A simplified tutorial on charged aerosol detection: Understanding the basics, optimization, and troubleshooting

Authors: Barnhart, Wesley W., Farooq, Muhammad Qamar, Ahmad, Imad A. Haidar

Source: In Journal of Chromatography Open November 2024 6

Improved assay development of pharmaceutical modalities using feedback-controlled liquid chromatography optimization

Authors: Naser Aldine, Fatima, Singh, Andrew N., Wang, Heather, Makey, Devin M., Barrientos, Rodell C., Wong, Michelle, Aggarwal, Pankaj, Regalado, Erik L., Ahmad, Imad A. Haidar

Source: In Journal of Chromatography A 10 May 2024 1722

Enantioselective UHPLC Screening Combined with In Silico Modeling for Streamlined Development of Ultrafast Enantiopurity Assays

Authors: Losacco, Gioacchino Luca, Wang, Heather, Ahmad, Imad A. Haidar, DaSilva, Jimmy, Makarov, Alexey A., Mangion, Ian, Gasparrini, Francesco, Lämmerhofer, Michael, Armstrong, Daniel W., Regalado, Erik L.

Source: Analytical chemistry. 94(3):1804-1812

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Deuterated Modifiers in Sub/Supercritical Fluid Chromatography for Streamlined NMR Structure Elucidation

Authors: Losacco, Gioacchino Luca, Cohen, Ryan D., DaSilva, Jimmy O., Ahmad, Imad A. Haidar, Sherer, Edward C., Mangion, Ian, Regalado, Erik L.

Source: Analytical chemistry. 94(35):12176-12184

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Generic reversed‐phase ultra‐high‐pressure liquid chromatography methodology developed by using computer‐assisted modeling for streamlined performance evaluation of a wide range of stationary phase columns

Authors: Ahmad, Imad A. Haidar, Losacco, Gioacchino Luca, Figus, Margaret, Korani, Deepa, Gunsch, Matthew J., Lhotka, Hayley R., Hullen, Kari, Hartman, Robert, Lohani, Sachin, Hamilton, Simon, Mangion, Ian, Regalado, Erik L.

Source: Separation science plus. 5(5):138-145

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In Silico Method Development of Achiral and Chiral Tandem Column Reversed-phase Liquid Chromatography for Multicomponent Pharmaceutical Mixtures

Authors: Ahmad, Imad A. Haidar, Kiffer, Alaina, Barrientos, Rodell C., Losacco, Gioacchino Luca, Singh, Andrew, Shchurik, Vladimir, Wang, Heather, Mangion, Ian, Regalado, Erik L.

Source: Analytical chemistry. 94(9):4065-4071

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In Silico Multifactorial Modeling for Streamlined Development and Optimization of Two-Dimensional Liquid Chromatography

Authors: Ahmad, Imad A. Haidar, Makey, Devin M., Wang, Heather, Shchurik, Vladimir, Singh, Andrew N., Stoll, Dwight R., Mangion, Ian, Regalado, Erik L.

Source: Analytical chemistry. 93(33):11532-11539

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Mapping the Separation Landscape in Two-Dimensional Liquid Chromatography: Blueprints for Efficient Analysis and Purification of Pharmaceuticals Enabled by Computer-Assisted Modeling

Authors: Makey, Devin M., Shchurik, Vladimir, Wang, Heather, Lhotka, Hayley R., Stoll, Dwight R., Vazhentsev, Andrey, Mangion, Ian, Regalado, Erik L., Ahmad, Imad A. Haidar

Source: Analytical chemistry. 93(2):964-972

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Introducing Multifactorial Peak Crossover in Analytical and Preparative Chromatography via Computer-Assisted Modeling

Authors: Ahmad, Imad A. Haidar, Shchurik, Vladimir, Nowak, Timothy, Mann, Benjamin F., Regalado, Erik L.

Source: Analytical chemistry. 92(19):13443-13451

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Mapping the Separation Landscape of Pharmaceuticals: Rapid and Efficient Scale-Up of Preparative Purifications Enabled by Computer-Assisted Chromatographic Method Development

Authors: Bennett, Raffeal, Ahmad, Imad A. Haidar, DaSilva, Jimmy, Figus, Margaret, Hullen, Kari, Tsay, Fuh-Rong, Makarov, Alexey A., Mann, Benjamin F., Regalado, Erik L.

Source: Organic process research & development. 23(12):2678-2684

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Chaotropic Effects in Sub/Supercritical Fluid Chromatography via Ammonium Hydroxide in Water-Rich Modifiers: Enabling Separation of Peptides and Highly Polar Pharmaceuticals at the Preparative Scale

Authors: Liu, Jinchu, Makarov, Alexey A., Bennett, Raffeal, Ahmad, Imad A. Haidar, DaSilva, Jimmy, Reibarkh, Mikhail, Mangion, Ian, Mann, Benjamin F., Regalado, Erik L.

