Uncovering the mechanism of Huangkui capsule in the treatment of diabetic kidney disease based on network pharmacology and experimental validation.

Authors: Liu, Junhong¹ (AUTHOR) 1069616768@qq.com, Li, Ziwei² (AUTHOR), Zhang, ZongYao³ (AUTHOR), Shen, Zhongyuan⁴ (AUTHOR)

Source: Scientific Reports. 2/22/2025, Vol. 15 Issue 1, p1-18. 18p.

Subject Terms: *DIABETIC nephropathies, *ANIMAL models of diabetes, *MOLECULAR dynamics, *MOLECULAR docking, *MOLECULAR capsules

Chondrosarcoma: New Molecular Insights, Challenges in Near-Patient Preclinical Modeling, and Therapeutic Approaches.

Authors: Landuzzi, Lorena¹ (AUTHOR) katia.scotlandi@ior.it, Ruzzi, Francesca² (AUTHOR), Lollini, Pier-Luigi^2,3 (AUTHOR) lorena.landuzzi@ior.it, Scotlandi, Katia¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1542. 25p.

Subject Terms: *OLDER people, *ANIMAL models in research, *OVERALL survival, *CHONDROSARCOMA, *PROGNOSIS

Evaluating the efficacy of vatiquinone in preclinical models of Leigh syndrome and GPX4 deficiency.

Authors: Kayser, Ernst-Bernhard¹ (AUTHOR), Mulholland, Michael² (AUTHOR), Olkhova, Elizaveta A.² (AUTHOR), Chen, Yihan¹ (AUTHOR), Coulson, Holly² (AUTHOR), Cairns, Owen² (AUTHOR), Truong, Vivian² (AUTHOR), James, Katerina^1,2 (AUTHOR), Johnson, Brittany M.² (AUTHOR), Hanaford, Allison¹ (AUTHOR), Johnson, Simon C.^1,2,3,4,5 (AUTHOR) simon.c.johnson@northumbria.ac.uk

Source: Orphanet Journal of Rare Diseases. 2/13/2025, Vol. 20 Issue 1, p1-16. 16p.

Subject Terms: *MITOCHONDRIAL pathology, *ANIMAL models in research, *TREATMENT effectiveness, *CELL death, *ANTIOXIDANTS, *MITOCHONDRIAL DNA abnormalities

The Oikawa-Nagao Mouse: A Polygenic Animal Model for Unraveling the Pathophysiology of Type 2 Diabetes and Obesity.

Authors: Mototsugu Nagao¹ s8067@nms.ac.jp, Shinichi Oikawa^1,2

Source: Journal of Nippon Medical School. Feb2025, Vol. 92 Issue 1, p2-9. 8p.

Subject Terms: *ANIMAL models of diabetes, *LIFE sciences, *DIABETIC angiopathies, *TRANSCRIPTION factors, *FORKHEAD transcription factors, *LEPTIN

Enhancing dermal collagen density towards youthfulness: A comparative study of PCL, PLLA, and PDO thread implantation in aging rats model.

Authors: Soen, Mary¹ marysoen86@gmail.com, Hidayat, Meilinah², Widowati, Wahyu³

Source: Iranian Journal of Basic Medical Sciences. Feb2025, Vol. 28 Issue 2, p151-157. 7p.

Subject Terms: *ANIMAL models for aging, *SKIN aging, *FACELIFT, *RATTUS norvegicus, *SKIN biopsy

The Progress in Treatment of β-Thalassemia and Research on Animal Models of the Disease.

Authors: Zhang, Shumeng¹, z19937166283@163.com, Dong, Zexia¹, Yan, Wenhao¹, Wang, Wenjing¹, Pei, Yangli¹, Feng, Zheng¹, greatfz@126.com

Source: Applied Sciences (2076-3417); Feb2025, Vol. 15 Issue 3, p1661, 11p

Anti-oxidation enhancement, inflammation alleviation, and microbial composition optimization of using tussah (Antheraea pernyi) silk fibroin peptides for hyperglycaemia remission.

Authors: Mi, Rui¹ (AUTHOR), Li, Xuejun¹ (AUTHOR), Li, Yajie¹ (AUTHOR), Du, Xingfan¹ (AUTHOR) lnnky_dl@163.com

Source: PLoS ONE. 1/23/2025, Vol. 19 Issue 1, p1-21. 21p.

