PARPs and ADP-ribosylation-mediated biomolecular condensates: determinants, dynamics, and disease implications.

Authors: Liu, Hongrui^1,2 (AUTHOR), Pillai, Meenakshi¹ (AUTHOR), Leung, Anthony K.L.^1,3,4,5 (AUTHOR) anthony.leung@jhu.edu

Source: Trends in Biochemical Sciences. Mar2025, Vol. 50 Issue 3, p224-241. 18p.

Subject Terms: *PHASE separation, *ADP-ribosyltransferases, *ADP-ribosylation, *NUCLEIC acids, *BINDING sites

Using TLC-MALDI-TOF to Interrogate In Vitro Peptidyl Proximal Preferences of PARP14 and Glycohydrolase Specificity.

Authors: Javed, Zeeshan¹ (AUTHOR) cmohr@scu.edu, Nguyen, Hannah H.¹ (AUTHOR), Harker, Kiana K.¹ (AUTHOR), Mohr, Christian M.¹ (AUTHOR), Vano, Pia¹ (AUTHOR), Wallace, Sean R.¹ (AUTHOR), Silvers, Clarissa¹ (AUTHOR), Sim, Colin¹ (AUTHOR), Turumella, Soumya¹ (AUTHOR), Flinn, Ally¹ (AUTHOR), Moritz, Anthony¹ (AUTHOR), Carter-O'Connell, Ian¹ (AUTHOR) icarteroconnell@scu.edu

Source: Molecules. Aug2023, Vol. 28 Issue 16, p6061. 15p.

Subject Terms: *AMINO acid sequence, *ADP-ribosyltransferases, *POLYMERASES, *NAD (Coenzyme), *FACTOR analysis, *TOXINS, *NICOTINAMIDE

ADP‐ribosyltransferases, an update on function and nomenclature.

Authors: Lüscher, Bernhard¹ (AUTHOR) luescher@rwth-aachen.de, Ahel, Ivan² (AUTHOR), Altmeyer, Matthias³ (AUTHOR), Ashworth, Alan⁴ (AUTHOR), Bai, Peter⁵ (AUTHOR), Chang, Paul⁶ (AUTHOR), Cohen, Michael⁷ (AUTHOR), Corda, Daniela⁸ (AUTHOR), Dantzer, Françoise⁹ (AUTHOR), Daugherty, Matthew D.¹⁰ (AUTHOR), Dawson, Ted M.¹¹ (AUTHOR), Dawson, Valina L.¹¹ (AUTHOR), Deindl, Sebastian¹² (AUTHOR), Fehr, Anthony R.¹³ (AUTHOR), Feijs, Karla L. H.¹ (AUTHOR), Filippov, Dmitri V.¹⁴ (AUTHOR), Gagné, Jean‐Philippe¹⁵ (AUTHOR), Grimaldi, Giovanna¹⁶ (AUTHOR), Guettler, Sebastian¹⁷ (AUTHOR), Hoch, Nicolas C.¹⁸ (AUTHOR)

Source: FEBS Journal. Dec2022, Vol. 289 Issue 23, p7399-7410. 12p.

Subject Terms: *ADP-ribosyltransferases, *PROTEIN synthesis, *GENETIC transcription regulation, *POST-translational modification, *DNA damage, *ADP-ribosylation, *POLY ADP ribose, *ZOOLOGICAL nomenclature, *NUCLEIC acids

Mitochondrial sirtuin 3 and role of natural compounds: the effect of post-translational modifications on cellular metabolism.

Authors: Oppedisano, Francesca¹ (AUTHOR), Nesci, Salvatore² (AUTHOR) salvatore.nesci@unibo.it, Spagnoletta, Anna³ (AUTHOR)

Source: Critical Reviews in Biochemistry & Molecular Biology. Jun/Aug2024, Vol. 59 Issue 3/4, p199-220. 22p.

Subject Terms: *POST-translational modification, *ADP-ribosyltransferases, *METABOLIC disorders, *CARBONYLATION, *MITOCHONDRIAL pathology, *SIRTUINS, *PHYTOCHEMICALS, *NAD (Coenzyme)

Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10.

