AL Amyloidosis: Current Treatment and Outcomes.

Authors: Locke, Margaret¹ (AUTHOR), Nieto, Maria¹ (AUTHOR) mnieto2@northwell.edu, Rice, Lawrence¹ (AUTHOR)

Source: Advances in Hematology. 3/3/2025, Vol. 2025, p1-6. 6p.

Subject Terms: *STEM cell transplantation, *AMYLOIDOSIS treatment, *AMYLOIDOSIS diagnosis, *THERAPEUTIC use of monoclonal antibodies, *COMBINATION drug therapy, *BIOPSY, *T cells, *AMYLOIDOSIS, *TREATMENT effectiveness, *BORTEZOMIB, *DISEASE relapse, *PROGRESSION-free survival, *CYCLOPHOSPHAMIDE, *DEXAMETHASONE, *OVERALL survival, *DISEASE risk factors

Clinical features of hereditary transthyretin amyloidosis-polyneuropathy with transthyretin Ala97Ser(p.Ala117Ser) mutation in South Mainland China.

Authors: Zhu, Yeli¹ (AUTHOR), Fan, Jingxian¹ (AUTHOR), Zhu, Xiying² (AUTHOR), Li, Wei¹ (AUTHOR), Zhang, Zhaoyong¹ (AUTHOR), Zheng, Hui¹ (AUTHOR), Zhou, Zhihua³ (AUTHOR), Meng, Lingchao⁴ (AUTHOR) lcmeng@bjmu.edu.cn, Zhang, Ruxu² (AUTHOR) zhangruxu@vip.163.com, Jiang, Haishan¹ (AUTHOR) jianghs@smu.edu.cn

Source: Orphanet Journal of Rare Diseases. 4/28/2025, Vol. 20 Issue 1, p1-10. 10p.

Subject Terms: *AMYLOIDOSIS, *GENETIC mutation, *EPIDEMIOLOGY, *DYSAUTONOMIA, *POLYNEUROPATHIES, *NERVE conduction studies, *SYMPTOMS

Geographic Terms: CHINA

Integrated specialty care for amyloidosis: a scoping review using the Consolidated Framework for Implementation Research.

Authors: O'Sullivan, Mary¹ (AUTHOR) mary.osullivan@mail.utoronto.ca, Osman, Wahab^1,2 (AUTHOR) wahab.osman@utoronto.ca, Krisnagopal, Archanaa¹ (AUTHOR) archanaa.krisnagopal@mail.utoronto.ca, Parry, Monica¹ (AUTHOR) monica.parry@utoronto.ca, Davis, Margot^3,4 (AUTHOR) margot.davis@ubc.ca, Chu, Charlene H.^1,5,6 (AUTHOR) Charlene.chu@utoronto.ca

Source: BMC Health Services Research. 3/21/2025, Vol. 25 Issue 1, p1-15. 15p.

Subject Terms: *CARDIAC amyloidosis, *PATIENT advocacy, *MEDICAL sciences, *GREY literature, *EVIDENCE gaps

Diagnosis of hereditary transthyretin amyloidosis in patients with suspected chronic inflammatory demyelinating polyneuropathy unresponsive to intravenous immunoglobulins: results of a retrospective study.

Authors: Péréon, Yann¹ (AUTHOR) yann.pereon@univ-nantes.fr, Adams, David² (AUTHOR), Camdessanché, Jean-Philippe³ (AUTHOR), Chanson, Jean-Baptiste⁴ (AUTHOR), Cintas, Pascal⁵ (AUTHOR), Magy, Laurent⁶ (AUTHOR), Signaté, Aïssatou⁷ (AUTHOR), Solé, Guilhem⁸ (AUTHOR), Svahn, Juliette⁹ (AUTHOR), Tard, Céline¹⁰ (AUTHOR), Hababou, Cyrla¹¹ (AUTHOR), Attarian, Shahram¹² (AUTHOR)

Source: Orphanet Journal of Rare Diseases. 3/1/2025, Vol. 20 Issue 1, p1-7. 7p.

Subject Terms: *CHRONIC inflammatory demyelinating polyradiculoneuropathy, *AMYLOIDOSIS, *MEDICAL personnel, *RETROSPECTIVE studies, *SYMPTOMS, *TRANSTHYRETIN, *DIAGNOSIS methods

Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis.