Subject Terms: *ANIMAL models of diabetes, *GUT microbiome, *PATHOGENIC bacteria, *BLOOD sugar, *SILK fibroin

Preclinical Testing Strategies for Epilepsy Therapy Development.

Authors: Riley, Victoria A.^1,2 (AUTHOR), Danzer, Steve C.^1,2,3 (AUTHOR) steve.danzer@cchmc.org

Source: Epilepsy Currents. Jan/Feb2025, Vol. 25 Issue 1, p51-57. 7p.

Subject Terms: *EPILEPSY, *ANIMAL models in research, *ANIMAL experimentation, *MEDICAL protocols, *THERAPEUTICS

Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of Centella asiatica.

Authors: Chamberlin, Steven R.^1,2,3 (AUTHOR) chambest@ohsu.edu, Zweig, Jonathan A.^2,3 (AUTHOR) claudia.maier@oregonstate.edu, Neff, Cody J.^2,3 (AUTHOR), Marney, Luke^3,4 (AUTHOR), Choi, Jaewoo^3,4 (AUTHOR), Yang, Liping^3,4 (AUTHOR), Maier, Claudia S.^3,4 (AUTHOR), Soumyanath, Amala^2,3 (AUTHOR), McWeeney, Shannon^1,5 (AUTHOR), Gray, Nora E.^2,3 (AUTHOR)

Source: Pharmaceuticals (14248247). Jan2025, Vol. 18 Issue 1, p19. 24p.

Subject Terms: *ANIMAL models for aging, *GENE expression, *GENE regulatory networks, *CENTELLA asiatica, *ALZHEIMER'S disease, *METABOLOMICS

Antidiabetic Effects of Coffee Enriched with Maca and Marine Collagen Peptide (Blackbelt®) in a Type 2 Diabetes Mellitus Rat Model.

Authors: N. H., Othman¹, H. R., Ismawi¹ hidayatulradziah@iium.edu.my, M., Mohd Zainudin¹, A., Abd Fuaat²

Source: IIUM Medical Journal Malaysia. Jan2025, Vol. 24 Issue 1, p94-104. 11p.

Subject Terms: *ANIMAL models of diabetes, *TYPE 2 diabetes, *LABORATORY rats, *INSULIN sensitivity, *PEPTIDES

Applying an Untargeted Metabolomic Strategy to Explore the Interventional Effect and Mechanism of NMN on Aging Model Mice.

Authors: Lin, Yuxian^1,2 (AUTHOR), Wu, Yan² (AUTHOR), Zhu, Yuanying² (AUTHOR), Luo, Ting² (AUTHOR), Sun, Zheng² (AUTHOR), Liu, Xuecun² (AUTHOR), Yu, Yingcong¹ (AUTHOR) yuyingcong001@126.com, Xu, Hui² (AUTHOR) xuhui33@sina.com, Cruz, Rui M. S. (AUTHOR)

Source: Journal of Food Biochemistry. 11/21/2024, Vol. 2024, p1-11. 11p.

Subject Terms: Animal models for aging, Oral drug administration, Lipid metabolism, Metabolomics, Nicotinamide, NAD (Coenzyme)

Animal Models of Human Disease 2.0.

Authors: Lange, Sigrun¹ (AUTHOR) s.lange@westminster.ac.uk, Inal, Jameel M.^2,3 (AUTHOR) j.inal@londonmet.ac.uk

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13743. 9p.

Subject Terms: *LABORATORY rats, *ANIMAL models in research, *ANIMAL disease models, *STEM cell research, *INDUCED pluripotent stem cells, *BRACHYDANIO, *RATS, *LUNGS

Centella asiatica Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis.

