Nucleus-targeted Silencer nanoplatform regulating ZEB1-AS1 in head and neck squamous cell carcinoma therapy

Authors: Haojie Yang, Yangfan Zhang, Zicong Tan, Zihao Liu, Yingzhe Yan, Qin Li, Phei Er Saw, Ning Liufu, Fengtao Ji

Source: Discover Nano, Vol 19, Iss 1, Pp 1-17 (2024)

Subject Terms: ZEB1-AS1, μ opioid receptor, Nanoparticles, ZEB1-AS1/ZEB1/MOR axis, Materials of engineering and construction. Mechanics of materials, TA401-492

File Description: electronic resource

Relation: https://doaj.org/toc/2731-9229

Access URL: https://doaj.org/article/7b983d163dee4c27ac9754dcd9e9b3af

Developing predictive models for µ opioid receptor binding using machine learning and deep learning techniques

Authors: Jie Liu, Jerry Li, Zoe Li, Fan Dong, Wenjing Guo, Weigong Ge, Tucker A. Patterson, Huixiao Hong

Source: Experimental Biology and Medicine, Vol 250 (2025)

Subject Terms: μ opioid receptor, binding activity, machine learning, deep learning, predictive model, Biology (General), QH301-705.5, Medicine

File Description: electronic resource

Relation: https://www.ebm-journal.org/articles/10.3389/ebm.2025.10359/full; https://doaj.org/toc/1535-3699

Access URL: https://doaj.org/article/964f33d7d87740fc922dfd281ea79248

CtBP1 is essential for epigenetic silencing of μ-opioid receptor genes in the dorsal root ganglion in spinal nerve ligation-induced neuropathic pain

Authors: Cheng-Yuan Lai, Ming-Chun Hsieh, Chou-Ming Yeh, Tzer-Bin Lin, Dylan Chou, Hsueh-Hsiao Wang, Kuan-Hung Lin, Jen-Kun Cheng, Po-Sheng Yang, Hsien-Yu Peng

Source: Neurotherapeutics, Vol 22, Iss 1, Pp e00493- (2025)

Subject Terms: Foxp1, CtBP1, HDAC2, μ-opioid receptor, DRG, Neuropathic pain, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1878747924001806; https://doaj.org/toc/1878-7479

Access URL: https://doaj.org/article/e3148b07bdc64560827d40ce01dcbbc0

Morphine promotes non-small cell lung cancer progression by downregulating E-cadherin via the PI3K/AKT/mTOR pathway

Authors: Fulei Gu, Yuxuan Zhou, Lili Tian, Jinyan Chen, Can Zhang, Zhangxiang Huang, Weifeng Yu, Kangjie Xie

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Subject Terms: Morphine, Non-small cell lung cancer, µ-Opioid receptor, Malignant biological behaviour, E-cadherin, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/459e86e9d8024314897e6cd9aae14976

Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report

Authors: Hayato Yokota, Yumiko Akamine, Mizuki Kobayashi, Takuro Kitabayashi, Misato Horie, Tentaro Endo, Takechiyo Yamada, Masafumi Kikuchi

Source: Journal of Pharmaceutical Health Care and Sciences, Vol 10, Iss 1, Pp 1-6 (2024)

Subject Terms: Constipation, Diverticulum, Intestinal perforation, Naldemedine, Peripherally acting μ-opioid receptor antagonists, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441

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Relation: https://doaj.org/toc/2055-0294

Access URL: https://doaj.org/article/67ae06cdfc84401493f0fa958bd84671

Advances in the structural understanding of opioid allostery

Authors: Ramos-Gonzalez, Nokomis ^{1, 2}, Varga, Balazs R. ^{1, 2}, Majumdar, Susruta ^{1, 2, ⁎}

Source: In Trends in Pharmacological Sciences February 2025 46(2):98-101

Efficacy and safety of SHR8554 on postoperative pain in subjects with moderate to severe acute pain following orthopedic surgery: A multicenter, randomized, double-blind, dose-explored, active-controlled, phase II/III clinical trial

