Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis

Authors: MacDonald, Lucy ^{1, 2, 16}, Elmesmari, Aziza ^{1, 2, 16}, Somma, Domenico ^{1, 2, 16}, Frew, Jack ^{1, 2, 16}, Di Mario, Clara ³, Madhu, Roopa ^{4, 5, 6}, Paoletti, Audrey ², Simakou, Theodoros ^{1, 2}, Hardy, Olympia M. ^{1, 2}, Tolusso, Barbara ³, Campobasso, Denise ³, Perniola, Simone ^{3, 7}, Gessi, Marco ⁸, Gigante, Maria Rita ⁹, Petricca, Luca ⁹, Bruno, Dario ^{1, 3, 7}, Coletto, Lavinia Agra ^{1, 2, 3}, Benvenuto, Roberta ⁸, Isaacs, John D. ^{1, 10, 11}, Filby, Andrew ¹², McDonald, David ¹², Sim, Jasmine P.X. ^{1, 10}, Jamieson, Nigel ¹³, Wei, Kevin ⁴, D’Agostino, Maria Antonietta ⁹, Millar, Neal L. ^{1, 2}, Milling, Simon ^{1, 2}, McSharry, Charles ^{2, 14}, Gremese, Elisa ^{1, 3, 7}, Affleck, Karen ¹⁵, Baker, Kenneth F. ^{1, 10, 11}, McInnes, Iain B. ^{1, 2}, Otto, Thomas D. ^{1, 2}, Korsunsky, Ilya ^{4, 5, 6}, Alivernini, Stefano ^{1, 2, 3, 9, 16, ∗}, Kurowska-Stolarska, Mariola ^{1, 2, 16, 17, ∗∗}

Source: In Immunity 10 December 2024 57(12):2843-2862

Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue

Authors: Perez-Novo Claudina, Gevaert Philippe, Affleck Karen, Holtappels Gabriele, Patou Joke, Van Cauwenberge Paul, Bachert Claus

Source: Journal of Inflammation, Vol 6, Iss 1, p 11 (2009)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.journal-inflammation.com/content/6/1/11; https://doaj.org/toc/1476-9255

Access URL: https://doaj.org/article/f094ae11792648c78af614c3249c27d7

IL1RAP expression and the enrichment of IL‐33 activation signatures in severe neutrophilic asthma

Authors: Badi, Yusef Eamon, Salcman, Barbora, Taylor, Adam, Rana, Batika, Kermani, Nazanin Zounemat, Riley, John H., Worsley, Sally, Mumby, Sharon, Dahlen, Sven‐Eric, Cousins, David, Bulfone‐Paus, Silvia, Affleck, Karen, Chung, Kian Fan, Bates, Stewart, Adcock, Ian M.

Source: Allergy. 78(1):156-167

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171075574.0x000001&indx=1&recIds=ETOCvdc_100171075574.0x000001

Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation.

Authors: Portelli, Michael A., Ketelaar, Maria E., Bates, Stewart, Csomor, Eszter, Shaw, Dominick, Emsley, Jonas, Brightling, Christopher, Hall, Ian, Affleck, Karen, Edwards, Matthew, Nawijn, Martijn C., Koppelman, Gerard H., Van Oosterhout, Antoon J., Sayers, Ian

Source: Clinical & Experimental Allergy; Dec2024, Vol. 54 Issue 12, p984-995, 12p

Subject Terms: ASTHMATICS, GENETIC variation, INTERLEUKIN receptors, GENE expression, HAPLOTYPES

The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors

Authors: Deaton, David N., Do, Young, Holt, Jason, Jeune, Michael R., Kramer, H. Fritz, Larkin, Andrew L., Orband-Miller, Lisa A., Peckham, Gregory E., Poole, Chuck, Price, Daniel J., Schaller, Lee T., Shen, Ying, Shewchuk, Lisa M., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tianshun, Guss, Jeffrey H., Musetti, Caterina, Rendina, Alan R., Affleck, Karen, Anders, David, Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Hutchinson, Jonathan, Leveridge, Melanie V., Nicholls, Harry, Smith, Ian E.D., Somers, Don O., Sneddon, Helen F., Uddin, Sorif, Cleasby, Anne, Mortenson, Paul N., Richardson, Caroline, Saxty, Gordon

Source: In Bioorganic & Medicinal Chemistry 15 April 2019 27(8):1456-1478

A cellular census of human lungs identifies novel cell states in health and in asthma

Authors: Vieira Braga, Felipe, Kar, Gozde, Berg, Marijn, Carpaij, Orestes, Polanski, Krzysztof, Simon, Lukas, Brouwer, Sharon, Gomes, Tomás, Hesse, Laura, Jiang, Jian, Fasouli, Eirini, Efremova, Mirjana, Vento-Tormo, Roser, Talavera-López, Carlos, Jonker, Marnix, Affleck, Karen, Palit, Subarna, Strzelecka, Paulina, Firth, Helen, Mahbubani, Krishnaa, Cvejic, Ana, Meyer, Kerstin, Saeb-Parsy, Kourosh, Luinge, Marjan, Brandsma, Corry-Anke, Timens, Wim, Angelidis, Ilias, Strunz, Maximilian, Koppelman, Gerard, Oosterhout, Antoon, Schiller, Herbert, Theis, Fabian, Berge, Maarten, Nawijn, Martijn, Teichmann, Sarah

Source: Nature medicine. 25(7):1153-1163

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184287437.0x000001&indx=1&recIds=ETOCvdc_100184287437.0x000001

P2X7 Receptor-Induced Human Mast Cell Degranulation Is Enhanced by Interleukin 33.

