Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential

Authors: Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-25 (2025)

Subject Terms: Chromene, Anti-obesity agent, Adipogenesis, Lipolysis, 3T3-L1, Adipocyte, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

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Oyster Mushroom (Pleurotus ostreatus) Ethanolic Extract Inhibits Pparg Expression While Maintaining the Methylation of the Pparg Promoter During 3T3-L1 Adipocyte Differentiation

Authors: Ariyanto EF, Farahana AK, Sudirman GSJ, Widiarsih E, Qomarilla N, Rahayu NS, Wikayani TP, Heryaman H, Wira DW, Triatin RD, Bashari MH, Pamela Y, Pratiwi YS, Ghozali M

Source: Journal of Experimental Pharmacology, Vol Volume 17, Pp 27-36 (2025)

Subject Terms: obesity, oyster mushroom, pparg expression, pparg methylation, 3t3-l1, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/oyster-mushroom-pleurotus-ostreatus-ethanolic-extract-inhibits-pparg-e-peer-reviewed-fulltext-article-JEP; https://doaj.org/toc/1179-1454

Access URL: https://doaj.org/article/a3dc1f8586c443149e96e527fa74179b

TGF‐β effects on adipogenesis of 3T3‐L1 cells differ in 2D and 3D cell culture conditions

Authors: Araya Umetsu, Megumi Watanabe, Tatsuya Sato, Megumi Higashide, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro

Source: FEBS Open Bio, Vol 14, Iss 12, Pp 2026-2037 (2024)

Subject Terms: 3D culture, 3T3‐L1 cell, adipogenesis, TGF‐β isoform, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/0f2d40a97cae4dd99e7153c937ad7484

Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug

Authors: Lorenzo Flori, Giulia Galgani, Giorgia Bray, Chiara Ippolito, Cristina Segnani, Carolina Pellegrini, Valentina Citi, Nunzia Bernardini, Alma Martelli, Vincenzo Calderone

Source: Frontiers in Pharmacology, Vol 16 (2025)

Subject Terms: browning, beige adipocyte, white adipocyte, adipocyte differentiation, 3T3-L1, PPAR-γ, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2025.1546456/full; https://doaj.org/toc/1663-9812

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Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K/AKT signaling pathway

Authors: Tianlan Li, Yiwa Liu, Jingyi Cao, Xianzhu Lu, Yinghan Lu, Yuhan Wang, Chunmei Zhang, Meifen Wu, Song Deng, Li Li, Ming Shi

Source: Environment International, Vol 198, Iss , Pp 109428- (2025)

Subject Terms: Triphenyl phosphate, 3T3-L1 preadipocytes, Lipid metabolism, Adipogenic differentiation, PI3K/AKT signaling pathway, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412025001795; https://doaj.org/toc/0160-4120

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Extraction and characterization of passion fruit seed oil and investigation of its hypolipidemic activity

Authors: Peihang Chen, Xiaoying Zhang, Qiubian Yang, Liang Li, Yong Cao, Ruimin Zhong, Jianyin Miao

Source: Journal of Agriculture and Food Research, Vol 19, Iss , Pp 101672- (2025)

Subject Terms: Low-temperature continuous phase transition extraction, Passion fruit seed oil, Fatty acid composition, Active ingredients, Hypolipidemic, 3T3-L1 preadipocytes, Agriculture (General), S1-972, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666154325000432; https://doaj.org/toc/2666-1543

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Cleavage and polyadenylation factors are potential regulators of adipogenesis

Authors: Salwa Mohd Mostafa, Claire Moore

Source: BMC Research Notes, Vol 17, Iss 1, Pp 1-6 (2024)

Subject Terms: Cleavage and polyadenylation, Adipogenesis, 3T3-L1, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/4fb8bde331524679a58593a117e44310

Effect of Luteoloside on 3T3-L1 Preadipocyte Differentiation and Lipid Metabolism

Authors: YANG Meng, REN Ziyi, MI Si, FENG Danqi, CHENG Xinying, FENG Xue, LIU Weihua, WANG Xianghong

Source: Shipin Kexue, Vol 45, Iss 18, Pp 116-123 (2024)

Subject Terms: luteoloside, 3t3-l1 preadipocytes, differentiation, lipid metabolism, obesity, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-18-013.pdf; https://doaj.org/toc/1002-6630

Access URL: https://doaj.org/article/42d4acc9f50d4b1eaa284cd47ab90029

Sulfated glycosaminoglycan CIP-3 from edible marine octopus Cistopus indicus: A promising bioactive with anti-hyperglycemic effects in 3T3-L1 adipocytes for functional food applications

Authors: Paulose, Silpa Kunnappilly ^{a, b}, Chakraborty, Kajal ^{a, ⁎}

Source: In Food Bioscience April 2025 66

The obesogenic effects of Bisphenol A and its analogues are differentially regulated via PPARγ transactivation in mouse 3T3-L1 cells

Authors: Crosthwait, Jennifer ^a, Syeddan, Syed ^a, Atlas, Ella ^{a, b, ⁎}

Source: In Toxicology in Vitro April 2025 104

The effects of citalopram and sertraline on adipogenesis and lipogenesis in 3T3-L1 cells

