An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

Authors: Seijsing, Johan, Lindborg, Malin, Höidén-Guthenberg, Ingmarie, Bönisch, Heiko, Guneriusson, Elin, Frejd, Fredrik Y., Abrahmsén, Lars, Ekblad, Caroline, Löfblom, John, Uhlén, Mathias, Gräslund, Torbjörn

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Dec 01. 111(48), 17110-17115.

Access URL: https://www.jstor.org/stable/43278623

Polypeptide libraries with a predetermined scaffold

Structural basis for high-affinity HER2 receptor binding by an engineered protein

Authors: Eigenbrot, Charles, Ultsch, Mark, Dubnovitsky, Anatoly, Abrahmsén, Lars, Härd, Torleif, Bax, Adriaan

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Aug . 107(34), 15039-15044.

Access URL: https://www.jstor.org/stable/27862190

Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain

Authors: Andersen, Jan Terje, Pehrson, Rikard, Tolmachev, Vladimir, Daba, Muluneh Bekele, Abrahmsén, Lars, Ekblad, Caroline

Source: In Journal of Biological Chemistry 18 February 2011 286(7):5234-5241

Polypeptide

Compositions, methods and uses

Monoclonal Antibody-Superantigen Fusion Proteins: Tumor-Specific Agents for T-Cell-Based Tumor Therapy

Authors: Dohlsten, Mikael, Abrahmsen, Lars, Bjork, Per, Lando, Peter A., Hedlund, Gunnar, Forsberg, Goran, Brodin, Thomas, Forberg, Cecilia, Lind, Peter, Kalland, Terje

Source: Proceedings of the National Academy of Sciences of the United States of America, 1994 Sep . 91(19), 8945-8949.

Access URL: https://www.jstor.org/stable/2365946

Polypeptides having affinity for HER2

POLYPEPTIDES HAVING AFFINITY FOR HER2

POLYPEPTIDE LIBRARIES WITH A PREDETERMINED SCAFFOLD

COMPOSITIONS, METHODS AND USES

Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status.

Authors: Mejía-Hernández, Javier Octavio, Raghu, Dinesh, Caramia, Franco, Clemons, Nicholas, Fujihara, Kenji, Riseborough, Thomas, Teunisse, Amina, Jochemsen, Aart G., Abrahmsén, Lars, Blandino, Giovanni, Russo, Andrea, Gamell, Cristina, Fox, Stephen B., Mitchell, Catherine, Takano, Elena A., Byrne, David, Miranda, Panimaya Jeffreena, Saleh, Reem, Thorne, Heather, Sandhu, Shahneen

Source: Cancers; Aug2022, Vol. 14 Issue 16, p3947, 27p

Subject Terms: PROTEIN metabolism, THERAPEUTIC use of proteins, GENETIC mutation, ANIMAL experimentation, METASTASIS, APOPTOSIS, OXIDATIVE stress, CHALONES, PROSTATE tumors, MICE

Production of a truncated soluble human semicarbazide-sensitive amine oxidase mediated by a GST-fusion protein secreted from HEK293 cells

Authors: Öhman, Johan, Jakobsson, Emma, Källström, Ulla, Elmblad, Annette, Ansari, Akbar, Kalderén, Christina, Robertson, Elinor, Danielsson, Eva, Gustavsson, Anna-Lena, Varadi, Andrea, Ekblom, Jonas, Holmgren, Erik, Doverskog, Magnus, Abrahmsén, Lars, Nilsson, Joakim

Source: In Protein Expression and Purification 2006 46(2):321-331

Active site variability of type 1 11β-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons

Authors: Hult, Malin, Shafqat, Naeem, Elleby, Björn, Mitschke, Doreen, Svensson, Stefan, Forsgren, Margareta, Barf, Tjeerd, Vallgårda, Jerk, Abrahmsen, Lars, Oppermann, Udo

Source: In Molecular and Cellular Endocrinology 2006 248(1):26-33

The Crystal Structure of Guinea Pig 11β-Hydroxysteroid Dehydrogenase Type 1 Provides a Model for Enzyme-Lipid Bilayer Interactions

Authors: Ogg, Derek ^***, Elleby, Björn ^***, Norström, Carina ^***, Stefansson, Karin ^***, Abrahmsén, Lars ^{‡, ***}, Oppermann, Udo ^{§, ¶}, Svensson, Stefan ^{∥, ***}

Source: In Journal of Biological Chemistry 4 February 2005 280(5):3789-3794

High-level production and optimization of monodispersity of 11β-hydroxysteroid dehydrogenase type 1

Authors: Elleby, Björn ^*, Svensson, Stefan, Wu, Xiaoqiu, Stefansson, Karin, Nilsson, Joakim, Hallén, Dan, Oppermann, Udo, Abrahmsén, Lars

Source: In BBA - Proteins and Proteomics 2004 1700(2):199-207

Comparative Enzymology of 11β-Hydroxysteroid Dehydrogenase Type 1 from Glucocorticoid Resistant (Guinea Pig) Versus Sensitive (Human) Species

Authors: Shafqat, Naeem ^‡, Elleby, Björn ^§, Svensson, Stefan ^§, Shafqat, Jawed ^‡, Jörnvall, Hans ^‡, Abrahmsen, Lars ^§, Oppermann, Udo ^{‡, ¶}

Source: In Journal of Biological Chemistry 17 January 2003 278(3):2030-2035

Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).

Authors: Degtjarik, Oksana, Golovenko, Dmitrij, Diskin-Posner, Yael, Abrahmsén, Lars, Rozenberg, Haim, Shakked, Zippora

Source: Nature Communications; 12/3/2021, Vol. 12 Issue 1, p1-17, 17p

Subject Terms: SMALL molecules, BIOACTIVE compounds, P53 antioncogene, TRANSCRIPTION factors, CARCINOGENESIS, P53 protein, METHYLENE compounds

Expression of human insulin-like growth factor I in bacteria: use of optimized gene fusion vectors to facilitate protein purification.

Authors: Moks, Tomas, Abrahmsén, Lars, Holmgren, Erik

Source: Biochemistry; August 25 1987, Vol. 26, p5239-5244, 6p

Probing the mechanism and improving the rate of substrate-assisted catalysis in subtilisin BPN′.

Authors: Carter, Paul, Abrahmsén, Lars, Wells, James A.

Source: Biochemistry; June 25 1991, Vol. 30, p6142-6148, 7p