Drug screening on digital microfluidics for cancer precision medicine

Authors: Jiao Zhai, Yingying Liu, Weiqing Ji, Xinru Huang, Ping Wang, Yunyi Li, Haoran Li, Ada Hang-Heng Wong, Xiong Zhou, Ping Chen, Lianhong Wang, Ning Yang, Chi Chen, Haitian Chen, Pui-In Mak, Chu-Xia Deng, Rui Martins, Mengsu Yang, Tsung-Yi Ho, Shuhong Yi, Hailong Yao, Yanwei Jia

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0b96413517f94cd3a5bdbc4526edd9e0

Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy

Authors: Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong

Source: BMJ Oncology, Vol 3, Iss 1 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://bmjoncology.bmj.com/content/3/1/e000128.full; https://doaj.org/toc/2752-7948

Access URL: https://doaj.org/article/20e430b979254079aac5e5c334ae163c

Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

Authors: Ren-Bo Ding, Ping Chen, Barani Kumar Rajendran, Xueying Lyu, Haitao Wang, Jiaolin Bao, Jianming Zeng, Wenhui Hao, Heng Sun, Ada Hang-Heng Wong, Monica Vishnu Valecha, Eun Ju Yang, Sek Man Su, Tak Kan Choi, Shuiming Liu, Kin Iong Chan, Ling-Lin Yang, Jingbo Wu, Kai Miao, Qiang Chen, Joong Sup Shim, Xiaoling Xu, Chu-Xia Deng

Source: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/87f829886bef4facb841e43c9c543db3

Definition of a new blood cell count score for early survival prediction for non-small cell lung cancer patients treated with atezolizumab: Integrated analysis of four multicenter clinical trials

Authors: Jian-Guo Zhou, Ada Hang-Heng Wong, Haitao Wang, Su-Han Jin, Fangya Tan, Yu-Zhong Chen, Si-Si He, Gang Shen, Benjamin Frey, Rainer Fietkau, Markus Hecht, Shamus R. Carr, Ruihong Wang, Bo Shen, David S. Schrump, Hu Ma, Udo S. Gaipl

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: NSCLC, atezolizumab, biomarker, blood cell count, clinical trial, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.961926/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0510a79ed4e94420ac663f83d39095e3

Editorial: Uncovering Drug Resistance During Cancer Therapy

Authors: Haitao Wang, Rui-Hong Wang, Jian-Guo Zhou, Weilong Hou, Ada Hang-Heng Wong

Source: Frontiers in Genetics, Vol 13 (2022)

Subject Terms: cancer, oncology, cancer therapy, drug resistance, next generation sequencing, biomarkers, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.945842/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/9536437af2794727b6a793bb81aca037

Elucidation of the Application of Blood Test Biomarkers to Predict Immune-Related Adverse Events in Atezolizumab-Treated NSCLC Patients Using Machine Learning Methods

Authors: Jian-Guo Zhou, Ada Hang-Heng Wong, Haitao Wang, Fangya Tan, Xiaofei Chen, Su-Han Jin, Si-Si He, Gang Shen, Yun-Jia Wang, Benjamin Frey, Rainer Fietkau, Markus Hecht, Hu Ma, Udo S. Gaipl

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: blood test, irAE prediction, NSCLC, atezolizumab, machine learning, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.862752/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5e92e0567a3346cc9a5c65ab03834cfe

Candida albicans gains azole resistance by altering sphingolipid composition

Authors: Jiaxin Gao, Haitao Wang, Zeyao Li, Ada Hang-Heng Wong, Yi-Zheng Wang, Yahui Guo, Xin Lin, Guisheng Zeng, Haoping Liu, Yue Wang, Jianbin Wang

Source: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f9482aff0bce438592c86a1e3d00feb0

Drug screening of cancer cell lines and human primary tumors using droplet microfluidics

Authors: Ada Hang-Heng Wong, Haoran Li, Yanwei Jia, Pui-In Mak, Rui Paulo da Silva Martins, Yan Liu, Chi Man Vong, Hang Cheong Wong, Pak Kin Wong, Haitao Wang, Heng Sun, Chu-Xia Deng

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/09904b3aa3004ace89370e211250ec32

Author Correction: Candida albicans gains azole resistance by altering sphingolipid composition

Authors: Jiaxin Gao, Haitao Wang, Zeyao Li, Ada Hang-Heng Wong, Yi-Zheng Wang, Yahui Guo, Xin Lin, Guisheng Zeng, Yue Wang, Jianbin Wang

Source: Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3582b7471ba2477d9ce9c992f7b0b209

Pph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans.

Authors: Haitao Wang, Jiaxin Gao, Wanjie Li, Ada Hang-Heng Wong, Kangdi Hu, Kun Chen, Yue Wang, Jianli Sang

Source: PLoS ONE, Vol 7, Iss 5, p e37246 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3351423?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/58f38800322b4f33a644d3a9666089e1

Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel.

Authors: Haitao Wang, Sen Guo, Seung-Jin Kim, Fangyuan Shao, Joshua Wing Kei Ho, Kuan Un Wong, Zhengqiang Miao, Dapeng Hao, Ming Zhao, Jun Xu, Jianming Zeng, Koon Ho Wong, Lijun Di, Ada Hang-Heng Wong, Xiaoling Xu, Chu-Xia Deng

Source: Theranostics; 2021, Vol. 11 Issue 5, p2442-2459, 18p

Crystal Structure of the Yeast Metacaspase Yca1.

Authors: Ada Hang-Heng Wong^1,2, Chuangye Yan^2,3, Yigong Shi^1,2 shi-lab@tsinghua.edu.cn

Source: Journal of Biological Chemistry. 8/24/2012, Vol. 287 Issue 35, p29251-29259. 9p.

Subject Terms: *CASPASES, *YEAST fungi, *CRYSTAL structure, *SACCHAROMYCES cerevisiae, *CYSTEINE proteinases, *APOPTOSIS, *CELL death

A Novel and Robust Single-cell Trapping Method on Digital Microfluidics

Authors: Jiao Zhai, Haoran Li, Ada Hang Heng Wong, Cheng Dong, Shuhong Yi, Yanwei Jia, Pui-In Mak, Chuxia Deng, Rui Martins

Source: Bio-Protocol, Vol 10, Iss 19 (2020)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://bio-protocol.org/en/bpdetail?id=3769&type=0; https://doaj.org/toc/2331-8325

Access URL: https://doaj.org/article/f6790122ea6941e59b27379bbe1507db