Authors: Bozdag, Deniz ¹, Entezari, Bita ¹, Gurer-Orhan, Hande ^⁎

Source: In Toxicology Letters March 2025 405:67-75

Thymoquinone inhibits adipocyte development in 3T3-L1 cells system by modulating the AKT and AMPK signaling pathways

Authors: Ahmed, Shamima ^{a, b}, Nishigaki, Yuki ^a, Ali, Mohammad Shaokat ^{a, b}, Matsui-Yuasa, Isao ^a, Kojima-Yuasa, Akiko ^{a, ⁎}

Source: In Pharmacological Research - Natural Products March 2025 6

Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1

Authors: Tao, Tao ^{a, 1}, Xu, Yanting ^{a, 1}, Zhang, Cheng-hui ^a, Zhang, Xian ^{a, b, ⁎}, Chen, Juan ^{a, b, ⁎}, Liu, Jian ^{a, b, ⁎}

Source: In BBA - Molecular and Cell Biology of Lipids March 2025 1870(2)

Engagement of peroxisome proliferator-activated receptor gamma (PPARγ) and mammalian target of rapamycin (mTOR) in the triclosan-induced disruption of Cyp450 enzyme activity in an in vitro model of mouse embryo fibroblasts (3T3-L1)

Authors: Szychowski, Konrad A. ^{a, ⁎, 1}, Skóra, Bartosz ^{a, 2}, Wójtowicz, Anna K. ^{b, 3}

Source: In Toxicology February 2025 511

Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation

Authors: Ankit P. Laddha, Aniket Wahane, Raman Bahal, José E. Manautou

Source: Frontiers in Molecular Biosciences, Vol 11 (2024)

Subject Terms: 3T3-L1 cells, ABCC transporter, adipogenesis, lipids, siRNA, cAMP, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2024.1498946/full; https://doaj.org/toc/2296-889X

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Defining the role of 2,2’,4,4’-tetrabromodiphenyl ether in 3T3-L1 cellular differentiation by transcriptome sequencing analysis

Authors: Zao-Ling Liu, Aerna Qiayimaerdan, Yong Fan, Shu-Rui Jiang, Zunire Tuerxuna, Meng-Lin Wang, Haiqiemuhan Abudureheman

Source: Adipocyte, Vol 13, Iss 1 (2024)

Subject Terms: 3T3-L1, BDE-47, adipogenesis, transcriptome sequencing, mitosis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Cytology, QH573-671, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3945; https://doaj.org/toc/2162-397X

Access URL: https://doaj.org/article/7a754217dcf94b6fbe30eb9893c2fded

Exploring the multiple effects of butein on adipogenic differentiation, inflammatory responses, and glucose metabolism in cellular models

Authors: Masanori Ohmoto, Atene Matsuya, Mika Mouri, Masaya Takemoto, Tohru Daikoku

Source: Food Chemistry Advances, Vol 5, Iss , Pp 100851- (2024)

Subject Terms: 3T3-L1 cells, RAW264 cells, Butein, Adipogenic differentiation, Reactive oxygen species, Inflammatory cytokine, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772753X24002466; https://doaj.org/toc/2772-753X

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Silybin restores glucose uptake after tumour necrosis factor-alpha and lipopolysaccharide stimulation in 3T3-L1 adipocytes

Authors: Alejandra Butanda-Nuñez, Octavio Rodríguez-Cortés, Espiridión Ramos-Martínez, Marco Antonio Cerbón, Galileo Escobedo, Anahí Chavarría

Source: Adipocyte, Vol 13, Iss 1 (2024)

Subject Terms: 3T3-L1 adipocytes, glucose uptake, inflammatory stimuli, LPS, silybin, TNFα, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Cytology, QH573-671, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3945; https://doaj.org/toc/2162-397X

Access URL: https://doaj.org/article/68ae987798d6409fb05f516973dde374

An improved in vitro 3T3-L1 adipocyte model of inflammation and insulin resistance

Authors: Ifeoluwa A. Odeniyi, Bulbul Ahmed, Benjamin Anbiah, Grace Hester, Peter T. Abraham, Elizabeth A. Lipke, Michael W. Greene

Source: Adipocyte, Vol 13, Iss 1 (2024)

Subject Terms: Adipocyte, inflammation, insulin resistance, in vitro model, 3T3-L1 cells, Diseases of the endocrine glands. Clinical endocrinology, RC648-665, Cytology, QH573-671, Physiology, QP1-981

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3945; https://doaj.org/toc/2162-397X

Access URL: https://doaj.org/article/fc2de475e9e44ab38af824874cbf36c1

Bacillus lipopeptides inhibit lipase activity and promote 3T3-L1 preadipocyte differentiation

Authors: Meichun Chen, Deju Chen, Rongfeng Xiao, Xuefang Zheng, Bo Liu, Jieping Wang

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

Subject Terms: Lipopeptide, lipase inhibitory activity, 3T3-L1 adipocyte differentiation, PPARγ, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/9dcc743c9ac349b7ba30bc5cfa1011a6