Authors: Korn, Patricia¹ (AUTHOR), Classen, Arno² (AUTHOR), Murthy, Sudarshan³ (AUTHOR), Guareschi, Riccardo⁴ (AUTHOR), Maksimainen, Mirko M.³ (AUTHOR), Lippok, Barbara E.¹ (AUTHOR), Galera‐Prat, Albert³ (AUTHOR), Sowa, Sven T.³ (AUTHOR), Voigt, Catharina¹ (AUTHOR), Rossetti, Giulia^4,5,6 (AUTHOR), Lehtiö, Lari³ (AUTHOR), Bolm, Carsten² (AUTHOR), Lüscher, Bernhard¹ (AUTHOR) luescher@rwth-aachen.de

Source: ChemistryOpen. Oct2021, Vol. 10 Issue 10, p939-948. 10p.

Subject Terms: *ADP-ribosyltransferases, *DNA repair, *FUNCTIONAL groups, *POLY(ADP-ribose) polymerase, *ENZYMES

A ribose-functionalized NAD⁺ with versatile activity for ADP-ribosylation.

Authors: Stephens, Elisa N.¹ (AUTHOR), Zhang, Xiao-Nan¹ (AUTHOR), Lam, Albert T.¹ (AUTHOR), Li, Jiawei¹ (AUTHOR), Pei, Hua² (AUTHOR), Louie, Stan G.^2,3 (AUTHOR), Wang, Clay C. C.^1,4 (AUTHOR), Zhang, Yong^1,3,4,5 (AUTHOR) yongz@usc.edu

Source: Chemical Communications. 12/4/2023, Vol. 59 Issue 93, p13843-13846. 4p.

Subject Terms: *ADP-ribosylation, *ADP-ribosyltransferases, *POLYMERASES, *MOLECULES, *PROTEINS, *POLY ADP ribose

Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy.

Authors: Thumser-Henner, Pauline¹ (AUTHOR) pthumser@vetclinics.uzh.ch, Nytko, Katarzyna J.¹ (AUTHOR), Rohrer Bley, Carla¹ (AUTHOR)

Source: BMC Veterinary Research. 1/31/2020, Vol. 16 Issue 1, p1-9. 9p.

Subject Terms: *BRCA genes, *ADP-ribosyltransferases, *SINGLE nucleotide polymorphisms, *DOG diseases, *MOLECULAR genetics, *TUMORS

Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma.

Authors: Schallenberg, Simon¹ (AUTHOR) simon.schallenberg@uk-koeln.de, Bork, Julian¹ (AUTHOR), Essakly, Ahlem¹ (AUTHOR), Alakus, Hakan² (AUTHOR), Buettner, Reinhard¹ (AUTHOR), Hillmer, Axel M.¹ (AUTHOR), Bruns, Christiane² (AUTHOR), Schroeder, Wolfgang² (AUTHOR), Zander, Thomas³ (AUTHOR), Loeser, Heike¹ (AUTHOR), Gebauer, Florian² (AUTHOR), Quaas, Alexander¹ (AUTHOR)

Source: BMC Cancer. 1/6/2020, Vol. 20 Issue 1, p1-12. 12p. 5 Diagrams, 4 Charts, 1 Graph.

Subject Terms: *GENE amplification, *ADP-ribosyltransferases, *TUMORS, *ADENOSINE triphosphatase, *ESOPHAGUS

Role of Olaparib as Maintenance Treatment for Ovarian Cancer: The Evidence to Date.

Authors: Montemorano, Lauren (AUTHOR), Lightfoot, Michelle DS (AUTHOR), Bixel, Kristin (AUTHOR)

Source: OncoTargets & Therapy. Dec2019, Vol. 12, p11497-11506. 10p.

Subject Terms: *OVARIAN cancer, *ADP-ribosyltransferases, *CANCER treatment, *ONCOLOGY, *EVIDENCE

2,4-Dihydroxy-3′-methoxy-4′-ethoxychalcone suppresses cell proliferation and induces apoptosis of multiple myeloma via the PI3K/akt/mTOR signaling pathway.

