HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes

Authors: Natasha Hui Jin Ng, Soumita Ghosh, Chek Mei Bok, Carmen Ching, Blaise Su Jun Low, Juin Ting Chen, Euodia Lim, María Clara Miserendino, Yaw Sing Tan, Shawn Hoon, Adrian Kee Keong Teo

Source: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4aec6ae44ee44ca4ad13b73cb8abffaf

Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation

Authors: Beatrice Xuan Ho, Adrian Kee Keong Teo, Natasha Hui Jin Ng

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: stem cells, regenerative medicine, diabetes, islet cells, beta cells, islet transplantation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375177/full; https://doaj.org/toc/1664-3224

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PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development

Authors: Hwee Hui Lau, Nicole A. J. Krentz, Fernando Abaitua, Marta Perez-Alcantara, Jun-Wei Chan, Jila Ajeian, Soumita Ghosh, Yunkyeong Lee, Jing Yang, Swaraj Thaman, Benoite Champon, Han Sun, Alokkumar Jha, Shawn Hoon, Nguan Soon Tan, Daphne Su-Lyn Gardner, Shih Ling Kao, E. Shyong Tai, Anna L. Gloyn, Adrian Kee Keong Teo

Source: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/04c9903c45a041a292092f38195e3bde

Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

Authors: Matias I Autio, Efthymios Motakis, Arnaud Perrin, Talal Bin Amin, Zenia Tiang, Dang Vinh Do, Jiaxu Wang, Joanna Tan, Shirley Suet Lee Ding, Wei Xuan Tan, Chang Jie Mick Lee, Adrian Kee Keong Teo, Roger SY Foo

Source: eLife, Vol 13 (2024)

Subject Terms: genomic safe harbour, targeted transgene expression, cell therapy, human embryonic stem cells, landing pad cassette, gene therapy, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/79592; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/6b5c6b6b01aa44959f46ae8b1df90239

HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells

Authors: Jun Wei Chan, Claire Wen Ying Neo, Soumita Ghosh, Hyungwon Choi, Su Chi Lim, E. Shyong Tai, Adrian Kee Keong Teo

Source: Cell Death and Disease, Vol 14, Iss 5, Pp 1-11 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/cab6e1d39cf74493963c557b486ff8f6

FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro

Authors: Hwee Hui Lau, Nur Shabrina Amirruddin, Larry Sai Weng Loo, Jun Wei Chan, Elhadi Iich, Vidhya Gomathi Krishnan, Shawn Hoon, Adrian Kee Keong Teo

Source: iScience, Vol 26, Iss 8, Pp 107265- (2023)

Subject Terms: Biological sciences, Molecular biology, Developmental biology, Embryology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223013421; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/153f3a71a5cf42f8b50ec86c660d7861

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells

Authors: Blaise Su Jun Low, Chang Siang Lim, Shirley Suet Lee Ding, Yaw Sing Tan, Natasha Hui Jin Ng, Vidhya Gomathi Krishnan, Su Fen Ang, Claire Wen Ying Neo, Chandra S. Verma, Shawn Hoon, Su Chi Lim, E. Shyong Tai, Adrian Kee Keong Teo

Source: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/03229c3f34e24347bae20e13a756621c

Multidisciplinary Effort to Drive Precision-Medicine for the Future

Authors: Dewei Kong, Haojie Yu, Xueling Sim, Kevin White, E. Shyong Tai, Markus Wenk, Adrian Kee Keong Teo

Source: Frontiers in Digital Health, Vol 4 (2022)

Subject Terms: precision medicine, big data, omics technologies, data collection, data processing, results interpretation, Medicine, Public aspects of medicine, RA1-1270, Electronic computers. Computer science, QA75.5-76.95

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fdgth.2022.845405/full; https://doaj.org/toc/2673-253X

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HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells

Authors: Natasha Hui Jin Ng, Joanita Binte Jasmen, Chang Siang Lim, Hwee Hui Lau, Vidhya Gomathi Krishnan, Juned Kadiwala, Rohit N. Kulkarni, Helge Ræder, Ludovic Vallier, Shawn Hoon, Adrian Kee Keong Teo

Source: iScience, Vol 16, Iss , Pp 192-205 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004219301695; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/a1abfe83df4245a69333e08ebafd2f68

