Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis

Authors: Yu Zhang, Rong Wu, Xi Zhan, Xuan-Yi Wang, Lin-Wei Xiang, Ya-Qian Duan, Yan You, Jian-Bo Zhang, Rui Wu, Yun-Yuan Zhang, Liang Duan

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)

Subject Terms: AIM2 inflammasome, Pyroptosis, Neutrophil extracellular traps, Chronic liver inflammation/fibrosis, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/f12fa08df755413ca610fcac00224466

Shengmai-Yin resists myocardial ischemia reperfusion injury by inhibiting K27 ubiquitination of absent in melanoma 2

Authors: Xu, Xiaojin ^{a, b, 1}, Wang, Yuanyi ^{c, 1}, Pei, Ke ^{c, 1}, Mao, Chenhan ^{a, d}, Fang, Fei ^c, Zhou, Tiantong ^e, Zhang, Meng ^b, Meng, Pei-Na ^f, Wei, Zilun ^g, Liu, Chang ^c, Dai, Yang ^a, Yin, Rui ^a, Chen, Zhaoyang ^a, Wang, Xindong ^{a, d, ⁎}

Source: In Journal of Ethnopharmacology 9 April 2025 345

Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease

Authors: Xu, Shuai ^a, Kong, Lina ^a, Li, Lin ^a, Wang, Changyuan ^a, Gu, Jiangning ^b, Luo, Haifeng ^b, Meng, Qiang ^{a, ⁎}

Source: In BBA - Molecular Basis of Disease February 2024 1870(2)

Taking AIM at Influenza: The Role of the AIM2 Inflammasome

Authors: Dianne W. Xu, Michelle D. Tate

Source: Viruses, Vol 16, Iss 10, p 1535 (2024)

Subject Terms: AIM2 inflammasome, influenza A virus, DNA sensing, cytosolic DNA, inflammation, immunotherapy, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/10/1535; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/300a7a7160fd4ae4ba752f8f0a759fec

Low‐Dose Chemotherapy Preferentially Shapes the Ileal Microbiome and Augments the Response to Immune Checkpoint Blockade by Activating AIM2 Inflammasome in Ileal Epithelial Cells

Authors: Congying Pu, Yize Li, Yixian Fu, Yiyang Yan, Siyao Tao, Shuai Tang, Xiameng Gai, Ziyi Ding, Zhenjie Gan, Yingluo Liu, Siyuwei Cao, Ting Wang, Jian Ding, Jun Xu, Meiyu Geng, Min Huang

Source: Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)

Subject Terms: AIM2 inflammasome, chemotherapy, gut microbiome, ileal epithelial cells, immune checkpoint blockade, lactobacillus, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/3b216d8657ec4b5ebcaf0e915308894b

New insights into nucleic acid sensor AIM2: The potential benefit in targeted therapy for cancer

Authors: Jian-Zhou Cui, Zhi Huan Chew, Lina H.K. Lim

Source: Pharmacological Research, Vol 200, Iss , Pp 107079- (2024)

Subject Terms: AIM2 Inflammasome, Cytosolic DNA, Pyroptosis, Immunotherapy, DNA-RNA Hybrids, PD-L1, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824000239; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/74ef71f974584448b53ae9e736cbb75e

High cell-free DNA is associated with disease progression, inflammasome activation and elevated levels of inflammasome-related cytokine IL-18 in patients with myelofibrosis

Authors: Geraldine De Luca, Paola R. Lev, Maria F. Camacho, Nora P. Goette, Federico Sackmann, Miguel A. Castro Ríos, Beatriz Moiraghi, Veronica Cortes Guerrieri, Georgina Bendek, Emiliano Carricondo, Alicia Enrico, Veronica Vallejo, Ana Varela, Marina Khoury, Marina Gutierrez, Irene B. Larripa, Rosana F. Marta, Ana C. Glembotsky, Paula G. Heller

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: myelofibrosis, inflammation, NLRP3 inflammasome, cell-free DNA, IL-18, AIM2 inflammasome, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161832/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5d6f229ff02c42ab976c494419308bc5

AIM2-inflammasome role in systemic lupus erythematous and rheumatoid arthritis

Authors: E. E. Uresti-Rivera, M. H. García-Hernández

Source: Autoimmunity, Vol 55, Iss 7, Pp 443-454 (2022)

Subject Terms: aim2 inflammasome, rheumatoid arthritis, systemic lupus erythematous, nephritis, joint inflammation, Internal medicine, RC31-1245

File Description: electronic resource

Relation: https://doaj.org/toc/0891-6934; https://doaj.org/toc/1607-842X

Access URL: https://doaj.org/article/80da8b58409547969290f20147464864

The BK Channel Limits the Pro-Inflammatory Activity of Macrophages

Authors: Yihe Chen, Nikita Markov, Lea Gigon, Aref Hosseini, Shida Yousefi, Darko Stojkov, Hans-Uwe Simon

Source: Cells, Vol 13, Iss 4, p 322 (2024)

Subject Terms: AIM2 inflammasome, BK channel, calcium influx, macrophage polarization, pro-inflammatory cytokine, kinase, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/4/322; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/8ba83f82ee23434fbf39fae61945088b

Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy

Authors: Bangzuo Ning, Jingjing Shen, Fanglin Liu, Hemin Zhang, Xin Jiang

Source: Microbiology Spectrum, Vol 11, Iss 3 (2023)

Subject Terms: Mycobacterium tuberculosis, baicalein, pyroptosis, autophagy, AIM2 inflammasome, NLRP3 inflammasome, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/54a62de9885d4920b7555f0f8b6fcb9f

Macrophage IL-1β contributes to tumorigenesis through paracrine AIM2 inflammasome activation in the tumor microenvironment

Authors: Zhi Huan Chew, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Tan, Shreya Kar, Kai Kiat Koh, Kritika Singh, Hong Meng Lim, Soo Chin Lee, Alan Prem Kumar, Stephan Gasser, Lina H. K. Lim

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: innate immunity, inflammasome, cytosolic DNA, tumor microenvironment, AIM2 inflammasome, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1211730/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0e7c66659b314a1588999179baf5069b

Cellular Senescence in Health, Disease and Aging: Blessing or Curse?