Authors: Bézard, Mélanie^1,2 (AUTHOR), Vartanian-Grimaldi, Jean-Sébastien¹ (AUTHOR), Henri, Julien³ (AUTHOR), Calin, Denisa¹ (AUTHOR), Zaroui, Amira² (AUTHOR), Kharoubi, Mounira² (AUTHOR), Damy, Thibaud² (AUTHOR), Agbulut, Onnik¹ (AUTHOR) onnik.agbulut@sorbonne-universite.fr, Kordeli, Ekaterini¹ (AUTHOR) ekaterini.kordeli@inserm.fr

Source: Scientific Reports. 2/4/2025, Vol. 15 Issue 1, p1-10. 10p.

Subject Terms: *IMMUNOGLOBULIN light chains, *CARDIAC amyloidosis, *CYTOTOXINS, *MEDICAL model, *AMYLOID, *PLURIPOTENT stem cells, *AMYLOIDOSIS

Future Directions in Quantitative SPECT-CT Evaluation of Cardiac Transthyretin Amyloidosis: Correlation with Clinical and Morphological Parameters.

Authors: Gherghe, Mirela^1,2 (AUTHOR) tatiana.stl07@yahoo.com, Mutuleanu, Mario-Demian^1,2 (AUTHOR) mario-demian.mutuleanu@drd.umfcd.ro, Suta, Tatiana Lucia² (AUTHOR) mario-demian.mutuleanu@drd.umfcd.ro, Micu, Liliana² (AUTHOR), Stanciu, Adina Elena³ (AUTHOR), Ionescu, Sinziana-Octavia^4,5 (AUTHOR), Cirimbei, Ciprian^4,5 (AUTHOR), Paun, Diana Loreta^6,7 (AUTHOR), Jercan, Andreea⁸ (AUTHOR), Badelita, Sorina Nicoleta⁸ (AUTHOR), Coriu, Daniel^8,9 (AUTHOR)

Source: Diagnostics (2075-4418). Feb2025, Vol. 15 Issue 4, p482. 16p.

Subject Terms: *CARDIAC amyloidosis, *RADIONUCLIDE imaging, *VENTRICULAR ejection fraction, *HEART failure, *EARLY diagnosis

Integrated Clinomics and Molecular Dynamics Simulation Approaches Reveal the SAA1.1 Allele as a Biomarker in Alkaptonuria Disease Severity.

Authors: Trezza, Alfonso¹ (AUTHOR) alfonso.trezza2@unisi.it, Roncaglia, Bianca¹ (AUTHOR) bianca.roncaglia@unisi.it, Visibelli, Anna¹ (AUTHOR) anna.visibelli2@unisi.it, Barletta, Roberta¹ (AUTHOR) r.barletta@student.unisi.it, Peruzzi, Luana¹ (AUTHOR) luana.peruzzi@unisi.it, Marzocchi, Barbara¹ (AUTHOR) barbara.marzocchi@unisi.it, Braconi, Daniela¹ (AUTHOR) daniela.braconi@unisi.it, Spiga, Ottavia¹ (AUTHOR) ottavia.spiga@unisi.it, Santucci, Annalisa^1,2 (AUTHOR) annalisa.santucci@unisi.it

Source: Biomolecules (2218-273X). Feb2025, Vol. 15 Issue 2, p194. 16p.

Subject Terms: *AMYLOID beta-protein, *AMYLOIDOSIS, *STRUCTURAL dynamics, *INFLAMMATORY mediators, *DATA integration, *MOLECULAR dynamics

Improving prognostic evaluations in patients with stage IIIb light chain cardiac amyloidosis: role of haemodynamic parameters.

Authors: Li, Jingyi¹ (AUTHOR), Lu, Yang¹ (AUTHOR), Xu, Xiqi¹ (AUTHOR), Tian, Zhuang¹ (AUTHOR) tianzhuangcn@sina.com, Li, Jian² (AUTHOR) lijian@pumch.cn, Zhang, Shuyang¹ (AUTHOR) zhangshuyang2018@126.com

Source: Orphanet Journal of Rare Diseases. 1/13/2025, Vol. 20 Issue 1, p1-8. 8p.

Subject Terms: *RECEIVER operating characteristic curves, *CARDIAC amyloidosis, *VASCULAR resistance, *PULMONARY artery, *SYSTOLIC blood pressure, *SURVIVAL analysis (Biometry)

Does the presence of high levels of free Sn²⁺ in PYP kit cause in vivo red blood cell radiolabeling and high blood pool radioactivity?

Authors: Hedayati, Raheleh¹, Hazini, Negar², Hassanzadeh, Leila^2,3 hassanzadeh.l@iums.ac.ir

Source: Iranian Journal of Nuclear Medicine. Jan2025, Vol. 33 Issue 1, p37-45. 9p.

