Utility of AI digital pathology as an aid for pathologists scoring fibrosis in MASH

Authors: Abdurrachim, Desiree ^{1, ⁎}, Lek, Serene ², Ong, Charlene Zhi Lin ¹, Wong, Chun Kit ¹, Zhou, Yongqi ¹, Wee, Aileen ³, Soon, Gwyneth ³, Kendall, Timothy J. ⁴, Idowu, Michael O. ⁵, Hendra, Christopher ¹, Saigal, Ashmita ⁶, Krishnan, Radha ⁷, Chng, Elaine ², Tai, Dean ², Ho, Gideon ², Forest, Thomas ⁸, Raji, Annaswamy ⁹, Talukdar, Saswata ⁶, Chin, Chih-Liang ⁶, Baumgartner, Richard ¹⁰, Engel, Samuel S. ⁹, Ali, Asad Abu Bakar ¹, Kleiner, David E. ¹¹, Sanyal, Arun J. ¹²

Source: In Journal of Hepatology November 2024

Dexamethasone inhibits regeneration and causes ventricular aneurysm in the neonatal porcine heart after myocardial infarction

Authors: Tao, Zhonghao, Loo, Szejie, Su, Liping, Abdurrachim, Desiree, Lalic, Janise, Lee, Teck Hock, Chen, Xin, Tan, Ru-San, Zhang, Jianyi, Ye, Lei

Source: In Journal of Molecular and Cellular Cardiology July 2020 144:15-23

A porcine model of heart failure with preserved ejection fraction: magnetic resonance imaging and metabolic energetics

Authors: Charles, Christopher J., Lee, Philip, Li, Renee R., Yeung, Teresa, Ibraham Mazlan, Stephane M., Tay, Zhi Wei, Abdurrachim, Desiree, Teo, Xing Qi, Wang, Wei‐Hsin, Kleijn, Dominique P.V., Cozzone, Patrick J., Lam, Carolyn S.P., Richards, A. Mark

Source: ESC heart failure. 7(1):93-103

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Evaluation of cardiac energetics by non-invasive 31P magnetic resonance spectroscopy

Authors: Abdurrachim, Desiree, Prompers, Jeanine J.

Source: In BBA - Molecular Basis of Disease May 2018 1864(5) Part B:1939-1948

A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart

Authors: Abdurrachim, Desiree, Woo, Chern, Teo, Xing, Chan, Wei, Radda, George, Lee, Philip

Source: Scientific reports. 9(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129215849.0x000001&indx=1&recIds=ETOCvdc_100129215849.0x000001

Cardiac metabolic modulation upon low‐carbohydrate low‐protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized 13C pyruvate, butyrate and acetoacetate probes

Authors: Abdurrachim, Desiree, Teo, Xing Qi, Woo, Chern Chiuh, Ong, Sing Yee, Salleh, Nurul Farhana, Lalic, Janise, Tan, Ru‐San, Lee, Philip Teck Hock

Source: Diabetes, obesity & metabolism. 21(4):949-960

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Empagliflozin reduces myocardial ketone utilization while preserving glucose utilization in diabetic hypertensive heart disease: A hyperpolarized 13C magnetic resonance spectroscopy study

Authors: Abdurrachim, Desiree, Teo, Xing Qi, Woo, Chern Chiuh, Chan, Wei Xin, Lalic, Janise, Lam, Carolyn S. P., Lee, Philip Teck Hock

Source: Diabetes, obesity & metabolism. 21(2):357-365

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100077033562.0x000001&indx=1&recIds=ETOCvdc_100077033562.0x000001

Early Regenerative Capacity in the Porcine Heart

Authors: Ye, Lei, D'Agostino, Giuseppe, Loo, Sze Jie, Wang, Chen Xu, Su, Li Ping, Tan, Shi Hua, Tee, Gui Zhen, Pua, Chee Jian, Pena, Edgar Macabe, Cheng, Redmond Belen, Chen, Way Cherng, Abdurrachim, Desiree, Lalic, Janise, Tan, Ru San, Lee, Teck Hock, Zhang, JianYi, Cook, Stuart Alexander

Source: Circulation. 138(24):2798-2808

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100073303104.0x000001&indx=1&recIds=ETOCvdc_100073303104.0x000001

Leukotriene B4 receptor 1 does not mediate disease progression in a mouse model of liver fibrosis.

