Hemodynamic Mechanisms Initiating Salt-Sensitive Hypertension in Rat Model of Primary Aldosteronism.

Authors: PRAVENEC, Michal, MLEJNEK, Petr, ŠIMÁKOVÁ, Miroslava, ŠILHAVÝ, Jan

Source: Physiological Research; 2024 Supplement, Vol. 73, pS365-S376, 12p

Subject Terms: HYPERTENSION, LABORATORY rats, HEMODYNAMICS, HUMAN physiology, BLOOD pressure, HYPERALDOSTERONISM, NEPHRECTOMY, VASCULAR resistance, ANIMAL models in research, CARDIAC output

Ketogenic diet can reduce pathologic presentation of TMEM70 deficiency in animal models

Authors: Mráček, Tomáš, Marković, Aleksandra, Mikesova, Jana, Pecina, Petr, Pecinová, Alena, Vrbacký, Marek, Tauchmannová, Kateřina, Shekhar, Nivasini, Šimáková, Miroslava, Kučera, Otto, Červinková, Zuzana, Pravenec, Michal, Houštěk, Josef

Source: Biochimica et biophysica acta. 1863(S)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168839898.0x000001&indx=1&recIds=ETOCvdc_100168839898.0x000001

Transgenic rescue approach ameliorates ATP synthase deficiency caused by the dysfunction of TMEM70 assembly factor in rat

Authors: Alán, Lukáš, Marković, Aleksandra, Tauchmannová, Kateřina, Šimáková, Miroslava, Mlejnek, Petr, Kaplanová, Vilma, Pecina, Petr, Pecinová, Alena, Šilhavý, Jan, Houštěk, Josef, Pravenec, Michal, Mráček, Tomáš

Source: Biochimica et biophysica acta. 1863(S)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168839880.0x000001&indx=1&recIds=ETOCvdc_100168839880.0x000001

Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat

Authors: Liška, František, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Strnad, Hynek, Trnovská, Jaroslava, Škop, Vojtěch, Kazdová, Ludmila, Starker, Colby G., Voytas, Daniel F., Izsvák, Zsuzsanna, Mancini, Massimiliano, Šeda, Ondřej, Křen, Vladimír, Pravenec, Michal

Source: Hypertension. 69(6):1084-1091

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100044175140.0x000001&indx=1&recIds=ETOCvdc_100044175140.0x000001

Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome

Authors: Pravenec, Michal, Kožich, Viktor, Krijt, Jakub, Sokolová, Jitka, Zídek, Václav, Landa, Vladimír, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Škop, Vojtěch, Trnovská, Jaroslava, Kazdová, Ludmila, Kajiya, Takashi, Wang, Jiaming, Kurtz, Theodore W.

Source: Hypertension. 67(2):335-341

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100036769982.0x000001&indx=1&recIds=ETOCvdc_100036769982.0x000001

Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat.

Authors: Šilhavý, Jan, Mlejnek, Petr, Šimáková, Miroslava, Liška, František, Malínská, Hana, Marková, Irena, Hüttl, Martina, Miklánková, Denisa, Mušálková, Dita, Stránecký, Viktor, Kmoch, Stanislav, Sticová, Eva, Vrbacký, Marek, Mráček, Tomáš, Pravenec, Michal

Source: Physiological Genomics; Dec2023, Vol. 55 Issue 12, p65-73, 9p

Subject Terms: NONSENSE mutation, LIPID metabolism, GLUCOSE metabolism, RATTUS norvegicus, PROTEOMICS, COAT proteins (Viruses), PROTEOLYSIS, INSULIN

CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study.

Authors: Silhavy, Jan, Mlejnek, Petr, Šimáková, Miroslava, Marková, Irena, Malínská, Hana, Hüttl, Martina, Kazdová, Ludmila, Kazantsev, Dmitry, Mancini, Massimiliano, Novotný, Jiří, Pravenec, Michal

Source: PLoS ONE; 4/13/2023, Vol. 18 Issue 4, p1-11, 11p

Subject Terms: BROWN adipose tissue, GLYCOGEN synthase kinase, LIPIDS, LABORATORY rats, HYPERTENSION, IN vitro studies

Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome.

Authors: Šilhavý, Jan, Mlejnek, Petr, Šimáková, Miroslava, Malínská, Hana, Marková, Irena, Hüttl, Martina, Miklánková, Denisa, Kazdová, Ludmila, Vrbacký, Marek, Pecinová, Alena, Mráček, Tomáš, Pravenec, Michal

Source: Metabolites (2218-1989); Feb2023, Vol. 13 Issue 2, p192, 16p

Subject Terms: PROTEOMICS, BEETS, METABOLIC models, METABOLIC syndrome, BLOOD lipids, C-reactive protein

Conplastic Strains for Identification of Retrograde Effects of Mitochondrial DNA Variation on Cardiometabolic Traits in the Spontaneously Hypertensive Rat.

Authors: PRAVENEC, Michal, ŠILHAVÝ, Jan, MLEJNEK, Petr, ŠIMÁKOVÁ, Miroslava, MRÁČEK, Tomáš, PECINOVÁ, Alena, TAUCHMANNOVÁ, Kateřina, HÜTL, Martina, MALÍNSKÁ, Hana, KAZDOVÁ, Ludmila, NECKÁŘ, Jan, KOLÁŘ, František, ŽURMANOVÁ, Jitka, NOVOTNÝ, Jiří, HOUŠTĚK, Josef

Source: Physiological Research; 2021 Supplement, Vol. 70, pS471-S481, 11p

Subject Terms: LIPID metabolism, CARDIOVASCULAR diseases risk factors, HYPERTENSION, BIOLOGICAL models, DNA, GENETIC polymorphisms, MITOCHONDRIA, RATS, HAPLOTYPES, PHENOTYPES

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Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls.

Authors: Trnovská, Jaroslava, Šilhavý, Jan, Kuda, Ondřej, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šimáková, Miroslava, Strnad, Hynek, Škop, Vojtěch, Oliyarnyk, Olena, Kazdová, Ludmila, Haluzík, Martin, Pravenec, Michal

Source: PLoS ONE; 6/6/2017, Vol. 12 Issue 6, p1-18, 18p

Subject Terms: INFLAMMATION prevention, C-reactive protein, HYPERTENSION, TUMOR necrosis factors, ADIPOSE tissues, LABORATORY rats

Downregulation of Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat.

Authors: Liška, František, Landa, Vladimír, Zídek, Václav, Mlejnek, Petr, Šilhavý, Jan, Šimáková, Miroslava, Strnad, Hynek, Trnovská, Jaroslava, Škop, Vojtěch, Kazdová,, Ludmila, Starker, Colby G., Voytas, Daniel F., Izsvák, Zsuzsanna, Mancini, Massimiliano, Šeda, Ondřej, Křen, Vladimír, Pravenec, Michal

Source: Hypertension (0194911X); Jun2017, Vol. 69 Issue 6, p1084-1091, 8p

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