Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

Authors: Tong, Xinyuan, Patel, Ayushi S., Kim, Eejung, Li, Hongjun, Chen, Yueqing, Li, Shuai, Liu, Shengwu, Dilly, Julien, Kapner, Kevin S., Zhang, Ningxia, Xue, Yun, Hover, Laura, Mukhopadhyay, Suman, Sherman, Fiona, Myndzar, Khrystyna, Sahu, Priyanka, Gao, Yijun, Li, Fei, Li, Fuming, Fang, Zhaoyuan, Jin, Yujuan, Gao, Juntao, Shi, Minglei, Sinha, Satrajit, Chen, Luonan, Chen, Yang, Kheoh, Thian, Yang, Wenjing, Yanai, Itai, Moreira, Andre L., Velcheti, Vamsidhar, Neel, Benjamin G., Hu, Liang, Christensen, James G., Olson, Peter, Gao, Dong, Zhang, Michael Q., Aguirre, Andrew J., Wong, Kwok-Kin, Ji, Hongbin

Source: In Cancer Cell 11 March 2024 42(3):413-428

Transforming Growth Factor-β Blockade in Pancreatic Cancer Enhances Sensitivity to Combination Chemotherapy

Authors: Qiang, Li, Hoffman, Megan T., Ali, Lestat R., Castillo, Jaime I., Kageler, Lauren, Temesgen, Ayantu, Lenehan, Patrick, Wang, S. Jennifer, Bello, Elisa, Cardot-Ruffino, Victoire, Uribe, Giselle A., Yang, Annan, Dougan, Michael, Aguirre, Andrew J., Raghavan, Srivatsan, Pelletier, Marc, Cremasco, Viviana, Dougan, Stephanie K.

Source: In Gastroenterology October 2023 165(4):874-890

Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities

Authors: Shi, Diana D ^*, Guo, Jimmy A ^*, Hoffman, Hannah I, Su, Jennifer, Mino-Kenudson, Mari, Barth, Jaimie L, Schenkel, Jason M, Loeffler, Jay S, Shih, Helen A, Hong, Theodore S, Wo, Jennifer Y, Aguirre, Andrew J, Jacks, Tyler, Zheng, Lei, Wen, Patrick Y, Wang, Timothy C, Hwang, William L ^*

Source: In The Lancet Oncology February 2022 23(2):e62-e74

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

Authors: Chen, Bob, Scurrah, Cherie’ R., McKinley, Eliot T., Simmons, Alan J., Ramirez-Solano, Marisol A., Zhu, Xiangzhu, Markham, Nicholas O., Heiser, Cody N., Vega, Paige N., Rolong, Andrea, Kim, Hyeyon, Sheng, Quanhu, Drewes, Julia L., Zhou, Yuan, Southard-Smith, Austin N., Xu, Yanwen, Ro, James, Jones, Angela L., Revetta, Frank, Berry, Lynne D., Niitsu, Hiroaki, Islam, Mirazul, Pelka, Karin, Hofree, Matan, Chen, Jonathan H., Sarkizova, Siranush, Ng, Kimmie, Giannakis, Marios, Boland, Genevieve M., Aguirre, Andrew J., Anderson, Ana C., Rozenblatt-Rosen, Orit, Regev, Aviv, Hacohen, Nir, Kawasaki, Kenta, Sato, Toshiro, Goettel, Jeremy A., Grady, William M., Zheng, Wei, Washington, M. Kay, Cai, Qiuyin, Sears, Cynthia L., Goldenring, James R., Franklin, Jeffrey L., Su, Timothy, Huh, Won Jae, Vandekar, Simon, Roland, Joseph T., Liu, Qi, Coffey, Robert J., Shrubsole, Martha J., Lau, Ken S.

