Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders

Authors: Tilal Elsaman, Magdi Awadalla Mohamed, Abozer Y. Elderdery, Abdullah Alsrhani, Badr Alzahrani, Heba Bassiony Ghanem, Jeremy Mills, Musaed Rayzah, Nasser A. N. Alzerwi, Afnan Al-sultan, Bandar Idrees, Fares Rayzah

Source: Frontiers in Pharmacology, Vol 16 (2025)

Subject Terms: fructose, diabetes, obesity, dyslipidemia, ketohexokinase, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1531512/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/71cc01bb58c14bb3a8feb89b2a7b5f2e

Substrate-Induced Structural Dynamics and Evolutionary Linkage of Siderophore-Iron ABC Transporters of Mycobacterium tuberculosis

Authors: Aisha Farhana, Abdullah Alsrhani, Hasan Ejaz, Muharib Alruwaili, Ayman A. M. Alameen, Emad Manni, Zafar Rasheed, Yusuf Saleem Khan

Source: Medicina, Vol 60, Iss 11, p 1891 (2024)

Subject Terms: Mycobacterium tuberculosis, siderophore-iron uptake, ABC transporters, Rv1348 (IrtA) and Rv2895c (IrtB), evolutionary linkage of transporters, drug targeting, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/1648-9144/60/11/1891; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144

Access URL: https://doaj.org/article/f4edcc69a5594bf988204786b5a815fb

Apigenin Provides Structural Protection to Human Fibrinogen against Nitrosative Stress: Biochemical and Molecular Insights

Authors: Aisha Farhana, Abdullah Alsrhani, Yusuf Saleem Khan, Mohammad Salahuddin, Mohammed Ubaidullah Sayeed, Zafar Rasheed

Source: Biomolecules, Vol 14, Iss 5, p 576 (2024)

Subject Terms: apigenin, peroxynitrite, fibrinogen, biochemical studies, oxidative damage, nitrosative stress, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/14/5/576; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/3ac50f272ae744b3a59dcfea7bea0ff5

Diagnosis and Stratification of COVID-19 Infections Using Differential Plasma Levels of D-Dimer: A Two-Center Study from Saudi Arabia

Authors: Abdullah Alsrhani, Ahmad Alshomar, Abozer Y Elderdery, Zafar Rasheed, Aisha Farhana

Source: Microbiology Research, Vol 14, Iss 1, Pp 67-76 (2023)

Subject Terms: COVID-19, D-dimer, disease severity, age, gender, biomarker, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2036-7481/14/1/6; https://doaj.org/toc/2036-7481

Access URL: https://doaj.org/article/76920e914f4d49b4941c6dd93211bff2

Gold nanoparticles attenuate the interferon-γ induced SOCS1 expression and activation of NF-κB p65/50 activity via modulation of microRNA-155-5p in triple-negative breast cancer cells

Authors: Aisha Farhana, Abdullah Alsrhani, Naila Rasheed, Zafar Rasheed

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: gold nanoparticles, SOCS1, interferon-γ, hsa-miR155-5p, NF-κB, triple negative breast cancer cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1228458/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/47914406586a4566bb4ea2888f098226

Syzygium cumini (L.) Extract-Derived Green Titanium Dioxide Nanoparticles Induce Caspase-Dependent Apoptosis in Hepatic Cancer Cells

Authors: Musaed Rayzah, Abozer Y. Elderdery, Nasser A. N. Alzerwi, Badr Alzahrani, Abdullah Alsrhani, Afnan Alsultan, Bandar Idrees, Fares Rayzah, Yaser Bakhsh, Ahmed M. Alzahrani, Suresh K. Subbiah, Pooi Ling Mok

Source: Plants, Vol 12, Iss 18, p 3174 (2023)

Subject Terms: Syzygium cumini, titanium oxide, nanomedicine, liver cancer, apoptosis, Botany, QK1-989

File Description: electronic resource

Relation: https://www.mdpi.com/2223-7747/12/18/3174; https://doaj.org/toc/2223-7747