Contributors: Riessland, Markus

Subject Terms: γH2AX, Alzheimer’s disease, DNA damage, mild cognitive impairment, senescence, secreted protein acidic and rich in cysteine, regeneration, homeostasis, cellular senescence, biology of aging, neurodegeneration, brain, geroscience, senolytics, tauopathy, cancer, stress response, post-mitotic, neuronal senescence, amyotrophic lateral sclerosis, senescence-associated secretory phenotype (SASP), cell-cycle, melanoma, pancreatic adenocarcinoma, tumor infiltration, chemotherapy resistance, prostate, inflammation, AIM2 inflammasome, POP3, Research and information: general, Biology, life sciences

File Description: image/jpeg

Access URL: https://directory.doabooks.org/handle/20.500.12854/76942
https://mdpi.com/books/pdfview/book/4533

The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest

Authors: Rongjiao Shao, Xintao Wang, Tianhua Xu, Yiyang Xia, Derong Cui

Source: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-20 (2021)

Subject Terms: CHMP2A, AIM2 inflammasome, Autophagy, Inflammation, Cardiac arrest, Brain damage, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/26fbcb5679884ce9be37a13def6f99a4

AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke

Authors: Hai B. Tran, Rhys Hamon, Hubertus Jersmann, Miranda P. Ween, Patrick Asare, Rainer Haberberger, Harshita Pant, Sandra J. Hodge

Source: Journal of Inflammation, Vol 18, Iss 1, Pp 1-13 (2021)

Subject Terms: AIM2 inflammasome, AIM2 protein nuclear localization, COPD, Cigarette smoke, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1476-9255

Access URL: https://doaj.org/article/06034dcccc57403981b2900086cdefd2

Roles of AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis

Authors: Jieyi Wang, Jing Gao, Cong Huang, Sohyun Jeong, Randy Ko, Xue Shen, Chaofeng Chen, Weilong Zhong, Yanfen Zou, Bo Yu, Changbing Shen

Source: Frontiers in Genetics, Vol 13 (2022)

Subject Terms: psoriasis, AIM2, AIM2 inflammasome, pathogenesis, treatment, Genetics, QH426-470

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fgene.2022.929162/full; https://doaj.org/toc/1664-8021

Access URL: https://doaj.org/article/6fde629427894d85acc79f77bcf4917a

AIM2 as a putative target in acute kidney graft rejection

Authors: Nathália Franchon Marques Tejada, João Vitor Ziroldo Lopes, Luis Eduardo Duarte Gonçalves, Izabela Mamede Costa Andrade da Conceição, Glória Regina Franco, Bruno Ghirotto, Niels Olsen Saraiva Câmara

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: kidney transplant, acute rejection (AR), AIM2 inflammasome, biomarker, bioinformatics, inflammasome, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.839359/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/86d3d511deac4a408b665d39ab3cf1c3

Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation

Authors: Huijeong Ahn, Byung-Cheol Han, Seung-Ho Lee, Geun-Shik Lee

Source: Journal of Ginseng Research, Vol 44, Iss 6, Pp 808-814 (2020)

Subject Terms: Korean Red Ginseng extract, Non-saponin, Fructose-arginine, AIM2 inflammasome, Botany, QK1-989

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1226845320301093; https://doaj.org/toc/1226-8453

Access URL: https://doaj.org/article/2a9efa07b6704967979ea404ae28806f

Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation

Authors: Ying Wang, Chaojie Chen, Jiajun Chen, Tingting Sang, He Peng, Xiaojian Lin, Qian Zhao, Shengjia Chen, Thomas Eling, Xingya Wang

Source: Redox Biology, Vol 52, Iss , Pp 102322- (2022)

Subject Terms: NAG-1/GDF15, Hepatic steatosis, Lipid metabolism, AIM2 inflammasome, ROS, dsDNA, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231722000945; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/2c697e3be5724b16b41af04512a1e9ba

Activation of the AIM2 Receptor in Circulating Cells of Post-COVID-19 Patients With Signs of Lung Fibrosis Is Associated With the Release of IL-1α, IFN-α and TGF-β

Authors: Chiara Colarusso, Michela Terlizzi, Angelantonio Maglio, Antonio Molino, Claudio Candia, Carolina Vitale, Philip M. Hansbro, Alessandro Vatrella, Aldo Pinto, Rosalinda Sorrentino

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: SARS–CoV–2, AIM2 inflammasome, post-COVID-19, cytokines, post-COVID-19 lung fibrosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.934264/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/146083c0b6a04f19926bce4c3b522575

Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

Authors: Yonghe Zheng, Wenwen Tang, Hanhai Zeng, Yucong Peng, Xiaobo Yu, Feng Yan, Shenglong Cao

Source: Frontiers in Neurology, Vol 13 (2022)

Subject Terms: AIM2 inflammasome, early brain injury, neurons, pannexin-1, subarachnoid hemorrhage, probenecid, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2022.854671/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/4f432496440f436f86f78d5cd157c5ed