Subject Terms: *CARDIAC amyloidosis, *ERYTHROCYTES, *RADIOACTIVITY, *KIDNEY physiology, *TRANSTHYRETIN

What is New in Multiple Endocrine Neoplasia Type 2?

Authors: Çakır, Mehtap¹ mehtapcakir@gmail.com

Source: Endocrinology Research & Practice. Jan2025, Vol. 29 Issue 1, p59-68. 10p.

Subject Terms: *HYPERPARATHYROIDISM, *AMYLOIDOSIS, *GENE expression, *HIRSCHSPRUNG'S disease, *GENETIC mutation, *SIPPLE syndrome, *GENOTYPES, *PHENOTYPES, *PHEOCHROMOCYTOMA, *DISEASE risk factors

Multiple Red Flags of Cardiac Amyloidosis in a Single Patient: Clinical Manifestations of an Underdiagnosed Disease.

Authors: Dąbrowski, Emil Julian¹ (AUTHOR) emil.dabrowski@sd.umb.edu.pl, Kozłowska, Wiktoria Urszula¹ (AUTHOR), Lipska, Patrycja Oliwia¹ (AUTHOR), Matys, Urszula¹ (AUTHOR), Pogorzelski, Szymon¹ (AUTHOR), Kożuch, Marcin¹ (AUTHOR), Dobrzycki, Sławomir¹ (AUTHOR)

Source: Diagnostics (2075-4418). Dec2024, Vol. 14 Issue 24, p2812. 4p.

Subject Terms: *CARDIAC amyloidosis, *SYMPTOMS, *HEART failure, *HYPERTROPHIC cardiomyopathy, *TERTIARY structure

A Comprehensive Review of Cardiac Amyloidosis: Advances in Diagnosis, Clinical Manifestations and Therapeutic Strategies.

Authors: Agayeva, Gulana¹ doctorgulane@yahoo.com, Islamova, Narmin¹

Source: Systematic Reviews in Pharmacy. Dec2024/Jan2025, Vol. 15 Issue 12, p369-372. 4p.

Subject Terms: *CARDIAC magnetic resonance imaging, *CARDIAC amyloidosis, *STEM cell transplantation, *SYMPTOMS, *HEART failure

The Transthyretin Protein and Amyloidosis – An Extraordinary Chemical Biology Platform.

Authors: Hammarström, Per¹ (AUTHOR) per.hammarstrom@liu.se

Source: Israel Journal of Chemistry. Dec2024, Vol. 64 Issue 12, p1-12. 12p.

Subject Terms: *TRANSTHYRETIN, *AMYLOIDOSIS, *TRANSLATIONAL research, *AMYLOID beta-protein, *THERAPEUTICS, *DENATURATION of proteins, *ETIOLOGY of diseases, *CHEMICAL biology

Understanding and Overcoming Biochemical Diversity in AL Amyloidosis.

Authors: Morgan, Gareth J.¹ (AUTHOR) gjmorgan@bu.edu

Source: Israel Journal of Chemistry. Dec2024, Vol. 64 Issue 12, p1-15. 15p.

Subject Terms: *AMYLOIDOSIS, *IMMUNOGLOBULIN light chains, *AMYLOID, *AMYLOID plaque, *DENATURATION of proteins, *BIOCHEMICAL variation, *DRUG discovery, *INVESTIGATIONAL therapies

Histopathological and Immunohistochemical Characteristics of Different Types of Cardiac Amyloidosis.

Authors: Gioeva, Zarina V.¹ (AUTHOR) gioeva_z@mail.ru, Mikhaleva, Liudmila M.¹ (AUTHOR) gyt94@yandex.ru, Gutyrchik, Nikita A.^1,2 (AUTHOR) alex.volkoff@gmail.com, Volkov, Alexey V.^1,2 (AUTHOR) nshakhpazyan@gmail.com, Popov, Mikhail A.³ (AUTHOR) popovcardio88@mail.ru, Shakhpazyan, Nikolay K.¹ (AUTHOR) valiagtx@yandex.ru, Pechnikova, Valentina V.¹ (AUTHOR) midiberkonst@gmail.com, Midiber, Konstantin Y.^1,2 (AUTHOR) levkaktur@mail.ru, Reznik, Elena V.⁴ (AUTHOR) elenaresnik@gmail.com, Kakturskij, Lev V.¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10667. 15p.

