Computational high-throughput screening and in vitro approaches identify CB-006-3; A novel PI3K-BRAF^V600E dual targeted inhibitor against melanoma.

Authors: TOBEIGEI, FAISAL HASSAN, GAHTANI, REEM M., SHAIKH, AHMAD, ALI, AMER A. L., KAMELI, NADER, KAMLI, HOSSAM, RAJAGOPALAN, PRASANNA

Source: Oncology Research; 2021, Vol. 29 Issue 5, p305-318, 14p

Subject Terms: HIGH throughput screening (Drug development), MOLECULAR dynamics, PHOSPHATIDYLINOSITOL 3-kinases, SMALL molecules, NUCLEAR fragmentation, PHOSPHOINOSITIDES, MICROPHTHALMIA-associated transcription factor