Source: In Cell 22 December 2021 184(26):6262-6280

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Authors: Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

Source: In Cell 9 December 2021 184(25):6119-6137

Molecular basis for substrate recruitment to the PRMT5 methylosome

Authors: Mulvaney, Kathleen M., Blomquist, Christa, Acharya, Nischal, Li, Ruitong, Ranaghan, Matthew J., O’Keefe, Meghan, Rodriguez, Diego J., Young, Michael J., Kesar, Devishi, Pal, Debjani, Stokes, Matthew, Nelson, Alissa J., Jain, Sidharth S., Yang, Annan, Mullin-Bernstein, Zachary, Columbus, Josie, Bozal, Fazli K., Skepner, Adam, Raymond, Donald, LaRussa, Salvatore, McKinney, David C., Freyzon, Yelena, Baidi, Yossef, Porter, Dale, Aguirre, Andrew J., Ianari, Alessandra, McMillan, Brian, Sellers, William R.

Source: In Molecular Cell 2 September 2021 81(17):3481-3495

Spatially organized multicellular immune hubs in human colorectal cancer

Authors: Pelka, Karin, Hofree, Matan, Chen, Jonathan H., Sarkizova, Siranush, Pirl, Joshua D., Jorgji, Vjola, Bejnood, Alborz, Dionne, Danielle, Ge, William H., Xu, Katherine H., Chao, Sherry X., Zollinger, Daniel R., Lieb, David J., Reeves, Jason W., Fuhrman, Christopher A., Hoang, Margaret L., Delorey, Toni, Nguyen, Lan T., Waldman, Julia, Klapholz, Max, Wakiro, Isaac, Cohen, Ofir, Albers, Julian, Smillie, Christopher S., Cuoco, Michael S., Wu, Jingyi, Su, Mei-ju, Yeung, Jason, Vijaykumar, Brinda, Magnuson, Angela M., Asinovski, Natasha, Moll, Tabea, Goder-Reiser, Max N., Applebaum, Anise S., Brais, Lauren K., DelloStritto, Laura K., Denning, Sarah L., Phillips, Susannah T., Hill, Emma K., Meehan, Julia K., Frederick, Dennie T., Sharova, Tatyana, Kanodia, Abhay, Todres, Ellen Z., Jané-Valbuena, Judit, Biton, Moshe, Izar, Benjamin, Lambden, Conner D., Clancy, Thomas E., Bleday, Ronald, Melnitchouk, Nelya, Irani, Jennifer, Kunitake, Hiroko, Berger, David L., Srivastava, Amitabh, Hornick, Jason L., Ogino, Shuji, Rotem, Asaf, Vigneau, Sébastien, Johnson, Bruce E., Corcoran, Ryan B., Sharpe, Arlene H., Kuchroo, Vijay K., Ng, Kimmie, Giannakis, Marios, Nieman, Linda T., Boland, Genevieve M., Aguirre, Andrew J., Anderson, Ana C., Rozenblatt-Rosen, Orit, Regev, Aviv, Hacohen, Nir

Source: In Cell 2 September 2021 184(18):4734-4752

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization

Authors: Dai, Chao, Rennhack, Jonathan P., Arnoff, Taylor E., Thaker, Maneesha, Younger, Scott T., Doench, John G., Huang, August Yue, Yang, Annan, Aguirre, Andrew J., Wang, Belinda, Mun, Evan, O’Connell, Joyce T., Huang, Ying, Labella, Katherine, Talamas, Jessica A., Li, Ji, Ilic, Nina, Hwang, Justin, Hong, Andrew L., Giacomelli, Andrew O., Gjoerup, Ole, Root, David E., Hahn, William C.

