Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma

Authors: Watanabe, Keisuke, Gomez, Angela M., Kuramitsu, Shunichiro, Siurala, Mikko, Da, Tong, Agarwal, Sangya, Song, Decheng, Scholler, John, Rotolo, Antonia, Posey, Avery D., Jr., Rook, Alain H., Haun, Paul L., Ruella, Marco, Young, Regina M., June, Carl H.

Source: In Blood Advances 25 July 2023 7(14):3416-3430

Better living through chemistry: CRISPR/Cas engineered T cells for cancer immunotherapy

Authors: Wellhausen, Nils, Agarwal, Sangya, Rommel, Philipp C, Gill, Saar I, June, Carl H

Source: Current opinion in immunology. 74:76-84

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157378535.0x000001&indx=1&recIds=ETOCvdc_100157378535.0x000001

An NK-like CAR T cell transition in CAR T cell dysfunction

Authors: Good, Charly R., Aznar, M. Angela, Kuramitsu, Shunichiro, Samareh, Parisa, Agarwal, Sangya, Donahue, Greg, Ishiyama, Kenichi, Wellhausen, Nils, Rennels, Austin K., Ma, Yujie, Tian, Lifeng, Guedan, Sonia, Alexander, Katherine A., Zhang, Zhen, Rommel, Philipp C., Singh, Nathan, Glastad, Karl M., Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O’Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

Source: In Cell 9 December 2021 184(25):6081-6100

Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice

Authors: Wang, Yang, Esquivel, Rianne, Flingai, Seleeke, Schiller, Zachary A., Kern, Aurélie, Agarwal, Sangya, Chu, Jacqueline, Patel, Ami, Sullivan, Katherine, Wise, Megan C., Broderick, Kate E., Hu, Linden, Weiner, David B., Klempner, Mark S.

Source: The Journal of Infectious Diseases, 2019 Apr 01. 219(7), 1146-1150.

Access URL: https://www.jstor.org/stable/26749018

Synthetic nucleic acid antibody prophylaxis confers rapid and durable protective immunity against Zika virus challenge

Authors: Choi, Hyeree, Kudchodkar, Sagar B., Reuschel, Emma L., Asija, Kanika, Borole, Piyush, Agarwal, Sangya, Van Gorder, Lucas, Reed, Charles C., Gulendran, Gayathri, Ramos, Stephanie, Broderick, Kate E., Kim, J Joseph, Ugen, Kenneth E., Kobinger, Gary, Siegel, Don L., Weiner, David B., Muthumani, Kar

Source: Human vaccines & immunotherapeutics. 16(4):907-918

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127328368.0x000001&indx=1&recIds=ETOCvdc_100127328368.0x000001

Epitope Editing in Hematopoietic Cells Enables CD45-Directed Immune Therapy

Authors: Wellhausen, Nils, Rennels, Austin K ^*, Lesch, Stefanie ^*, Agarwal, Sangya ^*, Charria, Brooke ^*, Choi, Grace ^*, Young, Regina M ^*, Garcia, Christopher ^*, June, Carl H, Gill, Saar

Source: In Blood 15 November 2022 140 Supplement 1:862-864

Potentiating adoptive cell therapy using synthetic IL-9 receptors.

Authors: Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J.

Source: Nature; Jul2022, Vol. 607 Issue 7918, p360-365, 6p

LFA-1 signals to promote actin polymerization and upstream migration in T cells.

Authors: Roy, Nathan H., Ji Kim, Sarah Hyun, Jr., Alexander Buffone, Blumenthal, Daniel, Huang, Bonnie, Agarwal, Sangya, Schwartzberg, Pamela L., Hammer, Daniel A., Burkhardt, Janis K.

Source: Journal of Cell Science; 2020, Vol. 133 Issue 17, p1-10, 10p

Subject Terms: T cells, CELL migration, PHOSPHATIDYLINOSITOL 3-kinases, SHEAR flow, CELL morphology, UBIQUITINATION, SPREADING cortical depression

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Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells.

Authors: Agarwal, Sangya^1,2 (AUTHOR), Aznar, M. Angela¹ (AUTHOR), Rech, Andrew J.^1,2 (AUTHOR), Good, Charly R.³ (AUTHOR), Kuramitsu, Shunichiro¹ (AUTHOR), Da, Tong¹ (AUTHOR), Gohil, Mercy¹ (AUTHOR), Chen, Linhui⁴ (AUTHOR), Hong, Seok-Jae Albert¹ (AUTHOR), Ravikumar, Pranali¹ (AUTHOR), Rennels, Austin K.¹ (AUTHOR), Salas-Mckee, January¹ (AUTHOR), Kong, Weimin^1,5 (AUTHOR), Ruella, Marco^1,6,7,8,9 (AUTHOR), Davis, Megan M.^1,5 (AUTHOR), Plesa, Gabriela¹ (AUTHOR), Fraietta, Joseph A.^1,5,6 (AUTHOR), Porter, David L.⁷ (AUTHOR), Young, Regina M.^1,2,6 (AUTHOR) ryoung@upenn.edu, June, Carl H.^1,2,6,9 (AUTHOR) cjune@upenn.edu

Source: Immunity (10747613). Oct2023, Vol. 56 Issue 10, p2388-2388. 1p.

Subject Terms: *CHIMERIC antigen receptors, *CHRONIC leukemia, *B cell lymphoma, *CYTOTOXIC T lymphocyte-associated molecule-4, *CHRONIC lymphocytic leukemia, *T cells

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Publisher Correction: Potentiating adoptive cell therapy using synthetic IL-9 receptors.

Authors: Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J.

Source: Nature; Dec2022, Vol. 612 Issue 7938, pE10-E10, 1p

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