Authors: Coyne, Erin S., Yilin Nie, Abdurrachim, Desiree, Zhi Lin Ong, Charlene, Yongqi Zhou, Bakar Ali, Asad Abu, Meyers, Stacey, Grein, Jeff, Blumenschein, Wendy, Gongol, Brendan, Yang Liu, Hugelshofer, Cedric, Carballo-Jane, Ester, Talukdar, Saswata

Source: Biochemical Journal; Feb2024, Vol. 481 Issue 3, p177-190, 14p

Subject Terms: HEPATIC fibrosis, DISEASE progression, LABORATORY mice, OPIOID receptors, ANIMAL disease models, FATTY liver

Small animal cardiovascular MR imaging and spectroscopy

Authors: Bakermans, Adrianus J., Abdurrachim, Desiree, Moonen, Rik P.M., Motaal, Abdallah G., Prompers, Jeanine J., Strijkers, Gustav J., Vandoorne, Katrien, Nicolay, Klaas

Source: In Progress in Nuclear Magnetic Resonance Spectroscopy August 2015 88-89:1-47

Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo

Authors: Abdurrachim, Desiree, Ciapaite, Jolita, Wessels, Bart, Nabben, Miranda, Luiken, Joost J.F.P., Nicolay, Klaas, Prompers, Jeanine J.

Source: In BBA - Molecular and Cell Biology of Lipids October 2014 1841(10):1525-1537

Acute inflammation contributes to regeneration in the neonatal porcine heart

Authors: Tao, Zhonghao, Loo, Szejie, Su, Liping, Tan, Shihua, Abdurrachim, Desiree, Lalic, Janise, Lee, Teck Hock, Tan, Rusan, Cook, Stuart, Ye, Lei

Source: Journal of molecular and cellular cardiology. 140(S):32-32

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100113426195.0x000001&indx=1&recIds=ETOCvdc_100113426195.0x000001

Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction.

Authors: Shi Hua Tan, Sze Jie Loo, Yu Gao, Zhong Hao Tao, Li Ping Su, Chen Xu Wang, Zhang, Sophia L., Yong Hui Mu, Ying Hua Cui, Abdurrachim, Desiree, Wei Hsin Wang, Lalic, Janise, Kheng Choon Lim, Jun Bu, Ru San Tan, Teck Hock Lee, Jianyi Zhang, Lei Ye

Source: Theranostics; 2021, Vol. 11 Issue 16, p7879-7895, 17p

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Cardiac metabolic modulation upon low‐carbohydrate low‐protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized ¹³C pyruvate, butyrate and acetoacetate probes.

Authors: Abdurrachim, Desiree¹, Teo, Xing Qi¹, Woo, Chern Chiuh¹, Ong, Sing Yee¹, Salleh, Nurul Farhana¹, Lalic, Janise¹, Tan, Ru‐San², Lee, Philip Teck Hock¹ philip_lee@sbic.a-star.edu.sg

Source: Diabetes, Obesity & Metabolism. Apr2019, Vol. 21 Issue 4, p949-960. 12p.

Subject Terms: *DIABETES, *HEART metabolism, *KETOGENIC diet, *LOW-carbohydrate diet, *LOW-protein diet, *NUCLEAR magnetic resonance spectroscopy

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Empagliflozin reduces myocardial ketone utilization while preserving glucose utilization in diabetic hypertensive heart disease: A hyperpolarized ¹³C magnetic resonance spectroscopy study.

Authors: Abdurrachim, Desiree¹, Teo, Xing Qi¹, Woo, Chern Chiuh¹, Chan, Wei Xin¹, Lalic, Janise¹, Lam, Carolyn S. P.^1,2, Lee, Philip Teck Hock¹ philip_lee@sbic.a-star.edu.sg

Source: Diabetes, Obesity & Metabolism. Feb2019, Vol. 21 Issue 2, p357-365. 9p.

Subject Terms: *EMPAGLIFLOZIN, *KETONES, *HEART failure treatment, *MYOCARDIUM physiology, *HYPERTENSION, *ACETOACETIC acid, *DIABETES complications, *GLUCOSE metabolism

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

Authors: Weeghel, Michel van, Abdurrachim, Desiree, Nederlof, Rianne, Argmann, Carmen A, Houtkooper, Riekelt H, Hagen, Jacob, Nabben, Miranda, Denis, Simone, Ciapaite, Jolita, Kolwicz, Stephen C

Source: Cardiovascular Research; 8/1/2018, Vol. 114 Issue 10, p1324-1334, 11p

Subject Terms: FATTY acid oxidation, CARNITINE palmitoyltransferase, HEART metabolism, MALONYL-coenzyme A, HEART function tests

High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes.

Authors: Verkaik, Melissa, Oranje, Maarten, Abdurrachim, Desiree, Goebel, Max, Gam, Zeineb, Prompers, Jeanine J., Helmes, Michiel, Wee, Pieter M., Velden, Jolanda, Kuster, Diederik W., Vervloet, Marc G., Eringa, Etto C.

Source: Physiological Reports; Apr2018, Vol. 6 Issue 7, p1-N.PAG, 13p

Subject Terms: FIBROBLAST growth factors, MITOGENS, HEART cells, FIBROBLAST growth factor receptors, KIDNEY failure

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