Authors: Zhu, FengChen¹ (AUTHOR), Jiang, DianMing² (AUTHOR) jdm5710266@163.com, Zhang, MingHua¹ (AUTHOR), Zhao, Bo¹ (AUTHOR)

Source: Pharmaceutical Biology. Dec2019, Vol. 57 Issue 1, p641-648. 8p.

Subject Terms: *MULTIPLE myeloma, *ADP-ribosyltransferases, *CELL proliferation, *RAPAMYCIN, *WESTERN immunoblotting, *CD38 antigen, *TRADITIONAL medicine

Combined effects of XAF1 and TRAIL on the apoptosis of lung adenocarcinoma cells.

Authors: Zhang, Fuquan¹ (AUTHOR), Chen, Donglai² (AUTHOR), Yang, Wentao¹ (AUTHOR), Duan, Shanzhou¹ (AUTHOR), Chen, Yongbing¹ (AUTHOR) chentongt@sina.com

Source: Experimental & Therapeutic Medicine. Jun2019, Vol. 17 Issue 6, p4663-4669. 7p.

Subject Terms: *ADP-ribosyltransferases, *APOPTOSIS, *WESTERN immunoblotting, *POLYMERASE chain reaction, *LUNGS, *TRAIL protein

Evaluation of Drug–Drug Interactions of Rucaparib and CYP1A2, CYP2C9, CYP2C19, CYP3A, and P‐gp Substrates in Patients With an Advanced Solid Tumor.

Authors: Xiao, Jim J.¹, Watkins, Simon², Nowak, Dorota³, Ramlau, Rodryg³, Tomaszewska‐Kiecana, Monika³, Wysocki, Piotr J.³, Isaacson, Jeff³, Beltman, Jeri³, Nash, Eileen³, Kaczanowski, Robert³, Arold, Gerhard³

Source: CTS: Clinical & Translational Science. Jan2019, Vol. 12 Issue 1, p58-65. 8p.

Subject Terms: *TUMORS, *ADP-ribosyltransferases, *MIDAZOLAM, *WARFARIN, *CONFIDENCE intervals

Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells.

Authors: He, Jie^1,2, Li, Yongyun^1,2, Wang, Ying^1,2, Zhang, He^1,2, Ge, Shengfang^1,2 geshengfang@sjtu.edu.cn, Fan, Xianqun^1,2 geshengfang@sjtu.edu.cn

Source: Oncology Letters. May2018, Vol. 15 Issue 5, p7053-7059. 7p.

Subject Terms: *MELANOMA, *ADP-ribosyltransferases, *CANCER cell migration, *SMALL interfering RNA, *HAIRPIN (Genetics)

ADP-Ribosylation in Pathogens

Contributors: Leung, Anthony K L, Fehr, Anthony, Abraham, Rachy

Subject Terms: coronavirus, alphavirus, SARS-CoV-2, macrodomain, ADP-ribosylation, ADP-ribosylhydrolase, therapeutics, 14-3-3 activated bacterial exotoxins, actin, Aeromonas salmonicid, protein refolding, type III secretion system, Pseudomonas aeruginosa, toxin–antitoxin, DarT/DarG, DNA modification, cell growth, phage defence, antimicrobial resistance, PARylation, MARylation, post-translational modifications, viral infection, antiviral response, IFN-I, innate immunity, COVID-19, non-structural protein 3 (NSP3), drug discovery and development, virtual screening, hydrolase, interferon, PARP, RNA-virus, Legionella pneumophila, SidE family, effector, PR-ubiquitination, host-pathogen interaction, host–virus evolution, phylogenetics, alphaviruses, coronaviruses, PARG, Trypanosoma, Leishmania, poly ADP-ribosylation, Aedes aegypti, tankyrase, chikungunya virus (CHIKV), immunity, mass spectrometry, proteomics, poly(ADP-ribose) glycohydrolase, Diphtheria toxin-like ADP-ribosyltransferases, chronic infection, arboviruses, cardiovascular disease, emphysema, alcoholic liver disease, host–pathogen interactions, Mac1, inhibitors, PARP1, DNA virus, epigenetic, viral gene regulation, Mathematics and Science, Biology, life sciences, Microbiology (non-medical), Medical microbiology and virology

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/139225
https://mdpi.com/books/pdfview/book/9220

PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation.