Authors: Kundu, Payel¹ (AUTHOR), Yasuhara, Kanon² (AUTHOR), Brandes, Mikah S.^3,4 (AUTHOR), Zweig, Jonathan A.³ (AUTHOR), Neff, Cody J.^3,4 (AUTHOR), Holden, Sarah¹ (AUTHOR), Kessler, Kat¹ (AUTHOR), Matsumoto, Steven⁵ (AUTHOR), Offner, Halina^3,6,7 (AUTHOR), Waslo, Carin S.⁶ (AUTHOR), Vandenbark, Arthur^3,6,8 (AUTHOR), Soumyanath, Amala^3,4 (AUTHOR), Sherman, Larry S.^2,9 (AUTHOR), Raber, Jacob^1,2,3,4,10 (AUTHOR), Gray, Nora E.^3,4 (AUTHOR), Spain, Rebecca I.^3,6 (AUTHOR) spainr@ohsu.edu

Source: Pharmaceuticals (14248247). Dec2024, Vol. 17 Issue 12, p1681. 14p.

Subject Terms: *ANIMAL models for aging, *CENTELLA asiatica, *MEDICAL botany, *LABORATORY mice, *MULTIPLE sclerosis

Antidiabetic medicinal plants from the Chenopodiaceae family: a comprehensive overview.

Authors: Cherrada, Nezar^1,2 (AUTHOR), Elkhalifa Chemsa, Ahmed^2,3 (AUTHOR), Gheraissa, Noura^3,4 (AUTHOR), Zaater, Abdelmalek^2,5 (AUTHOR), Benamor, Bilal^4,6 (AUTHOR), Ghania, Ahmed^1,7 (AUTHOR), Yassine, Bouras^1,7 (AUTHOR), Kaddour, Abdelbasset³ (AUTHOR), Afzaal, Muhammad⁸ (AUTHOR) muhammadafzaal@gcuf.edu.pk, Asghar, Aasma⁹ (AUTHOR), Saeed, Farhan⁸ (AUTHOR), Teferi Asres, Degnet¹⁰ (AUTHOR)

Source: International Journal of Food Properties. 2024, Vol. 27 Issue 1, p194-213. 20p.

Subject Terms: *ANIMAL models of diabetes, *BLOOD sugar, *MEDICINAL plants, *BIOACTIVE compounds, *CHENOPODIACEAE, *INSULIN

Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.

Authors: Xi, Huaming¹ (AUTHOR), Chen, Xinyu¹ (AUTHOR), Liang, Kai¹ (AUTHOR) xihuaming@zafu.edu.cn, Wang, Xianglong¹ (AUTHOR), Jiang, Feng¹ (AUTHOR), Li, Yuan¹ (AUTHOR) liyuan@zafu.edu.cn, Niu, Dong¹ (AUTHOR) liyuan@zafu.edu.cn

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 23, p12643. 14p.

Subject Terms: *GRANULOSA cells, *ANIMAL models for aging, *CELLULAR aging, *TREHALOSE, *OVARIES

Adenine-induced animal model of chronic kidney disease: current applications and future perspectives.

Authors: Yang, Qiao¹ (AUTHOR), Su, Songya¹ (AUTHOR), Luo, Nan¹ (AUTHOR), Cao, Gang¹ (AUTHOR) caogang33@163.com

Source: Renal Failure. Dec2024, Vol. 46 Issue 2, p1-20. 20p.

Subject Terms: *CHRONIC kidney failure, *ANIMAL models in research, *KIDNEY diseases, *THERAPEUTICS, *METABOLIC disorders

Simultaneous, Non-Contact and Motion-Based Monitoring of Respiratory Rate in Sheep Under Experimental Condition Using Visible and Near-Infrared Videos.

Authors: Bonafini, Beatriz Leandro¹ (AUTHOR) beatriz.bonafini@pucpr.edu.br, Breuer, Lukas² (AUTHOR) lubreuer@ukaachen.de, Ernst, Lisa³ (AUTHOR) lernst@ukaachen.de, Tolba, René³ (AUTHOR) rtolba@ukaachen.de, Oliveira, Lucas Ferrari de⁴ (AUTHOR) lferrari@inf.ufpr.br, Abreu de Souza, Mauren¹ (AUTHOR), Czaplik, Michael² (AUTHOR) mczaplik@ukaachen.de, Pereira, Carina Barbosa² (AUTHOR) cbarbosapere@ukaachen.de

Source: Animals (2076-2615). Dec2024, Vol. 14 Issue 23, p3398. 19p.

Subject Terms: *VIDEO processing, *ANIMAL models in research, *ANIMAL welfare, *VENTILATION monitoring, *ANIMAL experimentation

Oxidative Stress and Histomorphometric Remodeling: Two Key Intestinal Features of Type 2 Diabetes in Goto–Kakizaki Rats.