Access URL: https://doaj.org/article/aeae708eb0b24b33bf84ed4ff9c867bc

Identification and Functional Characterization of Mutation in FYCO1 in Families with Congenital Cataract

Authors: Muhammad Ikram Ullah, Zaira Rehman, Rubina Dad, Abdullah Alsrhani, Muhammad Shakil, Heba Bassiony Ghanem, Ayman Ali Mohammed Alameen, Mohamed Farouk Elsadek, Lienda Bashier Eltayeb, Sajjad Ullah, Muhammad Atif

Source: Life, Vol 13, Iss 8, p 1788 (2023)

Subject Terms: congenital cataract, FYCO1, mutations, consanguineous families, in silico analysis, Science

File Description: electronic resource

Relation: https://www.mdpi.com/2075-1729/13/8/1788; https://doaj.org/toc/2075-1729

Access URL: https://doaj.org/article/28a97d32d3bf434c8e8af690b9c368c1

COVID-19 and comorbidities: Deleterious impact on infected patients

Authors: Hasan Ejaz, Abdullah Alsrhani, Aizza Zafar, Humera Javed, Kashaf Junaid, Abualgasim E. Abdalla, Khalid O.A. Abosalif, Zeeshan Ahmed, Sonia Younas

Source: Journal of Infection and Public Health, Vol 13, Iss 12, Pp 1833-1839 (2020)

Subject Terms: SARS-CoV-2, Comorbidities, COVID-19, Diabetes, Chronic obstructive pulmonary disease, Cardiovascular diseases, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1876034120305943; https://doaj.org/toc/1876-0341

Access URL: https://doaj.org/article/1f602ac1bcc34ab79580322d836da1e9

Gold Nanoparticles Inhibit PMA-Induced MMP-9 Expression via microRNA-204-5p Upregulation and Deactivation of NF-κBp65 in Breast Cancer Cells

Authors: Aisha Farhana, Abdullah Alsrhani, Nazia Nazam, Muhammad Ikram Ullah, Yusuf Saleem Khan, Zafar Rasheed

Source: Biology, Vol 12, Iss 6, p 777 (2023)

Subject Terms: breast cancer, gold nanoparticles, MMP-9, hsa-miR-204-5p, NF-κBp65, parthenolide, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/12/6/777; https://doaj.org/toc/2079-7737

Access URL: https://doaj.org/article/b7282b6fba7d41d68ee2400e84d277c3

Therapeutic Potential of Albumin Nanoparticles Encapsulated Visnagin in MDA-MB-468 Triple-Negative Breast Cancer Cells

Authors: Abdullah Alsrhani, Abozer Y. Elderdery, Badr Alzahrani, Nasser A. N. Alzerwi, Maryam Musleh Althobiti, Musaed Rayzah, Bandar Idrees, Ahmed M. E. Elkhalifa, Suresh K. Subbiah, Pooi Ling Mok

Source: Molecules, Vol 28, Iss 7, p 3228 (2023)

Subject Terms: breast cancer, albumin visnagin nanoparticles, MDA-MB-468 cell line, apoptosis, nanotechnology, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/7/3228; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/0974c03bdc8548e59f103c1bf3db45a2

Effects of Albumin–Chlorogenic Acid Nanoparticles on Apoptosis and PI3K/Akt/mTOR Pathway Inhibitory Activity in MDA-MB-435s Cells

Authors: Badr Alzahrani, Abozer Y. Elderdery, Abdullah Alsrhani, Nasser A. N. Alzerwi, Maryam Musleh Althobiti, Musaed Rayzah, Bandar Idrees, Ahmed M. E. Elkhalifa, Suresh K. Subbiah, Pooi Ling Mok

Source: Nanomaterials, Vol 13, Iss 9, p 1438 (2023)

Subject Terms: MDA-MB435s cells, albumin, chlorogenic acid, biogenic nanoparticles, apoptosis, anti-cancer, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/2079-4991/13/9/1438; https://doaj.org/toc/2079-4991