Protocol for the generation of pancreatic and hepatic progenitors from human pluripotent stem cells for gene regulatory assays

Authors: Lay Shuen Tan, Resilind Su Ern Chew, Natasha Hui Jin Ng, Adrian Kee Keong Teo

Source: STAR Protocols, Vol 2, Iss 2, Pp 100471- (2021)

Subject Terms: Cell culture, Cell-based Assays, Molecular Biology, Gene Expression, Stem Cells, Cell Differentiation, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166721001787; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/4f2a3b20b9ef429c80c481f160077319

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

Authors: Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alpy, Alice P.S. Kong, Peter I. Benke, Federico Torta, Adrian Kee Keong Teo, Isabelle Leclerc, Michele Solimena, Dale B. Wigley, Guy A. Rutter

Source: Molecular Metabolism, Vol 40, Iss , Pp 101015- (2020)

Subject Terms: Type 2 diabetes, Pancreatic β-cell, Lipid transporter, Insulin granule biogenesis, Phosphoinositides, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877820300892; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/075506f07a044c31be2e44b42ccc2527

Metformin from mother to unborn child – Are there unwarranted effects?

Authors: Linh Nguyen, Shiao-Yng Chan, Adrian Kee Keong Teo

Source: EBioMedicine, Vol 35, Iss , Pp 394-404 (2018)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396418303335; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/05b7281f014446c3af7d907dbf995347

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation

Authors: Ivan Achel Valdez, Ercument Dirice, Manoj K. Gupta, Jun Shirakawa, Adrian Kee Keong Teo, Rohit N. Kulkarni

Source: Cell Reports, Vol 15, Iss 3, Pp 460-470 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716302923; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/3d2426a03aae4b6a9b2a66231d7daf18

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

Authors: Adrian Kee Keong Teo, Hwee Hui Lau, Ivan Achel Valdez, Ercument Dirice, Erling Tjora, Helge Raeder, Rohit N. Kulkarni

Source: Stem Cell Reports, Vol 6, Iss 3, Pp 357-367 (2016)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213671116000242; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/1e50b8eeb0db4aaa9af14fea5adde2e2

Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools

Authors: Adrian Kee Keong Teo, Manoj K. Gupta, Alessandro Doria, Rohit N. Kulkarni

Source: Molecular Metabolism, Vol 4, Iss 9, Pp 593-604 (2015)

Subject Terms: Diabetes, Metabolic disease, Pluripotent stem cells, Genome editing, CRISPR/Cas, Disease modeling, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877815001192; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/57d75d5070a346a3b3b8de7f23f577c8

PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells

Authors: Adrian Kee Keong Teo, Norihiro Tsuneyoshi, Shawn Hoon, Ee Kim Tan, Lawrence W. Stanton, Christopher V.E. Wright, N. Ray Dunn

Source: Stem Cell Reports, Vol 4, Iss 4, Pp 578-590 (2015)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213671115000715; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/edccf6a89b0245c78b39389973734993

Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling in Absence of Serum

Authors: Adrian Kee Keong Teo, Ivan Achel Valdez, Ercument Dirice, Rohit N. Kulkarni

Source: Stem Cell Reports, Vol 3, Iss 1, Pp 5-14 (2014)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213671114001489; https://doaj.org/toc/2213-6711

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Knowledge gaps in rodent pancreas biology: taking human pluripotent stem cell-derived pancreatic beta cells into our own hands

Authors: Munirah Mohamad Santosa, Blaise Su Jun Low, Nicole Min Qian Pek, Adrian Kee Keong Teo

Source: Frontiers in Endocrinology, Vol 6 (2016)

Subject Terms: Pancreas, human, differentiation, beta cell, islet, Pluripotent stem cell, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00194/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/d8e188542a274b95be3f066f95ac238a

Knowledge Gaps in Rodent Pancreas Biology: Taking Human Pluripotent Stem Cell-Derived Pancreatic Beta Cells into Our Own Hands.

Authors: Santosa, Munirah Mohamad, Blaise Su Jun Low, Nicole Min Qian Pek, Adrian Kee Keong Teo

Source: Frontiers in Endocrinology; 1/14/2016, p1-9, 9p

Subject Terms: PLURIPOTENT stem cells, PANCREATIC beta cells, LABORATORY rodents