Deciphering glial contributions to CSF1R-related disorder via single-nuclear transcriptomic profiling: a case study

Authors: Jie Pan, Jaume Fores-Martos, Claire Delpirou Nouh, Tanner D. Jensen, Kristen Vallejo, Romain Cayrol, Saman Ahmadian, Euan A. Ashley, Michael D. Greicius, Inma Cobos

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-21 (2024)

Subject Terms: ALSP, HDLS, CSF1R, Microglia, Macrophage, Oligodendrocyte, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/274c1c8cf2c746b398593b20211d6b78

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

Authors: Marie-France Dorion, Diana Casas, Irina Shlaifer, Moein Yaqubi, Peter Fleming, Nathan Karpilovsky, Carol X.-Q. Chen, Michael Nicouleau, Valerio E. C. Piscopo, Emma J. MacDougall, Aeshah Alluli, Taylor M. Goldsmith, Alexandria Schneider, Samuel Dorion, Nathalia Aprahamian, Adam MacDonald, Rhalena A. Thomas, Roy W. R. Dudley, Jeffrey A. Hall, Edward A. Fon, Jack P. Antel, Jo Anne Stratton, Thomas M. Durcan, Roberta La Piana, Luke M. Healy

Source: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)

Subject Terms: Microglia, iPSC, ALSP, CSF1R, Inflammation, Phagocytosis, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/aa6be16cdc4045c0b1747096bb52aa8a

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Estimation of pathological lesion stage from brain images

Authors: Kinoshita, Michiaki ^a, Oyanagi, Kiyomitsu ^{b, ⁎}, Matsushima, Akira ^{c, d}, Kondo, Yasufumi ^c, Hirano, Shigeki ^e, Ishizawa, Keisuke ^f, Ishihara, Kenji ^g, Terada, Seishi ^h, Inoue, Teruhiko ⁱ, Yazawa, Ikuru ^j, Washimi, Yukihiko ^k, Yamada, Mitsunori ^b, Nakayama, Jun ^{l, 1}, Mitsuyama, Yoshio ⁱ, Ikeda, Shu-ichi ^c, Sekijima, Yoshiki ^c

Source: In Journal of the Neurological Sciences 15 June 2024 461

Clinical presentation and diagnosis of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia: a literature analysis of case studies

Authors: Spyros Papapetropoulos, Jeffrey M. Gelfand, Takuya Konno, Takeshi Ikeuchi, Angela Pontius, Andreas Meier, Farid Foroutan, Zbigniew K. Wszolek

Source: Frontiers in Neurology, Vol 15 (2024)

Subject Terms: adult-onset leukoencephalopathy with axonal spheroids and pigmented glia, ALSP, CSF1R-related leukoencephalopathy, diagnosis, misdiagnosis, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2024.1320663/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/30d07e6c04e94587ada8f8ca4b073be4

Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Authors: Xin Li, Banglian Hu, Xiaoyan Guan, Ziwei Wang, Yuhang Zhou, Hao Sun, Xian Zhang, Yanfang Li, Xiaohua Huang, Yingjun Zhao, Xin Wang, Huaxi Xu, Yun-Wu Zhang, Zhanxiang Wang, Honghua Zheng

Source: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)

Subject Terms: CSF1R, Microglia, Microgliopathy, Minocycline, ALSP, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/59f57c62a5e446e6833d9f2762df993b

Case report: Treatment of advanced CSF1-receptor associated leukoencephalopathy with hematopoietic stem cell transplant

Authors: Caroline G. Bergner, Lisa Schäfer, Vladan Vucinic, Birthe Schetschorke, Julia Lier, Cordula Scherlach, Michael Rullmann, Osama Sabri, Joseph Classen, Uwe Platzbecker, Jörn-Sven Kühl, Henryk Barthel, Wolfgang Köhler, Georg-Nikolaus Franke

Source: Frontiers in Neurology, Vol 14 (2023)

Subject Terms: ALSP, CSF1R-related leukoencephalopathy, white matter dementia, hematopoetic stem cell transplant, microglia, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2023.1163107/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/d1748348c342489cac6dc03a759cd654

Trem2 Enhances Demyelination in the Csf1r+/− Mouse Model of Leukoencephalopathy

Authors: Fabrizio Biundo, Violeta Chitu, Şölen Gökhan, Edward Chen, Jude Oppong-Asare, E. Richard Stanley

Source: Biomedicines, Vol 11, Iss 8, p 2094 (2023)

Subject Terms: HDLS, ALSP, CSF-1 receptor, TREM2, demyelination, corpus callosum, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/8/2094; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/2c79e0d77c4e4f68b78e1da745df10a2

Attenuated CSF‐1R signalling drives cerebrovascular pathology

Authors: Conor Delaney, Michael Farrell, Colin P Doherty, Kiva Brennan, Eoin O’Keeffe, Chris Greene, Kieva Byrne, Eoin Kelly, Niamh Birmingham, Paula Hickey, Simon Cronin, Savvas N Savvides, Sarah L Doyle, Matthew Campbell

Source: EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-17 (2020)

Subject Terms: adult‐onset leucoencephalopathy with axonal spheroids and pigmented glia (ALSP), blood, brain barrier, CSF‐1, CSF‐1R, IL‐34, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/9ed5f11fcad84fb6b9cf6cc689b7853f

