Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes

Authors: Hourani, Tetiana, Eivazitork, Mahtab, Balendran, Thivya, MC. Lee, Kevin, Hamilton, John A., Zhu, Hong-Jian, Iaria, Josephine, Morokoff, Andrew P., Luwor, Rodney B., Achuthan, Adrian A.

Source: In Molecular Immunology February 2024 166:101-109

CCL17/TARC in autoimmunity and inflammation—not just a T‐cell chemokine

Authors: Lupancu, Tanya J, Eivazitork, Mahtab, Hamilton, John A, Achuthan, Adrian A, Lee, Kevin M‐C

Source: Immunology and cell biology. 101(7):600-609

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189965449.0x000001&indx=1&recIds=ETOCvdc_100189965449.0x000001

Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis

Authors: Lupancu, Tanya J., Lee, Kevin M.C., Eivazitork, Mahtab, Hor, Cecil, Fleetwood, Andrew J., Cook, Andrew D., Olshansky, Moshe, Turner, Stephen J., de Steiger, Richard, Lim, Keith, Hamilton, John A., Achuthan, Adrian A.

Source: In iScience 20 October 2023 26(10)

The GM-CSF/CCL17 pathway in obesity-associated osteoarthritic pain and disease in mice

Authors: Shin, Heonsu ^{†, ¶}, Prasad, Varun ^{†, ¶}, Lupancu, Tanya ^{†, ¶}, Malik, Shveta ^{†, ¶}, Achuthan, Adrian ^{†, ¶}, Biondo, Mark ^{‡, ¶}, Kingwell, Bronwyn A. ^{‡, ¶}, Thiem, Manja ^{§, ¶}, Gottschalk, Marlene ^{§, ¶}, Weighardt, Heike ^{§, ¶}, Förster, Irmgard ^{§, ¶}, de Steiger, Richard ^{#, ¶}, Hamilton, John A. ^{†, ║, ¶}, Lee, Kevin M.-C. ^{†, ¶}

Source: In Osteoarthritis and Cartilage October 2023 31(10):1327-1341

The Role of TIM-3 in Glioblastoma Progression.

Authors: Ahmady, Farah, Sharma, Amit, Achuthan, Adrian A., Kannourakis, George, Luwor, Rodney B.

Source: Cells (2073-4409); Mar2025, Vol. 14 Issue 5, p346, 19p

Subject Terms: IMMUNE checkpoint proteins, T cell receptors, HEPATITIS A virus cellular receptors, GLIOBLASTOMA multiforme, PROGNOSIS

Transforming growth factor-β in tumor microenvironment: Understanding its impact on monocytes and macrophages for its targeting.

Authors: Hourani, Tetiana, Sharma, Amit, Luwor, Rodney B., Achuthan, Adrian A.

Source: International Reviews of Immunology; 2025, Vol. 44 Issue 2, p82-97, 16p

Subject Terms: TRANSFORMING growth factors, TUMOR microenvironment, IMMUNE response, TUMOR growth, CANCER invasiveness

Targeting GM-CSF in inflammatory and autoimmune disorders

Authors: Achuthan, Adrian A. ^*, Lee, Kevin M.C., Hamilton, John A.

Source: In Seminars in Immunology April 2021 54

Therapeutic blockade of CCL17 in obesity-exacerbated osteoarthritic pain and disease.

Authors: Lee, Kevin Ming-Chin, Lupancu, Tanya, Keenan, Stacey N., Bing, Georgina, Achuthan, Adrian A., Biondo, Mark, Lieu, Kim Gia, Watt, Matthew J., Maraskovsky, Eugene, Kingwell, Bronwyn A., Hamilton, John A.

Source: PLoS ONE; 1/16/2025, Vol. 20 Issue 1, p1-14, 14p

Subject Terms: GLUCOSE tolerance tests, HIGH-fat diet, INSULIN resistance, JOINT injuries, TREATMENT effectiveness

IL-23p19 in osteoarthritic pain and disease.

Authors: Lee, Kevin M.-C., Lupancu, Tanya, Achuthan, Adrian A., de Steiger, Richard, Hamilton, John A.

