A low-density DNA microchip for the detection of (anti-)estrogenic compounds and their relative potencies

Authors: Wang, Si, Rijk, Jeroen C.W., Pen, Marieke J., Aarts, Jac M.M.J.G., Peijnenburg, Ad A.C.M., Rietjens, Ivonne M.C.M., Bovee, Toine F.H.

Source: In Analytical Biochemistry 1 April 2013 435(1):83-92

Dual effects of N-acetyl-l-cysteine dependent on NQO1 activity: Suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity

Authors: Toyooka, Tatsushi, Shinmen, Takuya, Aarts, Jac M.M.J.G., Ibuki, Yuko

Source: In Toxicology and Applied Pharmacology 1 November 2012 264(3):404-412

Proliferation assays for estrogenicity testing with high predictive value for the in vivo uterotrophic effect

Authors: Wang, Si, Aarts, Jac M.M.J.G., Evers, Nynke M., Peijnenburg, Ad A.C.M., Rietjens, Ivonne M.C.M., Bovee, Toine F.H.

Source: In Journal of Steroid Biochemistry and Molecular Biology February 2012 128(3-5):98-106

Stable reporter cell lines for peroxisome proliferator-activated receptor γ (PPARγ)-mediated modulation of gene expression

Authors: Gijsbers, Linda, Man, Hai-Yen, Kloet, Samantha K., de Haan, Laura H.J., Keijer, Jaap, Rietjens, Ivonne M.C.M., van der Burg, Bart, Aarts, Jac M.M.J.G.

Source: In Analytical Biochemistry 2011 414(1):77-83

The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol

Authors: van Cruchten, Saskia T.J., de Haan, Laura H.J., Mulder, Patrick P.J., Kunne, Cindy, Boekschoten, Mark V., Katan, Martijn B., Aarts, Jac M.M.J.G., Witkamp, Renger F.

Source: In The Journal of Nutritional Biochemistry 2010 21(8):757-763

Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya

Authors: Vermeulen, Martijn, Boerboom, Anne-Marie M.J.F., Blankvoort, Barry M.G., Aarts, Jac M.M.J.G., Rietjens, Ivonne M.C.M., van Bladeren, Peter J., Vaes, Wouter H.J.

Source: In Toxicology in Vitro 2009 23(4):617-621

Shifted concentration dependency of EpRE- and XRE-mediated gene expression points at monofunctional EpRE-mediated induction by flavonoids at physiologically relevant concentrations

Authors: Lee-Hilz, Yee Y., ter Borg, Sovianne, van Berkel, Willem J.H., Rietjens, Ivonne M.C.M., Aarts, Jac M.M.J.G.

Source: In Toxicology in Vitro June 2008 22(4):921-926

Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation

Authors: Lee-Hilz, Yee Y., Stolaki, Maria, van Berkel, Willem J.H., Aarts, Jac M.M.J.G., Rietjens, Ivonne M.C.M.

Source: In Food and Chemical Toxicology June 2008 46(6):2128-2134

A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine

Authors: de Waard, Pim W.J., Peijnenburg, Ad A.C.M., Baykus, Hakan, Aarts, Jac M.M.J.G., Hoogenboom, Ron L.A.P., van Schooten, Frederik J., de Kok, Theo M.C.M.

Source: In Chemico-Biological Interactions 2008 176(1):19-29

In vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro

Authors: de Haan, Laura H.J., Pot, Gerda K., Aarts, Jac M.M.J.G., Rietjens, Ivonne M.C.M., Alink, Gerrit M.

Source: In Toxicology in Vitro 2006 20(5):594-600

Newly constructed stable reporter cell lines for mechanistic studies on electrophile-responsive element-mediated gene expression reveal a role for flavonoid planarity

Authors: Boerboom, Anne-Marie J.F., Vermeulen, Martijn, van der Woude, Hester, Bremer, Birgit I., Lee-Hilz, Yee Y., Kampman, Ellen, van Bladeren, Peter J., Rietjens, Ivonne M.C.M., Aarts, Jac M.M.J.G.