Authors: Salcman, Barbora, Bahri, Rajia, West, Peter W., Tontini, Chiara, Affleck, Karen, Bulfone-Paus, Silvia

Source: International Journal of Molecular Sciences; Feb2024, Vol. 25 Issue 3, p1730, 17p

Subject Terms: MAST cells, PURINERGIC receptors, INTERLEUKIN-33, ADENOSINE triphosphate, THYMIC stromal lymphopoietin, SOFT tissue injuries

Lack of a transcriptional response of primary bronchial epithelial cells from patients with asthma and controls to IL-33.

Authors: Saikumar Jayalatha, Akshaya Keerthi, Jonker, Marnix R., Carpaij, Orestes A., van den Berge, Maarten, Affleck, Karen X., Koppelman, Gerard H., Nawijn, Martijn C.

Source: American Journal of Physiology: Lung Cellular & Molecular Physiology; Jan2024, Vol. 326 Issue 1, pL65-L70, 6p

Subject Terms: EPITHELIAL cells, INTERLEUKIN-33, ASTHMATICS, EPITHELIAL cell culture, INNATE lymphoid cells, ADRENERGIC beta agonists

Regulatory T-cell–intrinsic amphiregulin is dispensable for suppressive function

Authors: Carney, Katharine, Chang, Yu-Mei (Ruby), Wilson, Stephen, Calnan, Clare, Reddy, Pala S., Chan, Win-Yan, Gilmartin, Timothy, Hernandez, Gilberto, Schaffer, Lana, Head, Steven R., Morley, Joanne, de Mestre, Amanda, Affleck, Karen, Garden, Oliver A.

Source: Journal of allergy and clinical immunology. 137(6):1907-1909

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100066176908.0x000001&indx=1&recIds=ETOCvdc_100066176908.0x000001

Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma

Authors: Vasavda, Nisha, Eichholtz, Thomas, Takahashi, Atsushi, Affleck, Karen, Matthews, John G., Barnes, Peter J., Adcock, Ian M.

Source: In The Journal of Allergy and Clinical Immunology 2006 118(5):1090-1096

hCLCA1 and mCLCA3 Are Secreted Non-integral Membrane Proteins and Therefore Are Not Ion Channels

Authors: Gibson, Adele, Lewis, Alan P., Affleck, Karen ^‡, Aitken, Alan J., Meldrum, Eric, Thompson, Nicola

Source: In Journal of Biological Chemistry 22 July 2005 280(29):27205-27212

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P2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation.

Authors: Salcman, Barbora¹ (AUTHOR) barbora.salcman@postgrad.manchester.ac.uk, Affleck, Karen² (AUTHOR) karen.x.affleck@gsk.com, Bulfone-Paus, Silvia¹ (AUTHOR) silvia.bulfone-paus@manchester.ac.uk

Source: Cells (2073-4409). Sep2021, Vol. 10 Issue 9, p2282. 1p.

Subject Terms: *MAST cells, *NEUROINFLAMMATION, *NEUROGLIA, *ASTROCYTES, *MICROGLIA, *NEURONS, *OLIGODENDROGLIA

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Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue.

Authors: Patou, Joke, Holtappels, Gabriele, Affleck, Karen, Gevaert, Philippe, Perez-Novo, Claudina, Van Cauwenberge, Paul, Bachert, Claus

Source: Journal of Inflammation; 2009, Vol. 6, p1-10, 10p, 1 Color Photograph, 2 Charts, 2 Graphs

Subject Terms: ALLERGIC rhinitis, NASAL polyps, IMMUNOGLOBULIN E, MAST cells, HISTAMINE

Discovery and Biological Evaluation of Potent Dual ErbB-2/EGFR Tyrosine Kinase Inhibitors: 6-Thiazolylquinazolines

Authors: Gaul, Micheal D, Guo, Yu, Affleck, Karen, Cockerill, G.Stuart, Gilmer, Tona M, Griffin, Robert J, Guntrip, Stephen, Keith, Barry R, Knight, Wilson B, Mullin, Robert J, Murray, Doris M, Rusnak, David W, Smith, Kathryn, Tadepalli, Sarva, Wood, Edgar R, Lackey, Karen

Source: In Bioorganic & Medicinal Chemistry Letters 2003 13(4):637-640