Authors: Ribeiro, Victoria Chaves, Russo, Lilian Cristina, Hoch, Nícolas Carlos

Source: EMBO Journal; Jul2024, Vol. 43 Issue 14, p2908-2928, 21p

Subject Terms: ADP-ribosylation, INTERFERONS, UBIQUITIN ligases, ADP-ribosyltransferases, PROTEIN stability, VIRUS diseases

General ADP-Ribosylation Mechanism Based on the Structure of ADP-Ribosyltransferase–Substrate Complexes.

Authors: Tsuge, Hideaki, Habuka, Noriyuki, Yoshida, Toru

Source: Toxins; Jul2024, Vol. 16 Issue 7, p313, 14p

Subject Terms: ADP-ribosylation, CELL physiology, NUCLEIC acids, ADP-ribosyltransferases, AMINO acids

Dynamics of Scabin toxin. A proposal for the binding mode of the DNA substrate.

Authors: Lugo, Miguel R.¹, Lyons, Bronwyn^1,2, Lento, Cristina^3,4, Wilson, Derek J.^3,4, Merrill, A. Rod¹ rmerrill@uoguelph.ca

Source: PLoS ONE. 3/15/2018, Vol. 13 Issue 3, p1-30. 30p.

Subject Terms: *ADP-ribosyltransferases, *STREPTOMYCES scabies, *NAD (Coenzyme), *HYDROGEN-deuterium exchange, *CRYSTAL structure

Olaparib protects cardiomyocytes against oxidative stress and improves graft contractility during the early phase after heart transplantation in rats.

Authors: Korkmaz‐Icöz, Sevil¹, Szczesny, Bartosz², Marcatti, Michela², Li, Shiliang¹, Ruppert, Mihály¹, Lasitschka, Felix³, Loganathan, Sivakkanan¹, Szabó, Csaba², Szabó, Gábor¹ szabog69@googlemail.com, Korkmaz-Icöz, Sevil¹ (AUTHOR)

Source: British Journal of Pharmacology. Jan2018, Vol. 175 Issue 2, p246-261. 16p. 1 Color Photograph, 3 Charts, 7 Graphs.

Subject Terms: *ADP-ribosyltransferases, *CANCER treatment, *HEART cells, *OXIDATIVE stress, *LABORATORY rats, *TRANSPLANTATION of organs, tissues, etc.

Neuroprotective effects of a novel poly ( ADP-ribose) polymerase-1 inhibitor, JPI-289, in hypoxic rat cortical neurons.

Authors: Kim, Youngchul^1,2, Kim, Young S.², Noh, Min‐Young², Lee, Hanchang¹, Joe, Boyoung¹, Kim, Hyun Y.², Kim, Jeongmin¹, Kim, Seung H.² kimsh1@hanyang.ac.kr, Park, Jiseon¹ jiseonpark@jeilpharm.co.kr

Source: Clinical & Experimental Pharmacology & Physiology. Jun2017, Vol. 44 Issue 6, p671-679. 9p. 1 Diagram, 2 Charts, 4 Graphs.

Subject Terms: *POLYMERASES, *ADP-ribosyltransferases, *APOPTOSIS, *NECROSIS, *BRAIN injuries, *LABORATORY rats, *NEURAL stem cells, *LACTATE dehydrogenase

High-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair.

Authors: Dhakar, Saurabh S., Galera-Prat, Albert, Lehtiö, Lari

Source: Scientific Reports; 2/28/2024, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: HIGH throughput screening (Drug development), DNA damage, DNA repair, ADP-ribosyltransferases, DRUG development