Authors: Zhao, Yanhua ^{a, b, 1}, Lu, Zhisheng ^{a, b, 1}, Song, Xuesong ^c, Xie, Haihui ^d, Xiao, Xungang ^e, Wang, Guonian ^f, Zhou, Qi ^g, Zhang, Qingmei ^h, Liu, Liang ⁱ, Lan, Zhijian ^j, Bai, Ning ^k, Wang, Haiyan ^l, Pan, Zhihao ^m, Dong, Liang ⁿ, Lin, Xianzhong ^o, Chen, Gang ^p, Wang, Qinghui ^q, Dong, Jiangtao ^r, Deng, Jia ^s, Nan, Yongshan ^t, Zhang, Jiaqiang ^u, Zhou, Xiaohua ^v, Huang, Yanjuan ^w, Chen, Yongquan ^x, He, Huanzhong ^y, Yang, Ye ^z, Yao, Dengpan ^aa, Jia, Jintai ^ab, Jin, Shuan ^ac, Zhang, Yafeng ^ad, Luo, Zhonghui ^ae, Li, Jiangang ^af, Zhang, Linzhong ^ag, Wang, Fang ^ah, Jing, Juehua ^ai, Zhu, Jiang ^aj, Li, Lin ^ak, Wang, Guangda ^al, Guo, Huajing ^am, Wang, Qiang ^an, Su, Diansan ^{a, b, ao, ⁎}, Yu, Weifeng ^{a, b, ⁎⁎}, Gu, Xiyao ^{a, b, ⁎⁎}

Source: In Pharmacological Research February 2025 212

Positive allosteric modulation of µ-opioid receptor – A new possible approach in the pain management?

Authors: Król, Wojciech, Machelak, Weronika, Zielińska, Marta ^⁎

Source: In Biochemical Pharmacology February 2025 232

Signal profiles and spatial regulation of β-arrestin recruitment through Gβ5 and GRK3 at the μ-opioid receptor

Authors: Carino, Carlo Marion C. ^{a, 2}, Hiratsuka, Suzune ^{a, 2}, Kise, Ryoji ^{a, ⁎⁎}, Nakamura, Gaku ^a, Kawakami, Kouki ^{a, 1}, Yanagawa, Masataka ^{a, b}, Inoue, Asuka ^{a, c, ⁎}

Source: In European Journal of Pharmacology 15 January 2025 987

Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice

Authors: Marthe M. Vandeputte, Grant C. Glatfelter, Donna Walther, Nathan K. Layle, Danielle M. St. Germaine, István Ujváry, Donna M. Iula, Michael H. Baumann, Christophe P. Stove

Source: Pharmacological Research, Vol 210, Iss , Pp 107503- (2024)

Subject Terms: Nitazene, New synthetic opioids, In vitro and in vivo pharmacology, Structure-activity relationships, 2-Benzylbenzimidazoles, µ-Opioid receptor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824004481; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/1e6ec420012c427cb9ccc61ca32e7ede

Effects of Dual Inhibition at Dopamine Transporter and σ Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats

Authors: Hiranita, Takato ^*, Li, Su-Min, Katz, Jonathan L.

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2024 391(2):308-316

Regulation of Cannabinoid and Opioid Receptor Levels by Endogenous and Pharmacological Chaperones

Authors: Gupta, Achla, Gomes, Ivone, Osman, Aya, Fujita, Wakako ¹, Devi, Lakshmi A. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2024 391(2):279-288

Alternative Reinforcers Enhance the Effects of Opioid Antagonists, but Not Agonists, on Oxycodone Choice Self-Administration in Nonhuman Primates

Authors: de Moura, Fernando B., Kohut, Stephen J. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2024 391(2):301-307

Impact of Patient Subgroups on the Efficacy and Safety of Methylnaltrexone for Opioid-Induced Constipation in Patients with Advanced Illness