Adult-onset diffuse leukoencephalopathy with axonal spheroids and pigmented glia presenting with acute stroke-like symptoms: A rare clinical scenario

Authors: Bela Purohit, MBBS, MD, DNB, FRCR (UK), EDiHNR, Faisal Johandi, MBBS, MRCS, Yih Yian Sitoh, MBBS, FRCR, FAMS, Adeline Ng, MBChB, MRCP (UK), Carol Tham, MBBS, MRCP (UK)

Source: Radiology Case Reports, Vol 15, Iss 10, Pp 1915-1920 (2020)

Subject Terms: Young stroke, ALSP, Cognitive dysfunction, T2 white matter hyperintensity, CSF1R gene, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1930043320303769; https://doaj.org/toc/1930-0433

Access URL: https://doaj.org/article/bb6efcc9e99b4b2a936c03db70f02466

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy

Authors: Liam Kempthorne, Hyejin Yoon, Charlotte Madore, Scott Smith, Zbigniew K. Wszolek, Rosa Rademakers, Jungsu Kim, Oleg Butovsky, Dennis W. Dickson

Source: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)

Subject Terms: CSF-1R-related leukoencephalopathy, Hereditary diffuse leukoencephalopathy with spheroids (HDLS), Adult leukoencephalopathy with spheroids and pigmented glia (ALSP), CSF-1R, CSF-1, Microglia, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-020-00947-0; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/b1b9c6cca2d44311a640d9d8c7a0223e

Hematopoietic Stem Cell Transplantation in CSF1R-Related Leukoencephalopathy: Retrospective Study on Predictors of Outcomes

Authors: Jarosław Dulski, Michael G. Heckman, Launia J. White, Kamila Żur-Wyrozumska, Troy C. Lund, Zbigniew K. Wszolek

Source: Pharmaceutics, Vol 14, Iss 12, p 2778 (2022)

Subject Terms: adult-onset, axonal spheroids, pigmented glia, ALSP, HSCT, bone marrow transplant, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/12/2778; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/b8c9368898d249918d7b012eeb8bb3ba

Pathologic basis of the preferential thinning of thecorpus callosum in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Authors: Michiaki Kinoshita, Kiyomitsu Oyanagi, Yasufumi Kondo, Keisuke Ishizawa, Kenji Ishihara, Mari Yoshida, Teruhiko Inoue, Yoshio Mitsuyama, Kunihiro Yoshida, Mitsunori Yamada, Yoshiki Sekijima, Shu-ichi Ikeda

Source: eNeurologicalSci, Vol 22, Iss , Pp 100310- (2021)

Subject Terms: ALSP, Corpus callosum, CSF1R, HDLS, Lesion staging, Microglia, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405650221000022; https://doaj.org/toc/2405-6502

Access URL: https://doaj.org/article/720d13c67e964e588877534c17779178

Loss of Ramified Microglia Precedes Axonal Spheroid Formation in Adult-Onset Leukoencephalopathy with Axonal Spheroids.

Authors: Murad Alturkustani, Qi Zhang, Basma AlYamany, Lee-Cyn Ang

Source: Free Neuropathology, Vol 1, Pp 27-27 (2020)

Subject Terms: adult-onset leukoencephalopathy with axonal spheroids, leukodystrophy, microglia, axonal spheroids, white matter, hdls, alsp, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2971; https://doaj.org/toc/2699-4445

Access URL: https://doaj.org/article/9bbe5e9d6acf43deb037029c86189567

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

Authors: Violeta Chitu, Solen Gokhan, Maria Gulinello, Craig A. Branch, Madhuvati Patil, Ranu Basu, Corrina Stoddart, Mark F. Mehler, E. Richard Stanley

Source: Neurobiology of Disease, Vol 74, Iss , Pp 219-228 (2015)

Subject Terms: Leukodystrophy, ALSP, HDLS, CSF-1R, Microglia, Dysmyelination, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996114003726; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/2c4d223a468d435ab24276222b636ce7

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Righting wrongs: the normality of constitutional politics
UK Association for Legal and Social Philosophy: Constitutionalism, democracy and sovereignty; American and European perspectives

Authors: Hart, V.

Source: AVEBURY SERIES IN PHILOSOPHY. :45-60

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN015431386&indx=1&recIds=ETOCCN015431386

Beyond sovereignty and citizenship: a global constitutionalism
UK Association for Legal and Social Philosophy: Constitutionalism, democracy and sovereignty; American and European perspectives

Authors: Ferrajoli, L.

Source: AVEBURY SERIES IN PHILOSOPHY. :151-159

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN015431440&indx=1&recIds=ETOCCN015431440

The political meaning of constitutionalism
UK Association for Legal and Social Philosophy: Constitutionalism, democracy and sovereignty; American and European perspectives

Authors: Preuss, U. K.

Source: AVEBURY SERIES IN PHILOSOPHY. :11-30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN015431365&indx=1&recIds=ETOCCN015431365

The European Union?
UK Association for Legal and Social Philosophy: Constitutionalism, democracy and sovereignty; American and European perspectives

Authors: Bankowski, Z., Scott, A.

Source: AVEBURY SERIES IN PHILOSOPHY. :77-95

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN015431409&indx=1&recIds=ETOCCN015431409