A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

Authors: Chrudinová, Martina, Kirk, Nicholas S., Chuard, Aurelien, Venugopal, Hari, Zhang, Fa, Lubos, Marta, Gelfanov, Vasily, Páníková, Terezie, Žáková, Lenka, Cutone, Julianne, Mojares, Matthew, DiMarchi, Richard, Jiráček, Jiří, Altindis, Emrah

Source: In Molecular Metabolism February 2024 80

Functional stapled fragments of human preptin of minimised lengthElectronic supplementary information (ESI) available. See DOI: 10.1039/d1ob02193a

Authors: Lubos, Marta, Mrázková, Lucie, Gwozdiaková, Petra, Pícha, Jan, Buděšínský, Miloš, Jiráček, Jiří, Kaminský, Jakub, Žáková, Lenka

Source: Organic & biomolecular chemistry. 20(12):2446-2454

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144716596.0x000001&indx=1&recIds=ETOCvdc_100144716596.0x000001

Characterization of viral insulins reveals white adipose tissue-specific effects in mice

Authors: Chrudinová, Martina, Moreau, François, Noh, Hye Lim, Páníková, Terezie, Žáková, Lenka, Friedline, Randall H., Valenzuela, Francisco A., Kim, Jason K., Jiráček, Jiří, Kahn, C. Ronald, Altindis, Emrah

Source: In Molecular Metabolism February 2021 44

Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications

Authors: Lubos, Marta, Pícha, Jan, Selicharová, Irena, Žák, Jíří, Buděšínský, Miloš, Mitrová, Katarína, Žáková, Lenka, Jiráček, Jiří

Source: Journal of peptide science. 29(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184689872.0x000001&indx=1&recIds=ETOCvdc_100184689872.0x000001

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

Alternate Title: Insulin and IGFs respond to equivalent mutations differently (English)

Authors: Macháčková, Kateřina, Mlčochová, Květoslava, Potalitsyn, Pavlo, Hanková, Kateřina, Socha, Ondřej, Buděšínský, Miloš, Muždalo, Anja, Lepšík, Martin, Černeková, Michaela, Radosavljević, Jelena, Fábry, Milan, Mitrová, Katarína, Chrudinová, Martina, Lin, Jingjing, Yurenko, Yevgen, Hobza, Pavel, Selicharová, Irena, Žáková, Lenka, Jiráček, Jiří

Source: In Journal of Biological Chemistry 15 November 2019 294(46):17371-17382

Pressure assisted partial filling affinity capillary electrophoresis employed for determination of binding constants of human insulin hexamer complexes with serotonin, dopamine, arginine, and phenol

Authors: Šolínová, Veronika, Žáková, Lenka, Jiráček, Jiří, Kašička, Václav

Source: In Analytica Chimica Acta 4 April 2019 1052:170-178

Radiolabeled hormones in insulin research, a minireview

Authors: Jiráček, Jiří, Žáková, Lenka, Marek, Aleš

Source: Journal of labelled compounds & radiopharmaceuticals. 63(14):576-581

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111881903.0x000001&indx=1&recIds=ETOCvdc_100111881903.0x000001

The final walk with preptin.

Authors: Mrázková, Lucie, Lubos, Marta, Voldřich, Jan, Kužmová, Erika, Zrubecká, Denisa, Gwozdiaková, Petra, Buděšínský, Miloš, Asai, Seiya, Marek, Aleš, Pícha, Jan, Tencerová, Michaela, Ferenčáková, Michaela, Barrera, Glenda Alquicer, Kaminský, Jakub, Jiráček, Jiří, Žáková, Lenka

Source: PLoS ONE; 9/12/2024, Vol. 19 Issue 9, p1-22, 22p

Subject Terms: INSULIN regulation, BIOLOGICAL systems, METABOLIC regulation, BONE metabolism, PEPTIDES

A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding

Authors: Chrudinová, Martina, Žáková, Lenka, Marek, Aleš, Socha, Ondřej, Buděšínský, Miloš, Hubálek, Martin, Pícha, Jan, Macháčková, Kateřina, Jiráček, Jiří, Selicharová, Irena

Source: In Journal of Biological Chemistry 26 October 2018 293(43):16818-16829

Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules

Alternate Title: Structural forms of storage insulin in pancreas (English)

Authors: Palivec, Vladimír, Viola, Cristina M., Kozak, Mateusz, Ganderton, Timothy R., Křížková, Květoslava, Turkenburg, Johan P., Haluŝková, Petra, Žáková, Lenka, Jiráĉek, Jiří, Jungwirth, Pavel, Brzozowski, Andrzej M.