Authors: Mehta N, Slatkin NE, Israel RJ, Stambler N, Shah ED

Source: Journal of Pain Research, Vol Volume 16, Pp 3529-3543 (2023)

Subject Terms: methylnaltrexone, opioid-induced constipation, µ-opioid receptor antagonist, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.dovepress.com/impact-of-patient-subgroups-on-the-efficacy-and-safety-of-methylnaltre-peer-reviewed-fulltext-article-JPR; https://doaj.org/toc/1178-7090

Access URL: https://doaj.org/article/0b20ca3f21574ebf8de5d205ba0f2d6c

Reanalysis of a μ opioid receptor crystal structure reveals a covalent adduct with BU72

Authors: Thomas A. Munro

Source: BMC Biology, Vol 21, Iss 1, Pp 1-12 (2023)

Subject Terms: BU72, Covalent adduct, Crystal structure, μ opioid receptor, Revised stereochemistry, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/2b708a67afa04fe996a98a7fdb4b86dd

Analysis of Tianeptine in Dietary Supplements

Authors: Jared T. Seale, Emily A. Garden, John M. T. French, Owen M. McDougal

Source: Nutraceuticals, Vol 3, Iss 3, Pp 481-488 (2023)

Subject Terms: dietary supplement, μ-opioid-receptor agonist, addiction, antidepressant, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627

File Description: electronic resource

Relation: https://www.mdpi.com/1661-3821/3/3/34; https://doaj.org/toc/1661-3821

Access URL: https://doaj.org/article/d27b69e819964cca965c10792098239b

Editorial: Opioids and opioid receptors in pain, addiction, and mood disorders

Authors: Yu Qiu, Yu-Jun Wang

Source: Frontiers in Psychiatry, Vol 15 (2024)

Subject Terms: μ opioid receptor (MOR), addiction, obsessesive-compulsive disorder, oxycodone, tolerance, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1382894/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/f4c6f4acab4d41b99f18b9b345e94e19

Pharmacokinetics, metabolite profiling, safety and tolerability of YZJ-4729 tartrate, a novel G protein-biased μ-opioid receptor agonist, in healthy Chinese subjects

Authors: Yufeng Ni, Huaye Gao, Wen Ouyang, Guoping Yang, Minlu Cheng, Li Ding

Source: Frontiers in Pharmacology, Vol 14 (2024)

Subject Terms: YZJ-4729, acute pain, G protein-biased μ-opioid receptor agonist, pharmacokinetics, metabolite profiling, safety, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1295319/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/54fbacf444894073b12ecd6740c289d7

Identification and quantification of kukoamine A and kukoamine B as novel μ-opioid receptor agonists in potato and other solanaceous plants

Authors: Saller, Julia ^a, List, Carina ^a, Hübner, Harald ^b, Gmeiner, Peter ^{b, c}, Clark, Timothy ^d, Pischetsrieder, Monika ^{a, c, ⁎}

Source: In Food Chemistry 30 November 2023 427

Effects of a peripherally acting µ-opioid receptor antagonist for the prevention of recurrent acute pancreatitis: study protocol for an investigator-initiated, randomized, placebo-controlled, double-blind clinical trial (PAMORA-RAP trial)

Authors: Mathias E. Cook, Cecilie S. Knoph, Camilla A. Fjelsted, Jens B. Frøkjær, Anders E. Bilgrau, Srdan Novovic, Maiken Thyregod Jørgensen, Michael B. Mortensen, Liv B. J. Nielsen, Amer Hadi, Mark Berner-Hansen, Wiktor Rutkowski, Miroslav Vujasinovic, Matthias Löhr, Asbjørn M. Drewes, Søren S. Olesen

Source: Trials, Vol 24, Iss 1, Pp 1-13 (2023)

Subject Terms: Peripherally acting µ-opioid receptor antagonist, Recurrent acute pancreatitis, Randomized controlled trial, Naldemedine, Opioid, Magnetic resonance imaging, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1745-6215

Access URL: https://doaj.org/article/51ccbbb22fc14f1c96c466eef9a594fd