUITINATION, DROSOPHILA

Dual Positive and Negative Regulation of Wingless Signaling by Adenomatous Polyposis Coli

Authors: Takacs, Carter M., Baird, Jason R., Hughes, Edward G., Kent, Sierra S., Benchabane, Hassina, Paik, Raehum, Ahmed, Yashi

Source: Science, 2008 Jan . 319(5861), 333-336.

Access URL: https://www.jstor.org/stable/20052027

A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila.

Authors: Zhenghan Wang¹, Tacchelly-Benites, Ofelia¹, Noble, Geoffrey P.¹, Johnson, Megan K.¹, Gagné, Jean-Philippe¹, Poirier, Guy G.¹, Ahmed, Yashi¹, yfa@dartmouth.edu

Source: Genetics; Mar2019, Vol. 211 Issue 3, p913-923, 11p

Villin Sequence and Peptide Map Identify Six Homologous Domains

Authors: Bazari, Wendy Levoy, Matsudaira, Paul, Wallek, Malgorzata, Smeal, Tod, Jakes, Ross, Ahmed, Yashi

Source: Proceedings of the National Academy of Sciences of the United States of America, 1988 Jul . 85(14), 4986-4990.

Access URL: https://www.jstor.org/stable/32343

USP47 deubiquitylates Groucho/TLE to promote Wnt–β-catenin signaling.

Authors: Kassel, Sara, Hanson, Alison J., Benchabane, Hassina, Saito-Diaz, Kenyi, Cabel, Carly R., Goldsmith, Lily, Taha, Muhammad, Kanuganti, Aksheta, Ng, Victoria H., Xu, George, Ye, Fei, Picker, Julia, Port, Fillip, Boutros, Michael, Weiss, Vivian L., Robbins, David J., Thorne, Curtis A., Ahmed, Yashi, Lee, Ethan

Source: Science Signaling; 2/7/2023, Vol. 16 Issue 771, p1-10, 10p

Subject Terms: WNT signal transduction, UBIQUITIN ligases, WNT genes, GENE expression, DROSOPHILA melanogaster, UBIQUITINATION

Feedback in the β-catenin destruction complex imparts bistability and cellular memory.

Authors: Jo Cantoria, Mary, Alizadeh, Elaheh, Ravi, Janani, Varghese, Reeba P., Bunnag, Nawat, Pond, Kelvin W., Kettenbach, Arminja N., Ahmed, Yashi, Paek, Andrew L., Tyson, John J., Doubrovinski, Konstantin, Lee, Ethan, Thorne, Curtis A.

Source: Proceedings of the National Academy of Sciences of the United States of America; 1/10/2023, Vol. 120 Issue 2, p1-8, 29p

Subject Terms: GLYCOGEN synthase kinase, SCAFFOLD proteins, PROTEIN kinases, MEMORY

Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization.

Authors: Tian, Ai¹, Duwadi, Deepesh¹, Benchabane, Hassina¹, Ahmed, Yashi¹, yfa@dartmouth.edu

Source: PLoS Genetics; 6/13/2019, Vol. 15 Issue 6, p1-30, 30p

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.

Authors: Zhenghan Wang¹, Tacchelly-Benites, Ofelia¹, Eungi Yang¹, Thorne, Curtis A.², Hisashi Nojima³, Lee, Ethan^2,4, Ahmed, Yashi¹, yfa@dartmouth.edu

Source: Genetics; May2016, Vol. 203 Issue 1, p269-281, 15p

Regulation of Armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.

Authors: Ahmed, Yashi, Hayashi, Shigemi, Levine, Arnold

Source: Cell; June 26 1998, Vol. 93 Issue 7, p1171-1182, 12p

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.

Authors: Shen, Chen, Nayak, Anmada, Neitzel, Leif R., Adams, Amber A., Silver-Isenstadt, Maya, Sawyer, Leah M., Benchabane, Hassina, Wang, Huilan, Bunnag, Nawat, Li, Bin, Wynn, Daniel T., Yang, Fan, Garcia-Contreras, Marta, Williams, Charles H., Dakshanamurthy, Sivanesan, Hong, Charles C., Ayad, Nagi G., Capobianco, Anthony J., Ahmed, Yashi, Lee, Ethan

Source: Nature Communications; 9/6/2021, Vol. 12 Issue 1, p1-10, 10p

Subject Terms: WNT signal transduction, UBIQUITIN ligases, CASEIN kinase, CELLULAR signal transduction, PROTEOLYSIS, MULTIPLE myeloma

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC.

Authors: Tacchelly-Benites, Ofelia¹, yfa@dartmouth.edu, Wang, Zhenghan¹, Yang, Eungi¹, Benchabane, Hassina¹, Tian, Ai¹, Randall, Michael P.¹, Ahmed, Yashi¹

Source: PLoS Genetics; 2/6/2018, Vol. 14 Issue 2, p1-24, 24p

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.

Authors: Tian, Ai¹, Benchabane, Hassina¹, Wang, Zhenghan¹, Zimmerman, Chloe¹, Xin, Nan¹, Perochon, Jessica², Kalna, Gabriela³, Sansom, Owen J.⁴, Cheng, Chao⁵, Cordero, Julia B.², Ahmed, Yashi¹, yfa@dartmouth.edu

Source: PLoS Genetics; 7/14/2017, Vol. 13 Issue 7, p1-37, 37p

Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling.

Authors: Wang, Zhenghan¹, Tacchelly-Benites, Ofelia¹, yfa@dartmouth.edu, Yang, Eungi¹, Ahmed, Yashi¹

Source: PLoS Genetics; 12/13/2016, Vol. 12 Issue 12, p1-26, 26p

Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries.

Authors: Tian, Ai¹, Benchabane, Hassina¹, Wang, Zhenghan¹, Ahmed, Yashi¹, yfa@dartmouth.edu

Source: PLoS Genetics; 2/4/2016, Vol. 12 Issue 2, p1-31, 31p