Source: Osteoarthritis & Cartilage; Nov2024, Vol. 32 Issue 11, p1413-1418, 6p

CCL17 in Inflammation and Pain

Authors: Lee, Kevin M.-C., Jarnicki, Andrew, Achuthan, Adrian, Fleetwood, Andrew J., Anderson, Gary P., Ellson, Christian, Feeney, Maria, Modis, Louise K., Smith, Julia E., Hamilton, John A.

Source: Journal of immunology. 205(1):213-222

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624156017&indx=1&recIds=ETOCRN624156017

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

Authors: Hsu, Amy T., Lupancu, Tanya J., Lee, Ming-Chin, Fleetwood, Andrew J., Cook, Andrew D., Hamilton, John A., Achuthan, Adrian

Source: In Journal of Biological Chemistry 20 July 2018 293(29):11415-11423

GM-CSF— and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

Authors: Lee, Ming-Chin, Lacey, Derek C., Fleetwood, Andrew J., Achuthan, Adrian, Hamilton, John A., Cook, Andrew D.

Source: Journal of immunology. 202(10):3033-3040

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620020410&indx=1&recIds=ETOCRN620020410

Dexamethasone ameliorates arthritis through epigenetic and transcriptional regulation of CCL17 production

Authors: Achuthan, Adrian

Source: FASEB journal. 36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196444542.0x000001&indx=1&recIds=ETOCvdc_100196444542.0x000001

Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization

Authors: Ming-Chin Lee, Kevin, Achuthan, Adrian A., De Souza, David P., Lupancu, Tanya J., Binger, Katrina J., Lee, Man K.S., Xu, Yangsong, McConville, Malcolm J., de Weerd, Nicole A., Dragoljevic, Dragana, Hertzog, Paul J., Murphy, Andrew J., Hamilton, John A., Fleetwood, Andrew J.

Source: Cell reports. 39(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169712588.0x000001&indx=1&recIds=ETOCvdc_100169712588.0x000001

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity

Authors: Achuthan, Adrian, Aslam, Ahmad, Nguyen, Quyen, Lam, Pui-Yeng, Fleetwood, Andrew, Frye, Ashlee, Louis, Cynthia, Lee, Ming-Chin, Smith, Julia, Cook, Andrew, Olshansky, Moshe, Turner, Stephen, Hamilton, John

Source: Cell death and disease. 9(3):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112269701.0x000001&indx=1&recIds=ETOCvdc_100112269701.0x000001

CSF-1 in Inflammatory and Arthritic Pain Development

Authors: Saleh, Reem, Lee, Ming-Chin, Khiew, Stella H., Louis, Cynthia, Fleetwood, Andrew J., Achuthan, Adrian, Förster, Irmgard, Cook, Andrew D., Hamilton, John A.

Source: Journal of immunology. 201(7):2042-2053

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617418630&indx=1&recIds=ETOCRN617418630

Cytokine-Induced Acute Inflammatory Monoarticular Arthritis

Authors: Achuthan, Adrian, Lee, Ming-Chin, Saleh, Reem, Fleetwood, Andrew J., Hamilton, John A., Cook, Andrew D.

Source: Methods in molecular biology. 1784:215-224

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN616121605&indx=1&recIds=ETOCRN616121605

CCL17 blockade as a therapy for osteoarthritis pain and disease

Authors: Lee, Ming-Chin, Saleh, Reem, Achuthan, Adrian, Fleetwood, Andrew, Förster, Irmgard, Hamilton, John, Cook, Andrew

Source: Arthritis research & therapy. 20(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161829414.0x000001&indx=1&recIds=ETOCvdc_100161829414.0x000001

Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System: IMPLICATIONS FOR PERIODONTITIS

Authors: Fleetwood, Andrew J., O'Brien-Simpson, Neil M., Veith, Paul D., Lam, Roselind S., Achuthan, Adrian, Cook, Andrew D., Singleton, William, Lund, Ida K., Reynolds, Eric C., Hamilton, John A.

Source: In Journal of Biological Chemistry 26 June 2015 290(26):16031-16042

Introduction to the Special Issue: The regulation of the immune system by colony stimulating factors (CSFs) in the steady state and pathology

Authors: Hamilton, John A., Achuthan, Adrian A.

Source: Seminars in immunology. 54

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100150595468.0x000001&indx=1&recIds=ETOCvdc_100150595468.0x000001