Source: In Cell Reports 27 July 2021 36(4)

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

Authors: Waters, Andrew M., Khatib, Tala O., Papke, Bjoern, Goodwin, Craig M., Hobbs, G. Aaron, Diehl, J. Nathaniel, Yang, Runying, Edwards, A. Cole, Walsh, Katherine H., Sulahian, Rita, McFarland, James M., Kapner, Kevin S., Gilbert, Thomas S.K., Stalnecker, Clint A., Javaid, Sehrish, Barkovskaya, Anna, Grover, Kajal R., Hibshman, Priya S., Blake, Devon R., Schaefer, Antje, Nowak, Katherine M., Klomp, Jennifer E., Hayes, Tikvah K., Kassner, Michelle, Tang, Nanyun, Tanaseichuk, Olga, Chen, Kaisheng, Zhou, Yingyao, Kalkat, Manpreet, Herring, Laura E., Graves, Lee M., Penn, Linda Z., Yin, Hongwei H., Aguirre, Andrew J., Hahn, William C., Cox, Adrienne D., Der, Channing J.

Source: In Cell Reports 29 June 2021 35(13)

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

Authors: Biancur, Douglas E., Kapner, Kevin S., Yamamoto, Keisuke, Banh, Robert S., Neggers, Jasper E., Sohn, Albert S.W., Wu, Warren, Manguso, Robert T., Brown, Adam, Root, David E., Aguirre, Andrew J., Kimmelman, Alec C.

Source: In Cell Metabolism 5 January 2021 33(1):199-210

The prognostic value of HER2 gene dosage and heterogeneity at a single-cell resolution in gastroesophageal adenocarcinoma.

Authors: Parashar, Yashika¹ (AUTHOR), Culnane, Leigh¹ (AUTHOR), Remland, Joshua¹ (AUTHOR), Nambiar, Chetan¹ (AUTHOR), Yuan, Chen² (AUTHOR), Nasta, Shagun¹ (AUTHOR), Bard, Adam³ (AUTHOR), Park, Haeseong¹ (AUTHOR), Klempner, Samuel J.³ (AUTHOR), Giannakis, Marios¹ (AUTHOR), Aguirre, Andrew¹ (AUTHOR), Ng, Kimmie¹ (AUTHOR), Meyerhardt, Jeffrey A.⁴ (AUTHOR), Wolpin, Brian M.⁵ (AUTHOR), Yaeger, Rona⁶ (AUTHOR), Cleary, James M.¹ (AUTHOR), Wang, Charlotte⁷ (AUTHOR), Enzinger, Peter C.¹ (AUTHOR), Sethi, Nilay S.¹ (AUTHOR), Singh, Harshabad⁸ (AUTHOR)

Source: Journal of Clinical Oncology. 2025 Supplement 4, Vol. 43, p473-473. 188p.

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

Authors: Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

Source: In Cell Reports 15 December 2020 33(11)

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

Authors: Drokhlyansky, Eugene, Smillie, Christopher S., Van Wittenberghe, Nicholas, Ericsson, Maria, Griffin, Gabriel K., Eraslan, Gokcen, Dionne, Danielle, Cuoco, Michael S., Goder-Reiser, Max N., Sharova, Tatyana, Kuksenko, Olena, Aguirre, Andrew J., Boland, Genevieve M., Graham, Daniel, Rozenblatt-Rosen, Orit, Xavier, Ramnik J., Regev, Aviv

Source: In Cell 17 September 2020 182(6):1606-1622

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

Authors: Escobar-Hoyos, Luisa F., Penson, Alex, Kannan, Ram, Cho, Hana, Pan, Chun-Hao, Singh, Rohit K., Apken, Lisa H., Hobbs, G. Aaron, Luo, Renhe, Lecomte, Nicolas, Babu, Sruthi, Pan, Fong Cheng, Alonso-Curbelo, Direna, Morris, John P., IV, Askan, Gokce, Grbovic-Huezo, Olivera, Ogrodowski, Paul, Bermeo, Jonathan, Saglimbeni, Joseph, Cruz, Cristian D., Ho, Yu-Jui, Lawrence, Sharon A., Melchor, Jerry P., Goda, Grant A., Bai, Karen, Pastore, Alessandro, Hogg, Simon J., Raghavan, Srivatsan, Bailey, Peter, Chang, David K., Biankin, Andrew, Shroyer, Kenneth R., Wolpin, Brian M., Aguirre, Andrew J., Ventura, Andrea, Taylor, Barry, Der, Channing J., Dominguez, Daniel, Kümmel, Daniel, Oeckinghaus, Andrea, Lowe, Scott W., Bradley, Robert K., Abdel-Wahab, Omar, Leach, Steven D.