Subject Terms: *IMMUNOGLOBULIN light chains, *CARDIAC amyloidosis, *AMYLOID plaque, *HEART failure patients, *AMYLOIDOSIS, *AUTOPSY

Systemic amyloidosis following inflammatory bowel disease, follicular lymphoma, and diffuse large B-cell lymphoma: a case report.

Authors: Sukrisman, Lugyanti¹ lugyanti@gmail.com, Makmun, Dadang¹, Krisnuhoni, Ening²

Source: Medical Journal of Indonesia. Sep2024, Vol. 33 Issue 3, p198-202. 5p.

Subject Terms: *AMYLOIDOSIS diagnosis, *NON-Hodgkin's lymphoma, *CARDIAC amyloidosis, *MULTIPLE organ failure, *AMYLOIDOSIS, *RITUXIMAB, *TREATMENT effectiveness, *INFLAMMATORY bowel diseases, *BUTYRIC acid, *KIDNEY diseases, *B cell lymphoma, *GASTROINTESTINAL diseases, *DISEASE complications

Doxycycline Plus Bortezomib-Containing Regimens for the Treatment of Light-Chain Amyloidosis in the Frontline Setting: Experience from the Amyloidosis Program of Calgary.

Authors: Lewis, Ellen¹ (AUTHOR) ellen.lewis@ahs.ca, Fine, Nowell² (AUTHOR) nowell.fine@ahs.ca, McCulloch, Sylvia¹ (AUTHOR) sylvia.mcculloch@ahs.ca, Tay, Jason^1,3 (AUTHOR) jason.tay@ahs.ca, Duggan, Peter^1,3 (AUTHOR) peter.duggan@ahs.ca, Neri, Paola^1,3 (AUTHOR) epneri@ucalgary.ca, Bahlis, Nizar^1,3 (AUTHOR) nbahlis@ucalgary.ca, Jimenez-Zepeda, Victor H.^1,3 (AUTHOR) victor.zepeda@albertahealthservices.ca

Source: Current Oncology. Sep2024, Vol. 31 Issue 9, p5608-5616. 9p.

Subject Terms: *PROGRESSION-free survival, *AMYLOIDOSIS, *CARDIAC patients, *DOXYCYCLINE, *CARDIAC amyloidosis, *BORTEZOMIB

Diagnostic and therapeutic challenges in rapidly progressing cardiac amyloidosis: a literature review based on case report.

Authors: Senobari, Nahid¹ (AUTHOR), Nazari, Roozbeh¹ (AUTHOR), Ebrahimi, Pouya² (AUTHOR) Pouyaebrahimi1992@gmail.com, Soleimani, Hamidreza² (AUTHOR), Taheri, Maryam² (AUTHOR), Hosseini, Kaveh² (AUTHOR), Taheri, Homa³ (AUTHOR), Siegel, Robert J.³ (AUTHOR)

Source: International Journal of Emergency Medicine. 10/21/2024, Vol. 17 Issue 1, p1-12. 12p.

Subject Terms: *CARDIAC amyloidosis, *TREATMENT effectiveness, *MAGNETIC resonance imaging, *HEART failure, *ELECTROCARDIOGRAPHY, *EARLY diagnosis, *DYSPNEA, *DISEASE progression, *CARDIAC surgery

A series of cases of transthyretin amyloid cardiomyopathy with negative bone scintigraphy but a confirmed positive endomyocardial biopsy.

Authors: Fraix, Antoine¹ (AUTHOR) antoine.fraix@gmail.com, Itti, Emmanuel^2,3,4,5 (AUTHOR), Zaroui, Amira⁶ (AUTHOR), Kharoubi, Mounira^3,4,5,6,7 (AUTHOR), Poullot, Elsa^3,8 (AUTHOR), Lerman, Lionel^2,3,4 (AUTHOR), Guendouz, Soulef^3,4,5,6,7 (AUTHOR), Huttin, Olivier¹ (AUTHOR), Damy, Thibaud^3,4,5,6,7 (AUTHOR), Galat, Arnault^3,4,5,6,7 (AUTHOR)

Source: Orphanet Journal of Rare Diseases. 10/15/2024, Vol. 19 Issue 1, p1-10. 10p.

Subject Terms: *RADIONUCLIDE imaging, *CARDIAC amyloidosis, *SYMPTOMS, *DIAGNOSTIC imaging, *DIAGNOSIS methods

Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43.

Authors: Jianxing Song¹ dbssjx@nus.edu.sg

Source: Aging & Disease. Oct2024, Vol. 15 Issue 5, p2084-2112. 29p.

Subject Terms: *PHASE separation, *AMYLOIDOSIS, *MICRORNA