DNA damage response defects in hematologic malignancies: mechanistic insights and therapeutic strategies

Authors: Kwok, Marwan, Agathanggelou, Angelo, Stankovic, Tatjana

Source: In Blood 23 May 2024 143(21):2123-2144

TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target

Authors: Kennedy, Emma ^*, Coulter, Eve ^*, Halliwell, Emma, Profitos-Peleja, Nuria, Walsby, Elisabeth, Clark, Barnaby, Phillips, Elizabeth H., Burley, Thomas A., Mitchell, Simon, Devereux, Stephen, Fegan, Christopher D., Jones, Christopher I., Johnston, Rosalynd, Chevassut, Tim, Schulz, Ralph, Seiffert, Martina, Agathanggelou, Angelo, Oldreive, Ceri, Davies, Nicholas, Stankovic, Tatjana, Liloglou, Triantafillos, Pepper, Chris, Pepper, Andrea G.S. ^*

Source: In Blood 3 June 2021 137(22):3064-3078

Aniline-containing derivatives of parthenolide: Synthesis and anti-chronic lymphocytic leukaemia activity

Authors: Quy, Alex S., Li, Xingjian, Male, Louise, Stankovic, Tatjana, Agathanggelou, Angelo, Fossey, John S.

Source: In Tetrahedron 27 November 2020 76(48)

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL

Authors: Kwok, Marwan ^{1, 1, 2, 3, *}, Oldreive, Ceri ^{1, *}, Rawstron, Andy C. ³, Goel, Anshita ^{1, 4}, Papatzikas, Grigorios ^{1, 4}, Jones, Rhiannon E. ⁵, Drennan, Samantha ⁶, Agathanggelou, Angelo ¹, Sharma-Oates, Archana ^{1, 4}, Evans, Paul ³, Smith, Edward ¹, Dalal, Surita ³, Mao, Jingwen ¹, Hollows, Robert ¹, Gordon, Naheema ¹, Hamada, Mayumi ¹, Davies, Nicholas J. ¹, Parry, Helen ^{2, 7}, Beggs, Andrew D. ¹, Munir, Talha ³, Moreton, Paul ⁸, Paneesha, Shankara ⁹, Pratt, Guy ^{1, 2}, Taylor, A. Malcolm R. ¹, Forconi, Francesco ⁶, Baird, Duncan M. ⁵, Cazier, Jean-Baptiste ^{1, 4}, Moss, Paul ^{2, 7}, Hillmen, Peter ^{3, 10}, Stankovic, Tatjana ^{2, 1, †}

Source: In Blood 6 February 2020 135(6):411-428

Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemiaElectronic supplementary information (ESI) available: General experimental details, aspects relating to cultivation of feverfew, the PTL extraction protocol, synthesis, biological assays computational information and spectrums are detailed in the supporting information. Methods described and references cited therein, 45 should be referred to in regard of the docking, crystallographic, synthetic and toxicological studies detailed therein. See DOI: 10.1039/c9md00297a

Authors: LiAA and JSF are joint last and co-corresponding authors, XL and DTP share joint first authorship. Remaining authors are listed alphabetically, author contributions are described later., Xingjian, Payne, Daniel T., AmpoluPresent address: BioMedha Limited, Biocity, Innovation Building, Pennyfoot Street, Nottingham NG1 1GF, UK., Badarinath, BlandPresent address: Excellerate Bioscience Limited, Discovery Building, Biocity, Pennyfoot Street, Nottingham, NG1 IGR, UK., Nicholas, Brown, Jane T., Dutton, Mark J., Fitton, Catherine A., Gulliver, Abigail, Hale, Lee, Hamza, Daniel, Jones, Geraint, Lane, Rebecca, Leach, Andrew G., Male, Louise, Merisor, Elena G., Morton, Michael J., Quy, Alex S., Roberts, Ruth, Scarll, Rosanna, Schulz-Utermoehl, Timothy, Stankovic, Tatjana, Stevenson, Brett, Fossey, John S., Agathanggelou, Angelo

Source: MedChemComm. 10(8):1379-1390

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100086649226.0x000001&indx=1&recIds=ETOCvdc_100086649226.0x000001

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

Authors: Agathanggelou, Angelo, Smith, Edward ^*, Davies, Nicholas J., Kwok, Marwan, Zlatanou, Anastasia, Oldreive, Ceri E., Mao, Jingwen, Da Costa, David, Yadollahi, Sina, Perry, Tracey, Kearns, Pamela, Skowronska, Anna, Yates, Elliot, Parry, Helen, Hillmen, Peter, Reverdy, Celine, Delansorne, Remi, Paneesha, Shankara, Pratt, Guy, Moss, Paul, Taylor, A.Malcolm R., Stewart, Grant S., Stankovic, Tatjana

Source: In Blood 13 July 2017 130(2):156-166

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Authors: Zimmermann, Michal, Murina, Olga, Reijns, Martin, Agathanggelou, Angelo, Challis, Rachel, Tarnauskaitė, Žygimantė, Muir, Morwenna, Fluteau, Adeline, Aregger, Michael, McEwan, Andrea, Yuan, Wei, Clarke, Matthew, Lambros, Maryou, Paneesha, Shankara, Moss, Paul, Chandrashekhar, Megha, Angers, Stephane, Moffat, Jason, Brunton, Valerie, Hart, Traver, Bono, Johann, Stankovic, Tatjana, Jackson, Andrew, Durocher, Daniel