Access URL: https://doaj.org/article/678b8825291541c9873aa48a989a9779

Pluronic-F-127-Passivated SnO2 Nanoparticles Derived by Using Polygonum cuspidatum Root Extract: Synthesis, Characterization, and Anticancer Properties

Authors: Badr Alzahrani, Abozer Y. Elderdery, Nasser A. N. Alzerwi, Abdullah Alsrhani, Afnan Alsultan, Musaed Rayzah, Bandar Idrees, Fares Rayzah, Yaser Baksh, Ahmed M. Alzahrani, Suresh K. Subbiah, Pooi Ling Mok

Source: Plants, Vol 12, Iss 9, p 1760 (2023)

Subject Terms: pluronic F-127, tin oxide nanoparticles, anticancer, Polygonum cuspidatum root extract, HepG2 cancer cells, Botany, QK1-989

File Description: electronic resource

Relation: https://www.mdpi.com/2223-7747/12/9/1760; https://doaj.org/toc/2223-7747

Access URL: https://doaj.org/article/4b825ca743bd49c68a5b6387c5cd76ea

Trypsin induces an aversive response in zebrafish by PAR2 activation in keratinocytes.

Authors: Abdullah Alsrhani, Revathi Raman, Pudur Jagadeeswaran

Source: PLoS ONE, Vol 16, Iss 10, p e0257774 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9ce40942bc27466594acba483465c83f

Molecular analysis of blaSHV, blaTEM, and blaCTX-M in extended-spectrum β-lactamase producing Enterobacteriaceae recovered from fecal specimens of animals.

Authors: Hasan Ejaz, Sonia Younas, Khalid O A Abosalif, Kashaf Junaid, Badr Alzahrani, Abdullah Alsrhani, Abualgasim Elgaili Abdalla, Muhammad Ikram Ullah, Muhammad Usman Qamar, Sanaa S M Hamam

Source: PLoS ONE, Vol 16, Iss 1, p e0245126 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7f9ffe5023144a449c8ec1824aaa7039

Intraflagellar transport proteins are involved in thrombocyte filopodia formation and secretion

Authors: Uvaraj Radhakrishnan, Abdullah Alsrhani, Hemalatha Sundaramoorthi, Gauri Khandekar, Meghana Kashyap, Jannon L Fuchs, Brian D Perkins, Yoshihiro Omori, Pudur Jagadeeswaran

Source: Platelets, Vol 29, Iss 8, Pp 811-820 (2018)

Subject Terms: zebrafish, thrombocytes, intraflagellar transport, ift122, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/32f67f3e8188476f934846ea19006cb3

Camptothecin Encapsulated in β-Cyclodextrin-EDTA-Fe3O4 Nanoparticles Induce Metabolic Reprogramming Repair in HT29 Cancer Cells through Epigenetic Modulation: A Bioinformatics Approach

Authors: Aisha Farhana, Avin Ee-Hwan Koh, Pooi Ling Mok, Abdullah Alsrhani, Yusuf Saleem Khan, Suresh Kumar Subbiah

Source: Nanomaterials, Vol 11, Iss 12, p 3163 (2021)

Subject Terms: metabolic reprogramming, epigenetic modulation, colon cancer, nanoparticles, transcriptome analysis, Chemistry, QD1-999

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Relation: https://www.mdpi.com/2079-4991/11/12/3163; https://doaj.org/toc/2079-4991

Access URL: https://doaj.org/article/d57d276f794f450fae21377ee0aa1163

Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells

Authors: Aisha Farhana, Avin Ee-Hwan Koh, Jia Bei Tong, Abdullah Alsrhani, Suresh Kumar Subbiah, Pooi Ling Mok

Source: Molecules, Vol 26, Iss 17, p 5414 (2021)

Subject Terms: DNA repair, epigenetic modulation, colon cancer, nanoparticles, transcriptome analysis, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/17/5414; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/a445f1b46bd84e6aa2335068c01ae43d