Source: In Biochemical Pharmacology 2006 72(2):217-226

Androgenic activity in surface water samples detected using the AR-LUX assay: indications for mixture effects

Authors: Blankvoort, Barry M.G., Rodenburg, Richard J.T., Murk, AlberTinka J., Koeman, Jan H., Schilt, Robert, Aarts, Jac M.M.J.G. ^*

Source: In Environmental Toxicology and Pharmacology 2005 19(2):263-272

Human NAD(P)H:Quinone oxidoreductase inhibition by flavonoids in living cells

Authors: Lee, Yee Y., Westphal, Adrie H., de Haan, Laura H.J., Aarts, Jac M.M.J.G., Rietjens, Ivonne M.C.M., van Berkel, Willem J.H.

Source: In Free Radical Biology and Medicine 2005 39(2):257-265

The role of quinone reductase (NQO1) and quinone chemistry in quercetin cytotoxicity

Authors: Gliszczyńska-Świgło, Anna, van der Woude, Hester, de Haan, Laura, Tyrakowska, Bożena, Aarts, Jac M.M.J.G, Rietjens, Ivonne M.C.M

Source: In Toxicology in Vitro 2003 17(4):423-431

A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells

Authors: De Haan, Laura H.J, Boerboom, Anne-Marie J.F, Rietjens, Ivonne M.C.M, van Capelle, Daniëlla, De Ruijter, Annemieke J.M, Jaiswal, Anil K, Aarts, Jac M.M.J.G

Source: In Biochemical Pharmacology 2002 64(11):1597-1603

Differential induction of electrophile-responsive element-regulated genes by n − 3 and n − 6 polyunsaturated fatty acids

Authors: van Beelen, Vincent A., Aarts, Jac M.M.J.G., Reus, Astrid, Mooibroek, Hans, Sijtsma, Lolke, Bosch, Dirk, Rietjens, Ivonne M.C.M., Alink, Gerrit M.

Source: In FEBS Letters 2006 580(19):4587-4590

From biofuel to bioproduct: is bioethanol a suitable fermentation feedstock for synthesis of bulk chemicals?

Authors: Weusthuis, Ruud A., Aarts, Jac M.M.J.G., Sanders, Johan P.M.

Source: Biofuels, Bioproducts & Biorefining; Sep/Oct2011, Vol. 5 Issue 5, p486-494, 9p

NQO1 and NFE2L2 polymorphisms, fruit and vegetable intake and smoking and the risk of colorectal adenomas in an endoscopy-based population.

Authors: Tijhuis, Mariken J., Visker, Marleen H.P.W., Aarts, Jac M.M.J.G., Laan, Wijnand, de Boer, Sybrand Y., Kok, Frans J., Kampman, Ellen

Source: International Journal of Cancer; Apr2008, Vol. 122 Issue 8, p1842-1848, 7p

Differential induction of electrophile-responsive element-regulated genes by n −3 and n −6 polyunsaturated fatty acids

Authors: van Beelen, Vincent A., Aarts, Jac M.M.J.G., Reus, Astrid, Mooibroek, Hans, Sijtsma, Lolke, Bosch, Dirk, Rietjens, Ivonne M.C.M., Alink, Gerrit M.

Source: FEBS Letters; Aug2006, Vol. 580 Issue 19, p4587-4590, 4p

Subject Terms: DOCOSAHEXAENOIC acid, OMEGA-3 fatty acids, ORGANOMETALLIC compounds, METALLOTHIONEIN

Comparison of Ah Receptor-Mediated Luciferase and Ethoxyresorufin-O-deethylase Induction in H4IIE Cells: Implications for Their Use as Bioanalytical Tools for the Detection of Polyhalogenated Aromatic Hydrocarbons

Authors: Sanderson, J.Thomas, Aarts, Jac M.M.J.G., Brouwer, Abraham, Froese, Kenneth L., Denison, Michael S., Giesy, John P.

Source: Toxicology and Applied Pharmacology; April 1996, Vol. 137 Issue: 2 p316-325, 10p