Source: Nature. 559(7713):285-289

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171353587.0x000001&indx=1&recIds=ETOCvdc_100171353587.0x000001

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells

Authors: Kwok, Marwan ^*, Davies, Nicholas ^*, Agathanggelou, Angelo, Smith, Edward, Oldreive, Ceri, Petermann, Eva, Stewart, Grant, Brown, Jeff, Lau, Alan, Pratt, Guy, Parry, Helen, Taylor, Malcolm, Moss, Paul, Hillmen, Peter, Stankovic, Tatjana ^*

Source: In Blood 4 February 2016 127(5):582-595

Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Authors: Agathanggelou, Angelo

Source: Haematologica. 100(8):1076-1085

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN602826520&indx=1&recIds=ETOCRN602826520

Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia

Authors: Goodyear, Oliver ^*, Agathanggelou, Angelo ^*, Novitzky-Basso, Igor, Siddique, Shamyla, McSkeane, Tina, Ryan, Gordon, Vyas, Paresh, Cavenagh, Jamie, Stankovic, Tanja, Moss, Paul, Craddock, Charles ^*

Source: In Blood 16 September 2010 116(11):1908-1918

Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response

Authors: Marston, Eliot, Weston, Victoria, Jesson, Jennifer, Maina, Esther, McConville, Carmel, Agathanggelou, Angelo, Skowronska, Anna, Mapp, Katie, Sameith, Katrin, Powell, Judith E., Lawson, Sarah, Kearns, Pamela, Falciani, Francesco, Taylor, Malcolm, Stankovic, Tatjana ^*

Source: In Blood 1 January 2009 113(1):117-126

Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers.

Authors: Agathanggelou, Angelo, Dallol, Ashraf, Zochbauer-Muller, Sabine, Morrissey, Catherine, Honorio, Sofia, Hesson, Luke, Martinsson, Tommy, Fong, Kwun M, Kuo, Michael J, Yuen, Po Wing, Maher, Eamonn R, Minna, John D, Latif, Farida

Source: Oncogene. 3/13/2003, Vol. 22 Issue 10, p1580. 9p.

Subject Terms: *TUMOR suppressor genes, *CANCER, *CARCINOGENESIS

Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumours.

Authors: Honorio, Sofia, Agathanggelou, Angelo, Wernert, Nicolas, Rothe, Marcus, Maher, Eamonn R, Latif, Farida

Source: Oncogene. 1/23/2003, Vol. 22 Issue 3, p461. 6p.

Subject Terms: *GERM cells, *TUMORS, *TUMOR suppressor genes

Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients.

Authors: Honorio, Sofia, Agathanggelou, Angelo, Schuermann, Marcus, Pankow, Wulf, Viacava, Paolo, Maher, Eamonn R, Latif, Farida

Source: Oncogene. 1/9/2003, Vol. 22 Issue 1, p147. 4p.

Subject Terms: *LUNG tumors, *SMOKING, *BREAST tumors, *CANCER

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RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours.

Authors: Astuti, Dewi, Agathanggelou, Angelo, Honorio, Sofia, Dallol, Ashraf, Martinsson, Tommy, Kogner, Per, Cummins, Carole, Neumann, Hartmut PH, Voutilainen, Raimo, Dahia, Patricia, Eng, Charis, Maher, Eamonn R, Latif, Farida

Source: Oncogene. 11/8/2001, Vol. 20 Issue 51, p7573. 5p.

Subject Terms: *CHROMOSOMES, *NEUROBLASTOMA, *TUMORS, *TUMOR suppressor genes

Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours.

Authors: Agathanggelou, Angelo, Honorio, Sofia, Macartney, Donia P, Martinez, Alonso, Dallol, Ashraf, Rader, Janet, Fullwood, Paul, Chauhan, Anita, Walker, Rosemary, Shaw, Jacqueline A, Hosoe, Shigeto, Lerman, Michael I, Minna, John D, Maher, Eamonn R, Latif, Farida

Source: Oncogene. 3/22/2001, Vol. 20 Issue 12, p1509. 10p.

Subject Terms: *TUMORS, *LUNG tumors, *OVARIAN tumors, *BREAST tumors, *TUMOR suppressor genes

Inhibition of Human Breast Carcinoma Growth by a Soluble Recombinant Human CD40 Ligand

Authors: Hirano, Akio, Longo, Dan L., Taub, Dennis D., Ferris, Douglas K., Young, Lawrence S., Eliopoulos, Arisitides G., Agathanggelou, Angelo, Cullen, Nicky, Macartney, James, Fanslow, William C., Murphy, William J. ^*

Source: In Blood 1 May 1999 93(9):2999-3007

Correction: Kwok et al. Targeting the p53 Pathway in CLL: State of the Art and Future Perspectives. Cancers 2021, 13 , 4681.

Authors: Kwok, Marwan^1,2 (AUTHOR) a.agathanggelou@bham.ac.uk, Agathanggelou, Angelo¹ (AUTHOR) n.j.davies@bham.ac.uk, Davies, Nicholas¹ (AUTHOR), Stankovic, Tatjana¹ (AUTHOR) m.kwok@bham.ac.uk

Source: Cancers. Feb2022, Vol. 14 Issue 2, p321-321. 1p.

Subject Terms: *PROTEIN metabolism, *CHRONIC lymphocytic leukemia, *ONCOGENES, *CELLULAR signal transduction, *DNA damage

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