Qing Hua Chang Yin ameliorates chronic colitis in mice by inhibiting PERK–ATF4–CHOP pathway of ER stress and the NF-κB signalling pathway

Authors: Liya Liu, Youqin Chen, Yuying Han, Xinran Zhang, Yulun Wu, Jing Lin, Liujing Cao, Meizhu Wu, Huifang Zheng, Yi Fang, Lihui Wei, Thomas J. Sferra, Anjum Jafri, Xiao Ke, Jun Peng, Aling Shen

Source: Pharmaceutical Biology, Vol 62, Iss 1, Pp 607-620 (2024)

Subject Terms: Ulcerative colitis, high-throughput RNA sequencing, endoplasmic reticulum stress, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116

Access URL: https://doaj.org/article/942f776fc7894a3895d95242b37c2669

Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways

Authors: Liya Liu, Ying Cheng, Guosheng Lin, Huifang Zheng, Xinran Zhang, Peilin Zhao, Meixuan Guo, Qihong Liu, Wenyi Fang, Wenrong Wang, Anjum Jafri, Aling Shen, Xiao Ke, Youqin Chen

Source: Frontiers in Pharmacology, Vol 16 (2025)

Subject Terms: Jianpi Qinghua Sanyu Yin, raised erosive gastritis, ceRNA, miR-122-5p, PI3K/Akt signaling pathways, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1495020/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/1be4ba321cc04e4c961db6f9e692a780

miR-326 overexpression inhibits colorectal cancer cell growth and proteasome activity by targeting PNO1: unveiling a novel therapeutic intervention strategy

Authors: Yi Fang, Yulun Wu, Xinran Zhang, Lihui Wei, Liya Liu, Youqin Chen, Daxin Chen, Nanhui Xu, Liujin Cao, Jie Zhu, Mian Chen, Ying Cheng, Thomas J. Sferra, Mengying Yao, Aling Shen, Jun Peng

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Subject Terms: Colorectal cancer, PNO1, MiR-326, Proteasome assembly, P27KIP1, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d95710292bd646cf8f0a348cc899a937

Therapeutic potential of Pien Tze Huang in colitis-associated colorectal cancer: mechanistic insights from a mouse model

Authors: Liya Liu, Youqin Chen, Sijia Liu, Xinran Zhang, Liujing Cao, Yulun Wu, Yuying Han, Guosheng Lin, Lihui Wei, Yi Fang, Thomas J. Sferra, Anjum Jafri, Huixin Liu, Li Li, Aling Shen

Source: Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)

Subject Terms: Pien Tze Huang, Azoxymethane (AOM)/dextran sodium sulfate (DSS), Colitis-associated colorectal cancer, Wnt/β-catenin signaling pathway, RNA-seq, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/33150c0839b143969b029647a00fe863

Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC2 pathway activation

Authors: Zhi Guo, Xuan Yang, Meizhu Wu, Aling Shen, Jiapeng Li, Xiuli Zhang, Ying Cheng, Qiurong Xie, Jun Peng

Source: Pharmaceutical Biology, Vol 61, Iss 1, Pp 858-867 (2023)

Subject Terms: Hypertension, vascular smooth muscle cells, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116

Access URL: https://doaj.org/article/d2a3c571ab7e475ba6aa6c750aadb8cb

Gastrodin Alleviates Angiotensin II-Induced Hypertension and Myocardial Apoptosis via Inhibition of the PRDX2/p53 Pathway In Vivo and In Vitro

Authors: Nanhui Xu, Qiurong Xie, Youqin Chen, Jiapeng Li, Xiuli Zhang, Huifang Zheng, Ying Cheng, Meizhu Wu, Aling Shen, Lihui Wei, Mengying Yao, Yanyan Yang, Thomas J. Sferra, Anjum Jafri, Yi Fang, Jun Peng

Source: Pharmaceuticals, Vol 17, Iss 9, p 1200 (2024)

Subject Terms: gastrodin, hypertension, cardiac protection, myocardial apoptosis, angiotensin II, PRDX2/p53 pathway, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/9/1200; https://doaj.org/toc/1424-8247

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Effects of Liqi Tongbian decoction on gut microbiota, SCFAs production, and 5-HT pathway in STC rats with Qi Stagnation Pattern

