Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic syndrome

Authors: Adamson, Samantha E., Adak, Sangeeta, Petersen, Max C., Higgins, Dustin, Spears, Larry D., Zhang, Rong Mei, Cedeno, Andrea, McKee, Alexis, Kumar, Aswathi, Singh, Sudhir, Hsu, Fong-Fu, McGill, Janet B., Semenkovich, Clay F.

Source: In Journal of Lipid Research March 2024 65(3)

Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria

Authors: Speck, Sarah L., Bhatt, Dhaval P., Zhang, Qiang, Adak, Sangeeta, Yin, Li, Dong, Guifang, Feng, Chu, Zhang, Wei, Ben Major, M., Wei, Xiaochao, Semenkovich, Clay F.

Source: In Cell Reports 28 November 2023 42(11)

Palmitoylation couples insulin hypersecretion with β cell failure in diabetes

Authors: Dong, Guifang, Adak, Sangeeta, Spyropoulos, George, Zhang, Qiang, Feng, Chu, Yin, Li, Speck, Sarah L., Shyr, Zeenat, Morikawa, Shuntaro, Kitamura, Rie Asada, Kathayat, Rahul S., Dickinson, Bryan C., Ng, Xue Wen, Piston, David W., Urano, Fumihiko, Remedi, Maria S., Wei, Xiaochao, Semenkovich, Clay F.

Source: In Cell Metabolism 7 February 2023 35(2):332-344

Glucose-mediated de novo lipogenesis in photoreceptors drives early diabetic retinopathy

Authors: Rajagopal, Rithwick, Sylvester, Beau, Zhang, Sheng, Adak, Sangeeta, Wei, Xiaochao, Bowers, Megan, Jessberger, Sebastian, Hsu, Fong-Fu, Semenkovich, Clay F.

Source: In Journal of Biological Chemistry September 2021 297(3)

Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration

Authors: Spears, Larry D., Adak, Sangeeta, Dong, Guifang, Wei, Xiaochao, Spyropoulos, George, Zhang, Qiang, Yin, Li, Feng, Chu, Hu, Donghua, Lodhi, Irfan J., Hsu, Fong-Fu, Rajagopal, Rithwick, Noguchi, Kevin K., Halabi, Carmen M., Brier, Lindsey, Bice, Annie R., Lananna, Brian V., Musiek, Erik S., Avraham, Oshri, Cavalli, Valeria, Holth, Jerrah K., Holtzman, David M., Wozniak, David F., Culver, Joseph P., Semenkovich, Clay F.

Source: In Journal of Lipid Research 2021 62

Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth.

Authors: Ghosh, Soma¹, Bandyopadhyay, Saumya¹, Smith, Danielle M.¹, Adak, Sangeeta², Semenkovich, Clay F.², Nagy, Laszlo^1,3, Wolfgang, Michael J.¹, O'Connor, Tamara J.¹, toconno7@jhmi.edu

Source: PLoS Pathogens; 2/22/2024, Vol. 20 Issue 2, p1-25, 25p

Endothelial Palmitoylation Cycling Coordinates Vessel Remodeling in Peripheral Artery Disease

Authors: Wei, Xiaochao, Adak, Sangeeta, Zayed, Mohamed, Yin, Li, Feng, Chu, Speck, Sarah L., Kathayat, Rahul S., Zhang, Qiang, Dickinson, Bryan C., Semenkovich, Clay F.

Source: Circulation research. 127(2):249-265

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190134611.0x000001&indx=1&recIds=ETOCvdc_100190134611.0x000001

Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated

Authors: De Silva, Gayan S., Desai, Kshitij, Darwech, Malik, Naim, Uzma, Jin, Xiaohua, Adak, Sangeeta, Harroun, Nikolai, Sanchez, Luis A., Semenkovich, Clay F., Zayed, Mohamed A.

Source: Atherosclerosis. 287:38-45

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100096983180.0x000001&indx=1&recIds=ETOCvdc_100096983180.0x000001

Peroxisomal Lipid Synthesis Regulates Inflammation by Sustaining Neutrophil Membrane Phospholipid Composition and Viability

Authors: Lodhi, Irfan J., Wei, Xiaochao, Yin, Li, Feng, Chu, Adak, Sangeeta, Abou-Ezzi, Grazia, Hsu, Fong-Fu, Link, Daniel C., Semenkovich, Clay F.

Source: In Cell Metabolism 6 January 2015 21(1):51-64

Dynamic Analysis of the Epidermal Growth Factor (EGF) Receptor-ErbB2-ErbB3 Protein Network by Luciferase Fragment Complementation Imaging

Authors: Macdonald-Obermann, Jennifer L., Adak, Sangeeta, Landgraf, Ralf, Piwnica-Worms, David ^{*‡, *‡}, Pike, Linda J.

Source: In Journal of Biological Chemistry 18 October 2013 288(42):30773-30784

The Membrane-proximal Intracellular Domain of the Epidermal Growth Factor Receptor Underlies Negative Cooperativity in Ligand Binding

Authors: Adak, Sangeeta, Yang, Katherine S., Macdonald-Obermann, Jennifer, Pike, Linda J.

Source: In Journal of Biological Chemistry 30 December 2011 286(52):45146-45155

The Tethering Arm of the EGF Receptor Is Required for Negative Cooperativity and Signal Transduction

Authors: Adak, Sangeeta, DeAndrade, Diana, Pike, Linda J.

Source: In Journal of Biological Chemistry 14 January 2011 286(2):1545-1555

Dynamic and electrokinetic behavior of erythrocyte membrane in diabetes mellitus and diabetic cardiovascular disease

Authors: Adak, Sangeeta, Chowdhury, Subhankar, Bhattacharyya, Maitree

Source: In BBA - General Subjects February 2008 1780(2):108-115

Enhanced oxygen releasing capacity and oxidative stress in diabetes mellitus and diabetes mellitus-associated cardiovascular disease: A comparative study

Authors: Saha, Arindam, Adak, Sangeeta, Chowdhury, Subhankar, Bhattacharyya, Maitree

Source: In Clinica Chimica Acta 2005 361(1):141-149

Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.

Authors: Smith, Amanda M., LaValle, Taylor A., Shinawi, Marwan, Ramakrishnan, Sai M., Abel, Haley J., Hill, Cheryl A., Kirkland, Nicole M., Rettig, Michael P., Helton, Nichole M., Heath, Sharon E., Ferraro, Francesca, Chen, David Y., Adak, Sangeeta, Semenkovich, Clay F., Christian, Diana L., Martin, Jenna R., Gabel, Harrison W., Miller, Christopher A., Ley, Timothy J.

Source: Nature Communications; 7/27/2021, Vol. 12 Issue 1, p1-18, 18p

Subject Terms: HUMAN phenotype, GENETIC mutation, LABORATORY mice, EPIGENETICS, ACUTE myeloid leukemia, EXOMES, SOMATIC mutation

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1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure.

Authors: DONG, GUIFANG, WEI, XIAOCHAO, YIN, LI, FENG, CHU, ADAK, SANGEETA, SHYR, ZEENAT A., ZHANG, QIANG, MORIKAWA, SHUNTARO, ASADA, RIE, URANO, FUMIHIKO, REMEDI, MARIA S., SEMENKOVICH, CLAY F.

Source: Diabetes; 2020 Supplement, Vol. 69, pN.PAG-N.PAG, 1p