Authors: Esteves-Monteiro, Marisa^1,2,3 (AUTHOR) mmem89@gmail.com, Ferreira-Duarte, Mariana^1,3 (AUTHOR), Vitorino-Oliveira, Cláudia^4,5 (AUTHOR) veramcosta@ff.up.pt, Costa-Pires, José² (AUTHOR), Oliveira, Sara^6,7,8 (AUTHOR) saraoliveira116@gmail.com, Matafome, Paulo^6,7,8,9 (AUTHOR), Morato, Manuela^1,3 (AUTHOR), Dias-Pereira, Patrícia¹⁰ (AUTHOR) pdiaspereira@yahoo.com.br, Costa, Vera Marisa^4,5 (AUTHOR), Duarte-Araújo, Margarida^1,2 (AUTHOR) mmem89@gmail.com

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12115. 18p.

Subject Terms: *ANIMAL models of diabetes, *TYPE 2 diabetes, *DIABETES complications, *SMOOTH muscle, *OXIDATIVE stress

Occurrence and Genotypic Identification of Blastocystis spp. and Enterocytozoon bieneusi in Bamaxiang Pigs in Bama Yao Autonomous County of Guangxi Province, China.

Authors: Yu, Xingang¹ (AUTHOR) yuxingang4525@163.com, Mu, Xuanru¹ (AUTHOR) 15940815092@163.com, Yuan, Kaijian¹ (AUTHOR) yuankj0195@163.com, Wang, Sifan¹ (AUTHOR) 20230420301@stu.fosu.edu.cn, Li, Yilong¹ (AUTHOR) muylyl20001110@163.com, Xu, Hui¹ (AUTHOR) 2112359031@stu.fosu.edu.cn, Li, Qiaoyu¹ (AUTHOR) 2112459167@stu.fosu.edu.cn, Zeng, Wenjing¹ (AUTHOR) 2112459159@stu.fosu.edu.cn, Li, Zhili¹ (AUTHOR) pinganzhili@163.com, Guo, Jianchao² (AUTHOR) jianchaoguo000@163.com, Hong, Yang^3,4 (AUTHOR) jianchaoguo000@163.com

Source: Animals (2076-2615). Nov2024, Vol. 14 Issue 22, p3344. 12p.

Subject Terms: *ENTEROCYTOZOON bieneusi, *ANIMAL models in research, *ZOONOSES, *PARASITIC diseases, *RIBOSOMAL RNA, *SWINE farms

The Influence of Atorvastatin Treatment on Homocysteine Metabolism and Oxidative Stress in an Experimental Model of Diabetic Rats.

Authors: Clim, Andreea¹ (AUTHOR) clim.andreea@umfiasi.ro, Maranduca, Minela Aida^1,2 (AUTHOR) floria.mariana@umfiasi.ro, Filip, Nina³ (AUTHOR) nina.zamosteanu@umfiasi.ro, Tănase, Daniela Maria^2,4 (AUTHOR) nina.zamosteanu@umfiasi.ro, Floria, Mariana^2,4 (AUTHOR), Pinzariu, Alin Constantin¹ (AUTHOR) alin.pinzariu@umfiasi.ro, Popa, Irene Paula^1,5 (AUTHOR) irene-paula_popa@umfiasi.ro, Nemteanu, Roxana^6,7 (AUTHOR) roxana.maxim@umfiasi.ro, Cozma, Tudor Cristian¹ (AUTHOR) cozmatudor19@gmail.com, Faur, Flaviu Ionut^8,9,10 (AUTHOR) flaviu.faur@umft.ro, Serban, Dragomir Nicolae¹ (AUTHOR) dragomir.serban@umfiasi.ro, Scripcariu, Dragoș Viorel^11,12 (AUTHOR), Serban, Ionela Lacramioara¹ (AUTHOR) ionela.serban@umfiasi.ro

Source: Life (2075-1729). Nov2024, Vol. 14 Issue 11, p1414. 18p.

Subject Terms: *ANIMAL models of diabetes, *MAJOR adverse cardiovascular events, *TYPE 2 diabetes, *OXIDANT status, *STATINS (Cardiovascular agents)