Source: In Journal of Biological Chemistry May 2017 292(20):8342-8355

Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation

Authors: Macháčková, Kateřina, Chrudinová, Martina, Radosavljević, Jelena, Potalitsyn, Pavlo, Křížková, Květoslava, Fábry, Milan, Selicharová, Irena, Collinsová, Michaela, Brzozowski, Andrzej M., Žáková, Lenka

Source: Biochemistry. 57(16):2373-2382

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615819024&indx=1&recIds=ETOCRN615819024

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain

Authors: Hexnerová, Rozálie, Křížková, Květoslava, Fábry, Milan, Sieglová, Irena, Kedrová, Kateřina, Collinsová, Michaela, Ullrichová, Pavlína, Srb, Pavel, Williams, Christopher ^**, Crump, Matthew P. ^**, Tošner, Zdeněk, Jiráček, Jiří, Veverka, Václav, Žáková, Lenka

Source: In Journal of Biological Chemistry September 2016 291(40):21234-21245

A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin.

Authors: Asai, Seiya^1,2 (AUTHOR), Žáková, Lenka¹ (AUTHOR), Selicharová, Irena¹ (AUTHOR), Marek, Aleš¹ (AUTHOR), Jiráček, Jiří¹ (AUTHOR) jiracek@uochb.cas.cz

Source: Analytical & Bioanalytical Chemistry. Jul2021, Vol. 413 Issue 17, p4531-4543. 13p.

Subject Terms: *BINDING site assay, *RADIOLIGAND assay, *DOPAMINE receptors, *SEROTONIN receptors, *INSULIN, *ORNITHINE, *SEROTONIN

Chapter Six - Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2

Authors: Jiráček, Jiří ^*, Selicharová, Irena, Žáková, Lenka

Source: In Vitamins & Hormones 2023 123:187-230

Insulin—Insulin-like Growth Factors Hybrids as Molecular Probes of Hormone:Receptor Binding Specificity

Authors: Křížková, Květoslava, Chrudinová, Martina, Povalová, Anna, Selicharová, Irena, Collinsová, Michaela, Vaněk, Václav, Brzozowski, Andrzej M., Jiráček, Jiří, Žáková, Lenka

Source: Biochemistry. 55(21):2903-2913

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN606616398&indx=1&recIds=ETOCRN606616398

Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality

Authors: Žáková, Lenka, Kletvíková, Emília, Veverka, Václav, Lepšík, Martin, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.

Source: In Journal of Biological Chemistry 12 April 2013 288(15):10230-10240

New analogs of the CART peptide with anorexigenic potency: The importance of individual disulfide bridges

Authors: Blechová, Miroslava, Nagelová, Veronika, Žáková, Lenka, Demianová, Zuzana, Železná, Blanka, Maletínská, Lenka

Source: In Peptides January 2013 39:138-144

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2.

Authors: Potalitsyn, Pavlo, Mrázková, Lucie, Selicharová, Irena, Tencerová, Michaela, Ferenčáková, Michaela, Chrudinová, Martina, Turnovská, Tereza, Brzozowski, Andrzej Marek, Marek, Aleš, Kaminský, Jakub, Jiráček, Jiří, Žáková, Lenka

Source: Communications Biology; 8/19/2023, Vol. 6 Issue 1, p1-15, 15p

Subject Terms: INSULIN-like growth factor-binding proteins, CELL receptors, HUMAN growth, EMBRYOLOGY, CELL growth

Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues

Authors: Jiráček, Jiri, Žáková, Lenka, Antolíková, Emilia, Watson, Christopher J., Turkenburg, Johan P., Dodson, Guy G., Brzozowski, Andrzej M., Steiner, Donald F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Feb 01. 107(5), 1966-1970.

Access URL: https://www.jstor.org/stable/40536517

Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface

Authors: Antolíková, Emília, Žáková, Lenka, Turkenburg, Johan P., Watson, Christopher J., Hančlová, Ivona, Šanda, Miloslav, Cooper, Alan, Kraus, Tomáš, Brzozowski, A. Marek, Jiráček, Jiří

Source: In Journal of Biological Chemistry 21 October 2011 286(42):36968-36977