Source: In Cancer Cell 10 August 2020 38(2):198-211

Biomarker-Guided Development of DNA Repair Inhibitors

Authors: Cleary, James M., Aguirre, Andrew J., Shapiro, Geoffrey I., D’Andrea, Alan D.

Source: In Molecular Cell 18 June 2020 78(6):1070-1085

Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics

Authors: Santana-Codina, Naiara, Chandhoke, Amrita Singh, Yu, Qijia, Małachowska, Beata, Kuljanin, Miljan, Gikandi, Ajami, Stańczak, Marcin, Gableske, Sebastian, Jedrychowski, Mark P., Scott, David A., Aguirre, Andrew J., Fendler, Wojciech, Gray, Nathanael S., Mancias, Joseph D.

Source: In Cell Reports 31 March 2020 30(13):4584-4599

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

Authors: Sulahian, Rita, Kwon, Jason J., Walsh, Katherine H., Pailler, Emma, Bosse, Timothy L., Thaker, Maneesha, Almanza, Diego, Dempster, Joshua M., Pan, Joshua, Piccioni, Federica, Dumont, Nancy, Gonzalez, Alfredo, Rennhack, Jonathan, Nabet, Behnam, Bachman, John A., Goodale, Amy, Lee, Yenarae, Bagul, Mukta, Liao, Rosy, Navarro, Adrija, Yuan, Tina L., Ng, Raymond W.S., Raghavan, Srivatsan, Gray, Nathanael S., Tsherniak, Aviad, Vazquez, Francisca, Root, David E., Firestone, Ari J., Settleman, Jeff, Hahn, William C., Aguirre, Andrew J.

Source: In Cell Reports 1 October 2019 29(1):118-134

Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D

Authors: Johnson, Christian W., Lin, Yi-Jang, Reid, Derion, Parker, Jillian, Pavlopoulos, Spiro, Dischinger, Patrick, Graveel, Carrie, Aguirre, Andrew J., Steensma, Matthew, Haigis, Kevin M., Mattos, Carla

Source: In Cell Reports 6 August 2019 28(6):1538-1550

4 - KRAS-driven cancer models for in vivo pharmacology and drug discovery

Authors: Chugh, Seema, Dow, Lukas E., Singh, Mallika, Aguirre, Andrew J.

Source: In RAS Drug Discovery 2025:93-118

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

Authors: Yurgelun, Matthew B., Chittenden, Anu B., Morales-Oyarvide, Vicente, Rubinson, Douglas A., Dunne, Richard F., Kozak, Margaret M., Qian, Zhi Rong, Welch, Marisa W., Brais, Lauren K., Da Silva, Annacarolina, Bui, Justin L., Yuan, Chen, Li, Tingting, Li, Wanwan, Masuda, Atsuhiro, Gu, Mancang, Bullock, Andrea J., Chang, Daniel T., Clancy, Thomas E., Linehan, David C., Findeis-Hosey, Jennifer J., Doyle, Leona A., Thorner, Aaron R., Ducar, Matthew D., Wollison, Bruce M., Khalaf, Natalia, Perez, Kimberly, Syngal, Sapna, Aguirre, Andrew J., Hahn, William C., Meyerson, Matthew L., Fuchs, Charles S., Ogino, Shuji, Hornick, Jason L., Hezel, Aram F., Koong, Albert C., Nowak, Jonathan A., Wolpin, Brian M.

Source: In Genetics in Medicine January 2019 21(1):213-223