Authors: Qihong Liu, Danfeng Ke, Youqin Chen, Aling Shen, Liya Liu, Lunan Hu, Yan Ren, Wenyi Fang, Peilin Zhao, Thomas J. Sferraf, Yunfeng Luo, Xiao Ke

Source: Frontiers in Microbiology, Vol 15 (2024)

Subject Terms: slow transit constipation, Liqi Tongbian decoction, gut microbiota, short-chain fatty acids, serotonin, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1337078/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/1a7653a4247443cc9e766c157945ca10

Based on network pharmacology, gastrodin attenuates hypertension-induced vascular smooth muscle cell proliferation and PI3K/AKT pathway activation

Authors: Aling Shen, Meizhu Wu, Farman Ali, Zhi Guo, Yi Fang, Yuting Zhou, Siyu Zhang, Wenqiang Zhang, Ying Wen, Min Yu, Jun Peng, Keji Chen

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6e734266f8a6410589aa43e8f8341890

Qing Hua Chang Yin alleviates chronic colitis of mice by protecting intestinal barrier function and improving colonic microflora

Authors: Yuying Han, Liya Liu, Youqin Chen, Huifang Zheng, Mengying Yao, Liujing Cao, Thomas J. Sferra, Xiao Ke, Jun Peng, Aling Shen

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: Qing Hua Chang Yin, chronic colitis, pro-inflammatory cytokines, tight junction protein, intestinal microflora, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1176579/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/de620078f22e4fcaadd8fbba993eaef9

Refined Baohe formula protects against 5-fluorouracil-induced intestinal mucositis by modulating AKT pathway in CT-26 tumor-bearing mice

Authors: Liya Liu, Youqin Chen, Ying Cheng, Meizhu Wu, Jie Li, Jiapeng Li, Thomas Joseph Sferra, Senthilkumar Sankararaman, Jianfeng Chu, Aling Shen, Jun Peng

Source: Pharmacological Research - Modern Chinese Medicine, Vol 7, Iss , Pp 100230- (2023)

Subject Terms: Refined baohe formula, Colorectal cancer, 5-fluorouracil, Intestinal mucositis, AKT pathway, Other systems of medicine, RZ201-999, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667142523000167; https://doaj.org/toc/2667-1425

Access URL: https://doaj.org/article/22b15ddd515a4e1f90679cbbbb0a43bb

Qingda granules mitigate cardiac inflammation in spontaneously hypertensive rats via the MCP-1/CCR2 signaling pathway

Authors: Jianfeng CHU, Huai WANG, Tianyi WANG, Meizhong PENG, Xueling ZHOU, Yan LU, Shan LIN, Aling SHEN, Changgeng FU, Jun PENG

Source: Journal of Holistic Integrative Pharmacy, Vol 2, Iss 4, Pp 249-260 (2021)

Subject Terms: Qingda granules, Hypertension, Cardiac inflammation, MCP-1/CCR2 pathway, Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2707368823000699; https://doaj.org/toc/2707-3688

Access URL: https://doaj.org/article/1799c72004cb430aa3a056d964c4515a

Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis

Authors: Ying Wen, Xiuli Zhang, Lihui Wei, Meizhu Wu, Ying Cheng, Huifang Zheng, Aling Shen, Changgeng Fu, Farman Ali, Linzi Long, Yao Lu, Jiapeng Li, Jun Peng

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: gastrodin, hypertension, renal fibrosis, TGF-β1/Smad2/3, network pharmacology, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1082281/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/cf09450bd05b4b7b99897907f48605ea

Upregulation of SNTB1 correlates with poor prognosis and promotes cell growth by negative regulating PKN2 in colorectal cancer

Authors: Liya Liu, Youqin Chen, Xiaoying Lin, Meizhu Wu, Jiapeng Li, Qiurong Xie, Thomas J. Sferra, Yuying Han, Huixin Liu, Liujing Cao, Mengying Yao, Jun Peng, Aling Shen

Source: Cancer Cell International, Vol 21, Iss 1, Pp 1-14 (2021)

Subject Terms: Colorectal cancer, Syntrophin beta 1, Growth, Overall survival, Protein kinase N2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/404c378368a94af6bf3788c451291208

Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach

Authors: Di Wang, Farman Ali, Huixin Liu, Ying Cheng, Meizhu Wu, Muhammad Zubair Saleem, Huifang Zheng, Lihui Wei, Jiangfeng Chu, Qiurong Xie, Aling Shen, Jun Peng

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: networking pharmacology, JAK2, quercetin, vascular smooth muscle cells, stat3, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1002363/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/e7060872a2054be5b19a429ffcb8415a

Corrigendum: Swimming attenuates muscle wasting and mediates multiple signaling pathways and metabolites in CT-26 bearing mice

Authors: Jiapeng Li, Qiurong Xie, Liya Liu, Ying Cheng, Yuying Han, Xiaoping Chen, Jia Lin, Zuanfang Li, Huixin Liu, Xiuli Zhang, Haichun Chen, Jun Peng, Aling Shen

Source: Frontiers in Molecular Biosciences, Vol 9 (2022)

Subject Terms: swimming, colorectal cancer, muscle wasting, NF-κB, metabolite, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.1005797/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/244ca03fdd394ee0a586a1adf632fa4c

Qingda Granule Attenuates Angiotensin II-Induced Renal Apoptosis and Activation of the p53 Pathway

Authors: Linzi Long, Xiuli Zhang, Ying Wen, Jiapeng Li, Lihui Wei, Ying Cheng, Huixin Liu, Jianfeng Chu, Yi Fang, Qiurong Xie, Aling Shen, Jun Peng

Source: Frontiers in Pharmacology, Vol 12 (2022)

Subject Terms: Qingda granule, hypertension, renal injury, Ang II, p53 pathway, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.770863/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/c97d1d6393754ea2a70c9330d0bfeec1

Down-Regulating HAUS6 Suppresses Cell Proliferation by Activating the p53/p21 Pathway in Colorectal Cancer

Authors: Aling Shen, Liya Liu, Yue Huang, Zhiqing Shen, Meizhu Wu, Xiaoping Chen, Xiangyan Wu, Xiaoying Lin, Youqin Chen, Li Li, Ying Cheng, Jianfeng Chu, Thomas J. Sferra, Lihui Wei, Qunchuan Zhuang, Jun Peng

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2022)

Subject Terms: HAUS6, tumor growth, proliferation, p53/p21 pathway, survival, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.772077/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/5782521791a840828b5ec4160ae9fe3b

Isolated Diastolic Hypertension and Risk of Cardiovascular Events: A Systematic Review and Meta-Analysis of Cohort Studies With 489,814 Participants

Authors: Mingyan Huang, Linzi Long, Ling Tan, Aling Shen, Mi Deng, Yuxuan Peng, Wenwen Yang, Hongzheng Li, Yue Wei, Meng Li, Feifei Liao, Chao Liu, Aimei Lu, Hua Qu, Changgeng Fu, Keji Chen

Source: Frontiers in Cardiovascular Medicine, Vol 8 (2022)

Subject Terms: isolated diastolic hypertension, cardiovascular events, cardiovascular mortality, stroke, meta-analysis, cohort study, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.810105/full; https://doaj.org/toc/2297-055X

Access URL: https://doaj.org/article/d6e44aec37164241ad89ad356820432d

Swimming Attenuates Muscle Wasting and Mediates Multiple Signaling Pathways and Metabolites in CT-26 Bearing Mice

Authors: Jiapeng Li, Qiurong Xie, Liya Liu, Ying Cheng, Yuying Han, Xiaoping Chen, Jia Lin, Zuanfang Li, Huixin Liu, Xiuli Zhang, Haichun Chen, Jun Peng, Aling Shen

Source: Frontiers in Molecular Biosciences, Vol 8 (2022)

Subject Terms: swimming, colorectal cancer, muscle wasting, NF-κB, metabolite, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2021.812681/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/c11f326c4e7849258524b497e8121499

CCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro.

Authors: Weiquan Zeng, Meizhu Wu, Ying Cheng, Liya Liu, Yuying Han, Qiurong Xie, Jiapeng Li, Lihui Wei, Yi Fang, Youqin Chen, Jun Peng, Aling Shen

Source: PLoS ONE, Vol 17, Iss 12, p e0279851 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/3407f880e6e64dde891394ec3e89b42e