Source: Analytical chemistry. 91(21):13907-13915

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Generic Ion Chromatography—Conductivity Detection Method for Analysis of Palladium Scavengers in New Drug Substances

Authors: Zou, Lanfang, Bennett, Raffeal, Ahmad, Imad A. Haidar, Jocher, Brandon M., Zhang, Li, Bu, Xiaodong, Mangion, Ian, Regalado, Erik L.

Source: Organic process research & development. 23(5):1060-1068

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The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug Substances

Authors: Regalado, Erik L., Ahmad, Imad A. Haidar, Bennett, Raffeal, D Atri, Valentina, Makarov, Alexey A., Humphrey, Guy R., Mangion, Ian, Guillarme, Davy

Source: Accounts of chemical research. 52(7):1990-2002

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Nonlinear Predictive Modelling Enables In Silico Optimization of Chromatographic Methods for Complex Stationary Phase-Analyte Interactions.

Authors: Ahmad, Imad A. Haidar¹, Losacco, Gioacchino Luca¹, Clarke, Adrian², Regalado, Erik L.¹

Source: LC-GC Europe. Jul/Aug2022, Vol. 35 Issue 7, p273-278. 6p.

Subject Terms: *SMALL molecules, *PREDICTION models, *LIQUID chromatography, *RF values (Chromatography), *REGRESSION analysis, *ARTIFICIAL membranes

Trapping‐Enrichment Multi‐dimensional Liquid Chromatography with On‐Line Deuterated Solvent Exchange for Streamlined Structure Elucidation at the Microgram Scale

Authors: Ahmad, Imad A. Haidar, Losacco, Gioacchino Luca, Shchurik, Vladimir, Wang, Xiao, Cohen, Ryan D., Herron, Alastair N., Aiken, Sheenagh, Fiorito, Daniele, Wang, Heather, Reibarkh, Mikhail, Nowak, Timothy, Makarov, Alexey A., Stoll, Dwight R., Guillarme, Davy, Mangion, Ian, Aggarwal, Varinder K., Yu, Jin‐Quan, Regalado, Erik L.

Source: Angewandte Chemie. 134(21)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168209298.0x000001&indx=1&recIds=ETOCvdc_100168209298.0x000001

Dual‐Gradient Unified Chromatography: A New Paradigm for Versatility in Simultaneous Multicomponent Analysis

Authors: Losacco, Gioacchino Luca, Bennett, Raffeal, Ahmad, Imad A. Haidar, Barrientos, Rodell C., DaSilva, Jimmy O., Dong, Yuyang, Schuppe, Alexander W., Wang, Zeshu, Aiken, Sheenagh, Mangion, Ian, Aggarwal, Varinder K., Regalado, Erik L.

Source: Angewandte Chemie. 134(45)

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Front Cover: Generic reversed‐phase ultra‐high‐pressure liquid chromatography methodology developed by using computer‐assisted modeling for streamlined performance evaluation of a wide range of stationary phase columns

Authors: Ahmad, Imad A. Haidar, Losacco, Gioacchino Luca, Figus, Margaret, Korani, Deepa, Gunsch, Matthew J., Lhotka, Hayley R., Hullen, Kari, Hartman, Robert, Lohani, Sachin, Hamilton, Simon, Mangion, Ian, Regalado, Erik L.

Source: Separation science plus. 5(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150367778.0x000001&indx=1&recIds=ETOCvdc_100150367778.0x000001

Two-Dimensional Liquid Chromatography (2D-LC) in Pharmaceutical Analysis: Applications Beyond Increasing Peak Capacity

Authors: Ahmad, Imad A. Haidar, Blasko, Andrei, Clarke, Adrian, Fakih, Shereen

Source: Chromatographia. 81(3):401-418

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Cleaning verification: A five parameter study of a Total Organic Carbon method development and validation for the cleaning assessment of residual detergents in manufacturing equipment

Authors: Li, Xue, Ahmad, Imad A. Haidar, Tam, James, Wang, Yan, Dao, Gina, Blasko, Andrei

Source: Journal of pharmaceutical and biomedical analysis. 149:33-39

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A four parameter optimization and troubleshooting of a RPLC – charged aerosol detection stability indicating method for determination of S-lysophosphatidylcholines in a phospholipid formulation

Authors: Tam, James, Ahmad, Imad A. Haidar, Blasko, Andrei

Source: Journal of pharmaceutical and biomedical analysis. 155:288-297

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100058564477.0x000001&indx=1&recIds=ETOCvdc_100058564477.0x000001